Dose-dependent reduction of myocardial infarct mass in rabbits by the nhe-1 inhibitor cariporide (hoe 642)

Clinical and Experimental Hypertension

Volumn 20, Issue 7, 1998, Pages 733-749

  Linz, W ^a   Albus, U ^a   Crause, P ^a   Jung, W ^a   Weichert, A ^a   Schoikens B A ^a   Scholz, W ^a  

^a SANOFI   (France)

Author keywords

Cariporide; HOE 642; Ischemia; Myocardial Infarction; NHE inhibition; Rabbits; Reperfusion

Indexed keywords

ANTIPORTER; ANTIPORTER INHIBITOR; CARDIOVASCULAR AGENT; CARIPORIDE; GUANIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DOSE RESPONSE; EXPERIMENTAL MODEL; FEMALE; HEART INFARCTION SIZE; HEART MUSCLE REPERFUSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RABBIT; TREATMENT OUTCOME;

EID: 0031686683     PISSN: 10641963     EISSN: None     Source Type: Journal    
DOI: 10.3109/10641969809052116     Document Type: Article

References (29)

1. Scholz W, Albus U, Counillon LT, Gögelein H, Lang H-J, Linz W, Weichert A, Schölkens BA: Protective effects of HOE 642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res 1995;29:260-268.
2. + exchanger: An update on structure, regulation and cardiac physiology. Biochem J 1993;296:273-285.
3. Karmazyn M: Ischemic and reperfusion injury in the heart. Cellular mechanisms and pharmacological interventions. Can J Physiol Pharmacol 1990;69:719-730.
4. + exchange inhibition in ischemic, reperfused porcine hearts. Circulation 1995;92:912-917.
5. + exchange. Am J Physiol 1993;265:H2017-H2026.
6. Murphy E, Perlman M, London RE, Steenbergen C: Amiloride delays the ischemia induced rise in cytosolic free calcium. Circ Res 1991;68:1250-1258.
7. Yano K, Maruyama T, Makino N, Matsui H, Yanaga T: Effects of amiloride on the mechanical, electrical and biochemical aspects of ischemia-reperfusion injury. Molec Cell Biochem 1993;121:75-83.
8. 2+ exchange. Circ Res 1992;71:547-557.
9. + antiporter inhibitor on postischemic reperfusion in pig heart. J Cardiovasc Pharmacol 1994;23:72-78.
10. + exchange inhibitors in cardiac ischemia. J Mol Cell Cardiol 1992;24:731-739.
11. + exchange inhibitor and its effects in cardiac ischemia. Br J Pharmacol 1993;109:562-568.
12. Coetzee WA, Opie LH: Effects of components of ischemia and metabolic inhibition on delayed afterdepolarizations in guinea pig papillary muscle. Circ Res 1987;61:157-165.
13. Steenbergen C, Murphy E, Watts JA, London RE: Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart. Circ Res 1990;66:135-146.
14. 2+], in energy deprivation contracture. Circ Res 1987;61:726-734.
15. 2+ overload in isolated perfused rabbit heart. Circulation 1994;89:2787-2798.
16. + exchange preserves viability, restores mechanical function, and prevents the pH paradox in reperfusion injury to rat neonatal myocytes. Basic Res Cardiol 1993;88:430-442.
17. + exchanger inhibitors against cardiac injury produced by ischemia/reperfusion, hypoxia/reoxygenation, and the calcium paradox. J Cardiovasc Pharmacol 1993;21:172-178.
18. Meng H-P, Maddaford TG, Pierce GN: Effect of amiloride and selected analogues on postischemic recovery of cardiac contractile function. Am J Physiol 1993;264:H1831-H1835.
19. Duan J, Karmazyn M: Protective effects of amiloride on the ischemic reperfused rat heart. Relation to mitochondrial function. Eur J Pharmacol 1992;210:149-157.
20. + exchange. Basic Res Cardiol 1996;91:203-209.
21. Hartman JG, Kurc GM, Hullinger TG, Wall TM: Inhibition of nitric oxide synthase prevents myocardial protection by ramiprilat. J Pharmacol Exp Ther 1994;270:1071-1078.
22. Birnbaum Y, Hale SL, Kloner RA: Differences in reperfusion length following 30 minutes of ischemia in the rabbit influence infarct size, as measured by triphenyltetrazolium chloride staining. J Mol Cell Cardiol 1997;29:657-666.
23. Schaper W, Gorge G, Winkler B, Schaper J: The collateral circulation of the heart. Prog Cardiovasc Dis 1988;31:57-77.
24. + exchange inhibitor, Hoe 642: Difference from preconditioning in the role of protein kinase C. J Am Coll Cardiol 1997;29:693-701.
25. +-exchange inhibition in regionally ischemic, reperfused porcine hearts. J Cardiovasc Res 1997;
26. + exchange. Cardiovasc Res 1997;35:80-89.
27. + exchange inhibitor reduces infarct size in pigs. Cardiovasc Res 1995;30:945-951.
28. +-ATPase activity in regionally ischemic rat hearts. Am J Physiol Heart Circ Physiol 1996;270:H957-H964.
29. + exchanger activity does not contribute to protection by ischemic preconditioning in the isolated rat heart. Circulation 1997;96:3617-3625.