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Volumn 26, Issue 3, 2003, Pages 183-191

Antisense DNAs as targeted genetic medicine to treat cancer

Author keywords

Antisense; Cancer; Chemotherapy; Gene expression; Growth inhibition; Oligonucleotides

Indexed keywords

COMPLEMENTARY DNA;

EID: 0142172151     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02976827     Document Type: Review
Times cited : (8)

References (87)
  • 1
    • 0030271959 scopus 로고    scopus 로고
    • Antisense oligonucleotides: Towards clinical trials
    • Agrawal, S., Antisense oligonucleotides: towards clinical trials. Trends Biotechnol., 14, 376-387 (1996a).
    • (1996) Trends Biotechnol. , vol.14 , pp. 376-387
    • Agrawal, S.1
  • 4
    • 0031948835 scopus 로고    scopus 로고
    • Mixed backbone oligonucleotdes: Improvement in oligonucleotide-induced toxicity in vivo
    • Agrawal, S. and Zhao, Q., Mixed backbone oligonucleotdes: improvement in oligonucleotide-induced toxicity in vivo. Antisense & Nucleic Acid Drug Dev., 8, 135-139 (1998a).
    • (1998) Antisense & Nucleic Acid Drug Dev. , vol.8 , pp. 135-139
    • Agrawal, S.1    Zhao, Q.2
  • 6
    • 0031027349 scopus 로고    scopus 로고
    • In vivo studies with antisense oligonucleotides
    • Akhtar, S. and Agrawal, S., In vivo studies with antisense oligonucleotides. Trends Pharmacol Sci., 18, 12-18 (1997).
    • (1997) Trends Pharmacol Sci. , vol.18 , pp. 12-18
    • Akhtar, S.1    Agrawal, S.2
  • 8
    • 0033517254 scopus 로고    scopus 로고
    • Protein kinase A RIa subunit-directed antisense inhibition of ovarian cancer cell growth: Crosstalk with tyrosine kinase signaling pathway
    • Alper, O., Hacker, N. F., and Cho-Chung, Y. S., Protein kinase A RIa subunit-directed antisense inhibition of ovarian cancer cell growth: crosstalk with tyrosine kinase signaling pathway. Oncogene, 18, 4999-5004 (1999).
    • (1999) Oncogene , vol.18 , pp. 4999-5004
    • Alper, O.1    Hacker, N.F.2    Cho-Chung, Y.S.3
  • 10
    • 0031912506 scopus 로고    scopus 로고
    • Antisense oligonucleotides: Is the glass half full or half empty?
    • Bennett, C. F., Antisense oligonucleotides: is the glass half full or half empty? Biochem. Pharmacol., 55, 9-19 (1998).
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 9-19
    • Bennett, C.F.1
  • 11
    • 0028074919 scopus 로고
    • Growth-regulatory effect of gastrin on human colon cancer cell lines is determined by protein kinase a isoform content
    • Bold, R. J., Alpard, S., Ishizuka, J., Townsend, Jr. C. M., and Thompson, J. C., Growth-regulatory effect of gastrin on human colon cancer cell lines is determined by protein kinase a isoform content. Regul. Pept., 53, 61-70 (1994).
    • (1994) Regul. Pept. , vol.53 , pp. 61-70
    • Bold, R.J.1    Alpard, S.2    Ishizuka, J.3    Townsend Jr., C.M.4    Thompson, J.C.5
  • 12
    • 0028218440 scopus 로고
    • Protein kinase A (PK-A) regulatory subunit epxression in colorectal cancer and related mucosa
    • Bradbury, A. W., Carter, D. C., Miller, W. R., Cho-Chung, Y. S., and Clair, T., Protein kinase A (PK-A) regulatory subunit epxression in colorectal cancer and related mucosa. Br. J. Cancer, 69, 738-742 (1994).
    • (1994) Br. J. Cancer , vol.69 , pp. 738-742
    • Bradbury, A.W.1    Carter, D.C.2    Miller, W.R.3    Cho-Chung, Y.S.4    Clair, T.5
  • 13
    • 0033178247 scopus 로고    scopus 로고
    • Novel anticancer drug discovery
    • Buolamwini, J. K., Novel anticancer drug discovery. Curr. Opin. Chem. Biol., 3, 500-509 (1999).
    • (1999) Curr. Opin. Chem. Biol. , vol.3 , pp. 500-509
    • Buolamwini, J.K.1
  • 15
    • 20244380289 scopus 로고    scopus 로고
    • A safety and pharmacokinetic study of a mixedbackbone oligonucleotide (GEM 231) targeting the type I protein kinase A by 2-hour infusions in patients with refractory solid tumors
    • Chen, H. X., Marshall, J. L., Ness, E., Martin, R. R., Dvorchik, B., Rizvi, N., Marquis, I., McKinlay, M., Dahut, W., and Hawkins, M. J., A safety and pharmacokinetic study of a mixedbackbone oligonucleotide (GEM 231) targeting the type I protein kinase A by 2-hour infusions in patients with refractory solid tumors. Clin. Cancer. Res., 6, 1259-1266 (2000).
    • (2000) Clin. Cancer. Res. , vol.6 , pp. 1259-1266
