Regulation of cardiac sarcolemmal Na+/H+ exchanger activity: Potential pathophysiological significance of endogenous mediators and oxidant stress

Journal of Thrombosis and Thrombolysis

Volumn 8, Issue 1, 1999, Pages 25-32

  Avkiran, Metin ^a   Snabaitis, Andrew K ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Catecholamines; Endothelin; Ischemia; NHE; Oxidant stress; Reperfusion; Thrombin

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADRENERGIC RECEPTOR STIMULATING AGENT; CARIPORIDE; ENDOTHELIN; PROTON; SODIUM ION; THROMBIN;

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL MEMBRANE TRANSPORT; CELL PH; ENZYME ACTIVITY; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE INJURY; HEART MUSCLE REPERFUSION; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; REPERFUSION INJURY; REVIEW;

EID: 0032767849     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008938513337     Document Type: Review

References (84)

1. + exchangers of mammalian cells. J Biol Chem 1997;272:22373-22376.
2. + exchangers. Physiol Rev 1997;77:51-74.
3. Mahnensmith RL, Aronson PS. The plasma membrane sodium-hydrogen exchanger and its role in physiological and pathophysiological processes. Circ Res 1985;57:773-788.
4. Rosskopf D, Dusing R, Siffert W. Membrane sodium-proton exchange and primary hypertension. Hypertension 1993;21: 607-617.
5. Siffert W. Regulation of platelet function by sodium-hydrogen exchange. Cardiovasc Res 1995;29:1460-1466.
6. Lucchesi PA, Berk BC. Regulation of sodium-hydrogen exchange in vascular smooth muscle. Cardiovasc Res 1995;29: 172-177.
7. + antiporter (NHE-1) gene expression during growth, hypertrophy and proliferation of the rabbit cardiovascular system. J Mol Cell Cardiol 1995;27:729-742.
8. Schlüter K-D, Schäfer M, Balser C, Taimor G, Piper HM. Influence of pHi and creatine phosphate on α-adrenoceptor-mediated cardiac hypertrophy. J Mol Cell Cardiol 1998;30: 763-771.
9. Yamazaki T, Komuro I, Kudoh S, et al. Role of ion channels and exchangers in mechanical stretch-induced cardiomyocyte hypertrophy. Circ Res 1998;82:430-437.
10. Avkiran M. Myocardial Ischemia: Mechanisms, Reperfusion, Protection. Basel: Birkhauser, 1996:299-311.
11. Fröhlich O, Karmazyn M. The Na-H exchanger revisited: An update on Na-H exchange regulation and the role of the exchanger in hypertension and cardiac function in health and disease. Cardiovasc Res 1997;36:138-148.
12. + exchange inhibitor and its effects in cardiac ischemia. Br J Pharmacol 1993;109:562-568.
13. Scholz W, Albus U, Counillon L, et al. Protective effects of HOE 642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res 1995;29:260-268.
14. Scholz W, Albus U. Potential of selective sodium-hydrogen exchange inhibitors in cardiovascular therapy. Cardiovasc Res 1995;29:184-188.
15. Fliegel L, Dyck JRB. Molecular biology of the cardiac sodium/hydrogen exchanger. Cardiovasc Res 1995;29:155-159.
16. Lazdunski M, Frelin C, Vigne P. The sodium/hydrogen exchange system in cardiac cells: Its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol 1985;17:1029-1042.
17. + exchange in isolated myocytes from adult rat heart. Am J Physiol 1989;257: C207-C213.
18. Dennis SC, Gevers W, Opie LH. Protons in ischemia: Where do they come from; where do they go? J Mol Cell Cardiol 1991;23:1077-1086.
19. Meng HP, Pierce GN. Protective effects of 5-(N,N-dimethyl)amiloride on ischemia-reperfusion injury in hearts. Am J Physiol 1990;258:H1615-H1619.
20. + exchanger in reperfusion stunning in isolated perfused rat heart. J Cardiovasc Pharmacol 1993;22:877-883.
21. Meng HP, Maddaford TG, Pierce GN. Effect of amiloride and selected analogues on post-ischemic recovery of cardiac contractile function. Am J Physiol 1993;264:H1831-H1835.
22. + exchange immediately during reperfusion. Am J Physiol 1997;273:H2232-H2239.
23. + exchange. Am J Physiol 1988;255:H608-H615.
