Cathepsin-B and cathepsin-L expression levels do not correlate with sensitivity of tumour cells to TNF-α-mediated apoptosis

British Journal of Cancer

Volumn 89, Issue 8, 2003, Pages 1574-1580

  Gewies, A ^a   Grimm, S ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Cathepsin; Cell death; Lysosomes; Overexpression

Indexed keywords

ALOXISTATIN; CA 074ME; CATHEPSIN B; CATHEPSIN L; CYSTEINE PROTEINASE INHIBITOR; DNA FRAGMENT; IMIDAZOLE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; FLUORESCENCE ACTIVATED CELL SORTING; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; LYSOSOME; PRIORITY JOURNAL; TUMOR CELL;

APOPTOSIS; CATHEPSIN B; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; HELA CELLS; HUMANS; LYSOSOMES; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0242574645     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601297     Document Type: Article

References (37)

1. Bauer MK, Schubert A, Rocks O, Grimm S (1999) Adenine nucleotide translocase-1, a component of the permeability transition pore, can dominantly induce apoptosis. J Cell Biol 147: 1493-1502
2. Buttle DJ, Murata M, Knight CG, Barrett AJ (1992) CA074 methyl ester: a proinhibitor for intracellular cathepsin B. Arch Biochem Biophys 299: 377-380
3. Chauhan SS, Goldstein LJ, Gottesman MM (1991) Expression of cathepsin L in human tumors. Cancer Res 51: 1478-1481
4. Deiss LP, Galinka H, Berissi H, Cohen O, Kimchi A (1996) Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. Embo J 15: 3861-3870
5. Dubowchik GM, Gawlak SL, Firestone RA (1995) The in vitro effects of three lysosomotropic detergents against three human tumor cell lines. Bioorganic Med Chem Lett 5: 893-898
6. Duffy MJ (1996) Proteases as prognostic markers in cancer. Clin Cancer Res 2: 613-618
7. Earnshaw WC, Martins LM, Kaufmann SH (1999) Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68: 383-424
8. Foghsgaard L, Wissing D, Mauch D, Lademann U, Bastholm L, Boes M, Elling F, Leist M, Jaattela M (2001) Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J Cell Biol 153: 999-1010
9. Gewies A, Grimm S (2003) UBP41 is a proapoptotic ubiquitin-specific protease. Cancer Res 63: 682-688
10. Gewies A, Rokhlin OW, Cohen MB (2000) Cytochrome c is involved in Fas-mediated apoptosis of prostatic carcinoma cell lines. Cancer Res 60: 2163-2168
11. Guicciardi ME, Deussing J, Miyoshi H, Bronk SF, Svingen PA, Peters C, Kaufmann SH, Gores GJ (2000) Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest 106: 1127-1137
12. Guicciardi ME, Miyoshi H, Bronk SF, Gores GJ (2001) Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications. Am J Pathol 159: 2045-2054
13. Kagedal K, Zhao M, Svensson I, Brunk UT (2001) Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem J 359: 335-343
14. Kamboj RC, Pal S, Raghav N, Singh H (1993) A selective colorimetric assay for cathepsin L using Z-Phe-Arg-4-methoxy-beta-naphthylamide. Biochimie 75: 873-878
15. Katz E, Deehan MR, Scatter S, Lord C, Sturrock RD, Harnett MM (2001) B cell receptor-stimulated mitochondrial phospholipase A2 activation and resultant disruption of mitochondrial membrane potential correlate with the induction of apoptosis in WEHI-231 B cells. J Immunol 166: 137-147
16. Kiso T, Usuki Y, Ping X, Fujita K, Taniguchi M (2001) L-2, 5-dihydrophenylalanine, an inducer of cathepsin-dependent apoptosis in human promyelocytic leukemia cells (HL-60). J Antibiot (Tokyo) 54: 810-817
17. Konduri S, Lakka SS, Tasiou A, Yanamandra N, Gondi CS, Dinh DH, Olivero WC, Gujrati M, Rao JS (2001) Elevated levels of cathepsin B in human glioblastoma cell lines. Int J Oncol 19: 519-524
18. Kos J, Lah TT (1998) Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review). Oncol Rep 5: 1349-1361
19. Lah TT, Kos J (1998) Cysteine proteinases in cancer progression and their clinical relevance for prognosis. Biol Chem 379: 125-130
20. Leist M, Jaattela M (2001) Triggering of apoptosis by cathepsins. Cell Death Differ 8: 324-326
21. Li W, Dalen H, Eaton JW, Yuan XM (2001) Apoptotic death of inflammatory cells in human atheroma. Arterioscler Thromb Vasc Biol 21: 1124-1130
22. Mathiasen IS, Hansen CM, Foghsgaard L, Jaattela M (2001) Sensitization to TNF-induced apoptosis by 1, 25-dihydroxy vitamin D(3) involves upregulation of the TNF receptor 1 and cathepsin B. Int J Cancer 93: 224-231
23. Montaser M, Lalmanach G, Mach L (2002) CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells. Biol Chem 383: 1305-1308
24. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63
25. Mund T, Gewies A, Schoenfeld N, Bauer MKA, Grimm S (2003) Spike, a novel BH3-only protein, regulates apoptosis at the endoplasmic reticulum. FASEB J 17: 696-698
26. Nagata S (1999) Fas ligand-induced apoptosis. Annu Rev Genet 33: 29-55
27. Neuzil J, Zhao M, Ostermann G, Sticha M, Gellert N, Weber C, Eaton JW, Brunk UT (2002) Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability. Biochem J 362: 709-715
28. Rasnick D (1985) Synthesis of peptide fluoromethyl ketones and the inhibition of human cathepsin B. Anal Biochem 149: 461-465
29. Roberts LR, Adjei PN, Gores GJ (1999) Cathepsins as effector proteases in hepatocyte apoptosis. Cell Biochem Biophys 30: 71-88
30. Robertson JD, Orrenius S (2000) Molecular mechanisms of apoptosis induced by cytotoxic chemicals. Crit Rev Toxicol 30: 609-627
31. Sivaparvathi M, Sawaya R, Wang SW, Rayford A, Yamamoto M, Liotta LA, Nicolson GL, Rao JS (1995) Overexpression and localization of cathepsin B during the progression of human gliomas. Clin Exp Metastasis 13: 49-56
32. Sloane BF (1990) Cathepsin B and cystatins: evidence for a role in cancer progression. Semin Cancer Biol 1: 137-152
33. Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC, Yin XM, Turk V, Salvesen GS (2001) Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem 276: 3149-3157
34. Turk B, Stoka V, Rozman-Pungercar J, Cirman T, Droga-Mazovec G, Oreic K, Turk V (2002) Apoptotic pathways: involvement of lysosomal proteases. Biol Chem 383: 1035-1044
35. Turk B, Turk D, Turk V (2000) Lysosomal cysteine proteases: more than scavengers. Biochim Biophys Acta 1477: 98-111
36. Varghese J, Radhika G, Sarin A (2001) The role of calpain in caspase activation during etoposide induced apoptosis in T cells. Eur J Immunol 31: 2035-2041
37. Yan S, Sameni M, Sloane BF (1998) Cathepsin B and human tumor progression. Biol Chem 379: 113-123