Protection of the ischaemic myocardium by Na+/H+ exchange inhibitors: Potential mechanisms of action

Basic Research in Cardiology

Volumn 96, Issue 4, 2001, Pages 306-311

  Avkiran, M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 METHYL 5 METHYLSULFONYL 4 (1 PYRROLYL)BENZOYL]GUANIDINE; [4 [4 (2 FUROYL) 1 PIPERAZINYL] 3 (METHYLSULFONYL)BENZOYL]GUANIDINE; AMILORIDE; AMILORIDE DERIVATIVE; ANTIPORTER; ANTIPORTER INHIBITOR; CALCIUM ION; CARIPORIDE; ISOPROTEIN; PROTEIN INHIBITOR; PROTON; SL 591227; SODIUM ION; UNCLASSIFIED DRUG; ZONIPORIDE;

CALCIUM CELL LEVEL; CALCIUM METABOLISM; CALCIUM TRANSPORT; CATION TRANSPORT; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; MODULATION; NONHUMAN; PROTEIN SYNTHESIS REGULATION; PROTON SODIUM EXCHANGE; REGULATORY MECHANISM; REPERFUSION INJURY; REVIEW; SARCOLEMMA; SODIUM CELL LEVEL; SODIUM METABOLISM; SODIUM TRANSPORT;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CARDIOTONIC AGENTS; IONS; MYOCARDIAL ISCHEMIA; MYOCARDIUM; SARCOLEMMA; SODIUM; SODIUM-HYDROGEN ANTIPORTER;

EID: 0034919120     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950170037     Document Type: Review

References (48)

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3. + exchangers
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5. + exchange
6. + exchange inhibition-induced cardioprotection in dogs: Effects on neutrophils versus cardiomyocytes
7. + exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs
8. A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before or after coronary artery occlusion
9. 2 receptors
10. Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading
11. +-overload in ischemia and is cardioprotective
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15. + exchange
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18. + exchange inhibitor cariporide attenuates cell injury predominantly during ischemia and not at onset of reperfusion in porcine hearts with low residual flow
19. +exchanger
20. + exchange
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27. + exchanger
28. + exchange
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35. + exchanger inhibitors
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38. + exchange by oxidant stress requires stimulation of ERK but not p38 MAPK
39. + exchanger
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41. 2+ exchange
42. + exchanger are immediately active upon post-ischemic reperfusion in isolated rat hearts
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44. + exchangers
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46. + during myocardial ischemia
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