Cytochrome c is involved in Fas-mediated apoptosis of prostatic carcinoma cell lines

Cancer Research

Volumn 60, Issue 8, 2000, Pages 2163-2168

  Gewies, Andreas ^a   Rokhlin, Oskar W ^a   Cohen, Michael B ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 7; CASPASE 9; CYCLOHEXIMIDE; CYTOCHROME C OXIDASE; DNA FRAGMENT; FAS ANTIGEN; MONOCLONAL ANTIBODY;

APOPTOSIS; ARTICLE; CELL CULTURE; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIGATION; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD95; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASPASES; CELL NUCLEUS; CYCLOHEXIMIDE; CYTOCHROME C GROUP; CYTOPLASM; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMANS; MALE; MITOCHONDRIA; PROSTATIC NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0034655134     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Denmeade, S. R., McCloskey, D. E., Joseph, I. B., Hahm, H. A., Isaacs, J. T., and Davidson, N. E. Apoptosis in hormone-responsive malignancies. Adv. Pharmacol., 41: 553-583, 1997.
2. Amundson, S. A., Myers, T. G., and Fornace, A. J., Jr. Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Oncogene, 17: 3287-3299, 1998.
3. Brady, H. J., and Gil-Gomez, G. The cell cycle and apoptosis. Results Probl. Cell Differ., 23: 127-144, 1999.
4. Ashkenazi, A., and Dixit, V. M. Death receptors: signaling and modulation. Science (Washington DC), 281: 1305-1308, 1998.
5. Susin, S. A., Zamzami, N., and Kroemer, G. Mitochondria as regulators of apoptosis: doubt no more. Biochim. Biophys. Acta, 1366: 151-165, 1998.
6. Green, D. R., and Reed, J. C. Mitochondria and apoptosis. Science (Washington DC), 281: 1309-1312, 1998.
7. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., and Wang, X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell, 91: 479-489, 1997.
8. Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., and Alnemri, E. S. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol. Cell, 1: 949-957, 1998.
9. Pan, G., Humke, E. W., and Dixit, V. M. Activation of caspases triggered by cytochrome c in vitro [published erratum appears in FEBS Lett., 428: 309, 1998]. FEBS Lett., 426: 151-154, 1998.
10. Cryns, V., and Yuan, J. Proteases to die for [published erratum appears in Genes Dev., 13: 371, 1999]. Genes Dev., 12: 1551-1570, 1998.
11. Yang, J., Liu, X., Bhalla, K., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T. I., Jones, D. P., and Wang, X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked [see comments]. Science (Washington DC), 275: 1129-1132, 1997.
12. Medema, J. P., Scaffidi, C., Krammer, P. H., and Peter, M. E. Bcl-xL acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex. J. Biol. Chem., 273: 3388-3393, 1998.
13. Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., Larochette, N., Goodlett, D. R., Aebersold, R., Siderovski, D. P., Penninger, J. M., and Kroemer, G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature (Lond.), 397: 441-446, 1999.
14. Nagata, S., and Golstein, P. The Fas death factor. Science (Washington DC), 267: 1449-1456, 1995.
15. Trauth, B. C., Klas, C., Peters, A. M., Matzku, S., Moller, P., Falk, W., Debatin, K. M., and Krammer, P. H. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science (Washington DC), 245: 301-305, 1989.
16. Yonehara, S., Ishii, A., and Yonehara, M. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-down-regulated with the receptor of tumor necrosis factor. J. Exp. Med., 169: 1747-1756, 1989.
17. Nagata, S. Apoptosis by death factor. Cell, 88: 355-365, 1997.
18. Medema, J. P., Scaffidi, C., Kischkel, F. C., Shevchenko, A., Mann, M., Krammer, P. H., and Peter, M. E. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J., 16: 2794-2804, 1997.
19. Muzio, M., Salvesen, G. S., and Dixit, V. M. FLlCE induced apoptosis in a cell-free system: cleavage of caspase zymogens. J. Biol. Chem., 272: 2952-2956, 1997.
20. Li, H., Zhu, H., Xu, C. J., and Yuan, J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell, 94: 491-501, 1998.
21. Rodriguez, I., Matsuura, K., Khatib, K., Reed, J. C., Nagata, S., and Vassalli, P. A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection. J. Exp. Med., 183: 1031-1036, 1996.
22. Memon, S. A., Moreno, M. B., Petrak, D., and Zacharchuk, C. M. Bcl-2 blocks glucocorticoid-but not Fas-or activation-induced apoptosis in a T cell hybridoma. J. Immunol., 155: 4644-4652, 1995.
23. Chiu, V. K., Walsh, C. M., Liu, C. C., Reed, J. C., and Clark, W. R. Bcl-2 blocks degranulation but not Fas-based cell-mediated cytotoxicity. J. Immunol., 154: 2023-2032, 1995.
24. Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K. M., Krammer, P. H., and Peter, M. E. Two CD95 (APO-1/Fas) signaling pathways. EMBO J., 17: 1675-1687, 1998.
25. Li, F., Srinivasan, A., Wang, Y., Armstrong, R. C., Tomaselli, K. J., and Fritz, L. C. Cell-specific induction of apoptosis by microinjection of cytochrome c: Bcl-xL has activity independent of cytochrome c release. J. Biol. Chem., 272: 30299-30305, 1997.