    • Chen, H.X.1    Marshall, J.L.2    Ness, E.3    Martin, R.R.4    Dvorchik, B.5    Rizvi, N.6    Marquis, I.7    McKinlay, M.8    Dahut, W.9    Hawkins, M.J.10
  • 16
    • 0031939875 scopus 로고    scopus 로고
    • Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
    • Chen, L., Agrawal, S., Zhou, W., Zhang, R., and Chen, J., Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage. Proc. Natl. Acad. Sci. USA, 95, 195-200 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 195-200
    • Chen, L.1    Agrawal, S.2    Zhou, W.3    Zhang, R.4    Chen, J.5
  • 17
    • 0035678781 scopus 로고    scopus 로고
    • A phase I dose-finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer
    • Chi, K. N., Gleave, M. E., Klasa, R., Murray, N., Bryce, C., Lopes de Menezes, D. E., D'Aloisio, S., and Tolcher, A. W., A phase I dose-finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer. Clin. Cancer. Res., 7, 3920-3927 (2001).
    • (2001) Clin. Cancer. Res. , vol.7 , pp. 3920-3927
    • Chi, K.N.1    Gleave, M.E.2    Klasa, R.3    Murray, N.4    Bryce, C.5    Lopes De Menezes, D.E.6    D'Aloisio, S.7    Tolcher, A.W.8
  • 19
    • 0036188072 scopus 로고    scopus 로고
    • Protein kinase A RIa antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad- hypophosphorylation
    • Cho, Y. S., Kim, M. K., Tan, L., Srivastava, R., Agrawal, S., and Cho-Chung, Y. S., Protein kinase A RIa antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad- hypophosphorylation. Clin. Cancer. Res., 8, 607-614 (2002).
    • (2002) Clin. Cancer. Res. , vol.8 , pp. 607-614
    • Cho, Y.S.1    Kim, M.K.2    Tan, L.3    Srivastava, R.4    Agrawal, S.5    Cho-Chung, Y.S.6
  • 20
    • 0033753982 scopus 로고    scopus 로고
    • Antisense and therapeutic oligonucleotides: Toward a gene-targeting cancer clinic
    • Cho-Chung, Y. S., Antisense and therapeutic oligonucleotides: toward a gene-targeting cancer clinic. Exp. Opin. Ther. Patent., 10, 1711-1724 (2000).
    • (2000) Exp. Opin. Ther. Patent. , vol.10 , pp. 1711-1724
    • Cho-Chung, Y.S.1
  • 21
    • 0036628388 scopus 로고    scopus 로고
    • Antisense DNAs as targeted therapeutics for cancer: No longer a dream
    • Cho-Chung, Y. S., Antisense DNAs as targeted therapeutics for cancer: No longer a dream. Curr. Opin. Invest. Drugs, 3, 934-939 (2002).
    • (2002) Curr. Opin. Invest. Drugs , vol.3 , pp. 934-939
    • Cho-Chung, Y.S.1
  • 23
    • 0025775108 scopus 로고
    • Role of site-selective cAMP analogs in the control and reversal of malignancy
    • Cho-Chung, Y. S., Clair, T., Tortora, G., and Yokozaki, H., Role of site-selective cAMP analogs in the control and reversal of malignancy. Pharmac. Ther., 50, 1-33 (1991).
    • (1991) Pharmac. Ther. , vol.50 , pp. 1-33
    • Cho-Chung, Y.S.1    Clair, T.2    Tortora, G.3    Yokozaki, H.4
  • 25
    • 0027499522 scopus 로고
    • Down-regulation of RIα subunit of cAMP-dependent protein kinase induces growth inhibition of human mammary epithelial cells transformed by c-Ha-ras and c-erbB-2 proto-oncogenes
    • Ciardiello, F., Pepe, S., Bianco, C., Baldassarre, G., Ruggiero, A., Selvam, M. P., Bianco, A. R., and Tortora, G., Down-regulation of RIα subunit of cAMP-dependent protein kinase induces growth inhibition of human mammary epithelial cells transformed by c-Ha-ras and c-erbB-2 proto-oncogenes. Int. J. Cancer, 53, 438-443 (1993).
    • (1993) Int. J. Cancer , vol.53 , pp. 438-443
    • Ciardiello, F.1    Pepe, S.2    Bianco, C.3    Baldassarre, G.4    Ruggiero, A.5    Selvam, M.P.6    Bianco, A.R.7    Tortora, G.8
  • 26
    • 0031963158 scopus 로고    scopus 로고
    • c-myc antisense oligodeoxynucleotides enhance the efficacy of cisplatin in melanoma chemotherapy in vitro and in nude mice
    • Citro, G., D'Agnano, I., Leonetti, C., Perini, R., Bucci, B., Zon, G., Calabretta, B., and Zupi, G., c-myc antisense oligodeoxynucleotides enhance the efficacy of cisplatin in melanoma chemotherapy in vitro and in nude mice. Cancer Res., 58, 283-289 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 283-289
    • Citro, G.1    D'Agnano, I.2    Leonetti, C.3    Perini, R.4    Bucci, B.5    Zon, G.6    Calabretta, B.7    Zupi, G.8
  • 27
    • 0030838791 scopus 로고    scopus 로고