24. Moffat MP, Karmazyn M. Protective effect of the potent Na/H exchange inhibitor methylisobutyl amiloride against post-ischemic cotractile dysfunction in rat and guinea-pig hearts. J Mol Cell Cardiol 1993;25:959-971.
25. Myers ML, Mathur S, Li GH, Karmazyn M. Sodium-hydrogen exchange inhibitors improve postischaemic recovery of function in the perfused rabbit heart. Cardiovasc Res 1995; 29:209-214.
26. + exchange inhibition in ischemic, reperfused porcine hearts. Circulation 1995;92: 912-917.
27. + exchanger inhibitors. Am J Physiol 1996;270:H692-H700.
28. 2+ overload in isolated perfused rabbit heart. Circulation 1994;89:2787-2798.
29. + exchange inhibitor reduces infarct size in pigs. Cardiovasc Res 1995;30:945-951.
30. + exchange. Cardiovasc Res 1997;35: 80-89.
31. + exchanger inhibitor HOE-642 improves cardioplegic myocardial preservation under both normothermic and hypothermie conditions. Circulation 1997; 96:II266-II273.
32. Linz W, Albus U, Crause P, et al. Dose-dependent reduction of myocardial infarct mass in rabbits by the NHE-1 inhibitor cariporide (HOE 642). Clin Exp Hypertens 1998;20:733-749.
33. + exchange. Am J Physiol 1993;265:H2017-H2026.
34. Murphy E, Perlman M, London RE, Steenburgen C. Amiloride delays the ischemia-induced rise in cystosolic free calcium. Circ Res 1991;68:1250-1258.
35. Askenasy N, Viv A, Tassini M, Navon G. The relation between cellular sodium, pH and volumes and the activity of Na/H antiport during hypothermie ischemia: Multinuclear NMR studies of rat hearts. J Mol Cell Cardiol 1996;28:589-601.
36. + exchange in the sheep cardiac Purkinje fibre. J Physiol 1990;428:441-466.
37. + exchange inhibition protects against mechanical, ultrastructural, and biochemical impairment induced by low concentrations of lysophosphatidylcholine in isolated rat hearts. Circ Res 1997;80:95-102.
38. Schömig A, Richardt G. Cardiac sympathetic activity in myocardial ischemia: Release and effects of noradrenaline. Basic Res Cardiol 1990;85:9-30.
39. Corr PB, Yamada KA, DaTorre D. Modulation of α-adrenergic receptors and their intracellular coupling in the ischemic heart. Basic Res Cardiol 1990;85:31-45.
40. 1-adrenoceptor and purinoceptor agonists modulate Na-H antiport in single cells. Am J Physiol 1993;264:H310-H319.
41. 1-adrenoceptors. J Physiol 1993;464:49-73.
42. 1-adrenergic stimulation of Na-H exchange in cardiac myocytes. Am J Physiol 1992;263: C1096-C1102.
43. 1-adrenergic stimulation: A potential role for receptor-mediated activation of sarcolemmal sodium-hydrogen exchange. Cardiovasc Res 1995;29:222-230.
44. 1A-adrenoceptor subtype. Circ Res 1998;82:1078-1085.
45. 1-adrenergic receptor subtypes in human tissues: Implications for human α-adrenergic physiology. Mol Pharmacol 1994;45:171-175.
46. 1C. J Biol Chem 1996;271:5839-5843.
47. Guo H, Wasserstrom JA, Rosenthal JE. Effect of catecholamines on intracellular pH in sheep Purkinje fibres. J Physiol 1992;458:289-306.
48. + exchange in dog cardiac Purkinje fibres. J Physiol 1993;471:583-597.
49. + exchange in the sheep cardiac Purkinje fibre. J Physiol 1994;478:301-313.
50. Davies MJ, Woolf N, Robertson WB. Pathology of acute myocardial infarction with particular reference to occlusive coronary thrombi. Br Heart J 1976;38:659-664.
51. Wagner WR, Hubbell JA. Local thrombin synthesis and fibrinformation in an in vitro thromobosis model result in platelet recruitment and thrombin stabilization on collagen in heparinized blood. J Lab Clin Med 1990;116:636-650.
52. Coughlin SR. Thrombin receptor function and cardiovascular disease. Trends Cardiovasc Med 1994;4:77-83.
53. + exchanger. Evidence for a receptor-mediated mechanism involving protein kinase C. Circ Res 1996;79:705-715.
54. Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991;64:1057-1068.
55. Connolly AJ, Ishihara H, Kahn ML, Farese RV, Coughlin SR. Role of the thrombin receptor in development and evidence for a second receptor. Nature 1996;381:516-519.