26. Srinivasan, A., Li, F., Wong, A., Kodandapani, L., Smidt, R., Jr., Krebs, J. F., Fritz, L. C., Wu, J. C., and Tomaselli, K. J. Bcl-xL functions downstream of caspase-8 to inhibit Fas-and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells. J. Biol. Chem., 273: 4523-4529, 1998.
27. Armstrong, R. C., Aja, T., Xiang, J., Gaur, S., Krebs, J. F., Hoang, K., Bai, X., Korsmeyer, S. J., Karanewsky, D. S., Fritz, L. C., and Tomaselli, K. J. Fas-induced activation of the cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors. J. Biol. Chem., 271: 16850-16855, 1996.
28. Kuwana, T., Smith, J. J., Muzio, M., Dixit, V., Newmeyer, D. D., and Kornbluth, S. Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. J. Biol. Chem., 273: 16589-16594, 1998.
29. Bossy-Wetzel, E., and Green, D. R. Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. J. Biol. Chem., 274: 17484-17490, 1999.
30. Rokhlin, O. W., Bishop, G. A., Hostager, B. S., Waldschmidt, T. J., Sidorenko, S. P., Pavloff, N., Kiefer, M. C., Umansky, S. R., Glover, R. A., and Cohen, M. B. Fas-mediated apoptosis in human prostatic carcinoma cell lines. Cancer Res., 57: 1758-1768, 1997.
31. Rokhlin, O. W., Glover, R. A., and Cohen, M. B. Fas-mediated apoptosis in human prostatic carcinoma cell lines occurs via activation of caspase-8 and caspase-7. Cancer Res., 58: 5870-5875, 1998.
32. Rokhlin, O. W., Hostager, B. S., Bishop, G. A., Sidorenko, S. P., Glover, R. A., Gudkov, A. V., and Cohen, M. B. Dominant nature of the resistance to Fas-and tumor necrosis factor-α-mediated apoptosis in human prostatic carcinoma cell lines. Cancer Res., 57: 3941-3943, 1997.
33. Fearnhead, H. O., McCurrach, M. E., O'Neill, J., Zhang, K., Lowe, S. W., and Lazebnik, Y. A. Oncogene-dependent apoptosis in extracts from drug-resistant cells. Genes Dev., 11: 1266-1276, 1997.
34. Wood, E. R., and Earnshaw, W. C. Mitotic chromatin condensation in vitro using somatic cell extracts and nuclei with variable levels of endogenous topoisomerase II. J. Cell Biol., 111: 2839-2850, 1990.
35. Zou, H., Henzel, W. J., Liu, X., Lutschg, A., and Wang, X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell, 90: 405-413, 1997.
36. Luo, X., Budihardjo, I., Zou, H., Slaughter, C., and Wang, X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell, 94: 481-490, 1998.
37. Hirata, H., Takahashi, A., Kobayashi, S., Yonehara, S., Sawai, H., Okazaki, T., Yamamoto, K., and Sasada, M. Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis J. Exp. Med., 187: 587-600, 1998.
38. Sun, X. M., MacFarlane, M., Zhuang, J., Wolf, B. B., Green, D. R., and Cohen, G. M. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J. Biol. Chem., 274: 5053-5060, 1999.
39. Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K. M., Krammer, P. H., and Peter, M. E. Two CD95 (APO-1/Fas) signaling pathways. EMBO J., 17: 1675-1687, 1998.
40. Chauhan, D., Pandey, P., Ogata, A., Teoh, G., Krett, N., Halgren, R., Rosen, S., Kufe, D., Kharbanda, S., and Anderson, K. Cytochrome c-dependent and -independent induction of apoptosis in multiple myeloma cells. J. Biol. Chem., 272: 29995-29997, 1997.
41. Adachi, S., Gottlieb, R. A., and Babior, B. M. Lack of release of cytochrome c from mitochondria into cytosol early in the course of Fas-mediated apoptosis of Jurkat cells. J. Biol. Chem., 273: 19892-19894, 1998.
42. Adachi, S., Cross, A. R., Babior, B. M., and Gottlieb, R. A. Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis. J. Biol. Chem., 272: 21878-21882, 1997.
43. Marcelli, M., Cunningham, G. R., Walkup, M., He, Z., Sturgis, L., Kagan, C., Mannucci, R., Nicoletti, I., Teng, B., and Denner, L. Signaling pathway activated during apoptosis of the prostate cancer cell line LNCaP: overexpression of caspase-7 as a new gene therapy strategy for prostate cancer. Cancer Res., 59: 382-390, 1999.
44. Carson, J. P., Kulik, G., and Weber, M. J. Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3′-kinase and Akt/protein kinase B. Cancer Res., 59: 1449-1453, 1999.
45. Tang, D. G., Li, L., Zhu, Z., and Joshi, B. Apoptosis in the absence of cytochrome c accumulation in the cytosol. Biochem. Biophys. Res. Commun., 242: 380-384, 1998.
46. Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., and Nagata, S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature (Lond.), 391: 43-50, 1998.
47. Lazebnik, Y. A., Cole, S., Cooke, C. A., Nelson, W. G., and Earnshaw, W. C. Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis. J. Cell Biol., 123: 7-22, 1993.
48. Liu, X., Kim, C. N., Yang, J., Jemmerson, R., and Wang, X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell, 86: 147-157, 1996.
49. Mesner, P. W., Bible, K. C., Martins, L. M., Kottke, T. J., Srinivasula, S. M., Svingen, P. A., Chilcote, T. J., Basi, G. S., Tung, J. S., Krajewski, S., Reed, J. C., Alnemri, E. S., Earnshaw, W. C., and Kaufmann, S. H. Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions. J. Biol. Chem., 274: 22635-22645, 1999.