56. Ishihara H, Connolly AJ, Zeng D, et al. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 1997;386:502-506.
57. Steinberg SF, Muske GA, Pak A, Zhang H. Cardiomyocytes express the proteinase-activated receptor-2 (PAR-2), which activates phosphoinositide hydrolysis, stimulates mitogen-activated protein kinase, enhances automaticity, and elevates intracellular calcium (abstr). Circulation 1997;96: I613.
58. Lerner DJ, Chen M, Tram T, Coughlin SR. Agonist recognition by proteinase-activated receptor 2 and thrombin receptor: Importance of extracellular loop interactions for receptor function. J Biol Chem 1996;271:13943-13947.
59. Tonnessen T, Naess PA, Kirkeboen KA, Offstad J, Ilebekk A, Christensen G. Endothelin is released from the porcine coronary circulation after short-term ischemia. J Cardiovasc Pharmacol 1993;22:S313-S316.
60. 125I-labeled endothelin-2 binding in rat cardiac membranes. Am J Physiol 1990;258:H829-H835.
61. + exchanger. Circ Res 1991;68:269-279.
62. + exchange is impaired in cardiac hypertrophy. J Clin Invest 1997;99:125-135.
63. Hoque ANE, Karmazyn M. Effect of sodium-hydrogen exchange inhibition on functional and metabolic impairment produced by oxidative stress in the isolated rat heart. Can J Phys Pharmacol 1997;75:326-334.
64. Myers ML, Farhangkhoee P, Karmazyn M. Hydrogen peroxide induced impairment of post-ischemic ventricular function is prevented by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). Cardiovasc Res 1998;40:209-296.
65. + exchange by hydrogen peroxide (abstr.) J Mol Cell Cardiol 1998;30:A339.
66. i recovery after global ischemia in the perfused heart. Circ Res 1993;72:993-1003.
67. 31P nuclear magnetic resonance studies of ischemia-induced fibrillation. Circ Res 1995;77:394-406.
68. Garlick PB, Davies MJ, Hearse DJ, Slater TF. Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy. Circ Res 1987;61:757-760.
69. Bolli R, Patel BS, Jeroudi MO, Lai EK, McCay PB. Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone. J Clin Invest 1988;82:476-485.
70. + exchange in neonatal rat cardiac myocytes. Circ Res 1998;82:1053-1062.
71. Lee JC, Laydon JT, McDonnel PC, et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994;372:739-746.
72. Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodget JR. Phosphorylation of c-Jun mediated by MAP kinases. Nature 1991;353:670-674.
73. Clerk A, Fuller SJ, Michael A, Sugden PH. Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses. J Biol Chem 1998;273:7228-7234.
74. + exchange and ERK1/2. Circ Res 1998;83:824-831.
75. + exchange in mediating effects of endothelin-1 on normal and ischemic/reperfused hearts. Circ Res 1994;75:369-378.
76. Brunner F, Opie LH. Role of endothelin A receptors in ischemic contracture and reperfusion injury. Circulation 1998;97:391-398.
77. 1-adrenergic mechanism. Circ Res 1993; 73:656-670.
78. Asimakis GK, Inners-McBride K, Medellin G, Conti VR. Ischemic preconditioning attenuates acidosis and postischemic dysfunction in isolated rat heart. Am J Physiol 1992; 263:H887-H894.
79. + extrusion in preconditioned rat hearts. Am J Physiol 1997; 273:H2257-H2262.
80. + exchanger activity does not contribute to protection by ischemic preconditioning in the isolated rat heart. Circulation 1997;96:3617-3625.
81. Goldstein JA, Butterfield MC, Ohnishi Y, Shelton TJ, Corr PB. Arrhythmogenic influence of intracoronary thrombosis during acute myocardial ischemia. Circulation 1994;90: 138-147.
82. Jacobsen AN, Du X-J, Lambert KA, Dart AM, Woodcock EA. Arrhythmogenic action of thrombin during myocardial reperfusion via release of inositol 1,4,5-triphosphate. Circulation 1996;93:23-26.
83. + exchanger contributes to the arrhythmogenic action of thrombin (abstr). Circulation 1997;96:I58.
84. + during myocardial ischemia. Am J Physiol 1995;268:H1740-H1748.