    • In vitro and in vivo activity of antisense inhibitors of ras: Potential for clinical development
    • Cowsert, L. M., In vitro and in vivo activity of antisense inhibitors of ras: potential for clinical development. Anticancer Drug Des., 12, 359-371 (1997).
    • (1997) Anticancer Drug Des. , vol.12 , pp. 359-371
    • Cowsert, L.M.1
  • 29
    • 0000532453 scopus 로고    scopus 로고
    • Antisense Oligonucleotides in the Treatment of Cancer
    • Dorr, F., Antisense Oligonucleotides in the Treatment of Cancer. Antisense Nucleic. Acid. Drug Dev., 9, 391-396 (1999).
    • (1999) Antisense Nucleic. Acid. Drug Dev. , vol.9 , pp. 391-396
    • Dorr, F.1
  • 30
    • 0036168035 scopus 로고    scopus 로고
    • Antisense and sensibility
    • Dove, A., Antisense and sensibility. Nat. Biotechnol., 20, 121-124 (2002).
    • (2002) Nat. Biotechnol. , vol.20 , pp. 121-124
    • Dove, A.1
  • 31
    • 0029164957 scopus 로고
    • Inhibition of high affinity basic fibroblast growth factor binding by oligonucleotides
    • Fennewald, S. M. and Rando, R. F., Inhibition of high affinity basic fibroblast growth factor binding by oligonucleotides. J. Biol. Chem., 270, 21718-21721 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 21718-21721
    • Fennewald, S.M.1    Rando, R.F.2
  • 32
    • 0031963427 scopus 로고    scopus 로고
    • Antitumor activity of a PKC-α antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice
    • Geiger, T., Muller, M., Dean, N.M., and Fabbro, D., Antitumor activity of a PKC-α antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice. Anticancer Drug Des., 13, 35-45 (1998).
    • (1998) Anticancer Drug Des. , vol.13 , pp. 35-45
    • Geiger, T.1    Muller, M.2    Dean, N.M.3    Fabbro, D.4
  • 33
    • 0031935087 scopus 로고    scopus 로고
    • Antisense oligonucleotide therapeutics for human leukemia
    • Gewirtz, A. M., Antisense oligonucleotide therapeutics for human leukemia. Curr. Opin. Hematol., 5, 59-71 (1998).
    • (1998) Curr. Opin. Hematol. , vol.5 , pp. 59-71
    • Gewirtz, A.M.1
  • 34
    • 0034015778 scopus 로고    scopus 로고
    • Oligonucleotide therapeutics: A step forward
    • Gewirtz, A. M., Oligonucleotide therapeutics: a step forward. J. Clin. Oncol., 18, 1809-1811 (2000).
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1809-1811
    • Gewirtz, A.M.1
  • 35
    • 0000939974 scopus 로고    scopus 로고
    • Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue
    • Gordge, P. C., Hulme, M. J., Clegg, R. A., and Miller, W. R., Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue. Eur. J. Cancer, 32A, 2120-2126 (1996).
    • (1996) Eur. J. Cancer , vol.32 A , pp. 2120-2126
    • Gordge, P.C.1    Hulme, M.J.2    Clegg, R.A.3    Miller, W.R.4
  • 36
    • 0028815149 scopus 로고
    • Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix
    • Guvakova, M. A., Yakubov, L. A., Vlodavsky, I., Tonkinson, J. L., and Stein, C. A., Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix. J. Biol. Chem., 270, 2620-2627 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 2620-2627
    • Guvakova, M.A.1    Yakubov, L.A.2    Vlodavsky, I.3    Tonkinson, J.L.4    Stein, C.A.5
  • 37
    • 0018575462 scopus 로고
    • Altered cellular ratio of type I and type II cyclic AMP-dependent protein kinase in human mammary tumors
    • Handschin, J. S. and Eppenberger, U., Altered cellular ratio of type I and type II cyclic AMP-dependent protein kinase in human mammary tumors. FEBS Lett., 106, 301-304 (1979).
    • (1979) FEBS Lett. , vol.106 , pp. 301-304
    • Handschin, J.S.1    Eppenberger, U.2
  • 39
    • 0029047009 scopus 로고
    • Interleukin-12. Biologic activity, therapeutic utility, and role in disease
    • Hendrzak, J. A. and Brunda, M. J., Interleukin-12. Biologic activity, therapeutic utility, and role in disease. Lab. Invest., 72, 619-637 (1995).
    • (1995) Lab. Invest. , vol.72 , pp. 619-637
    • Hendrzak, J.A.1    Brunda, M.J.2
  • 42
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
    • Klinman, D. M., Yi, A. K., Beaucage, S. L., Conover, J., and Krieg, A. M., CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc. Natl. Acad. Sci. USA, 93, 2879-2883 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.K.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 44
    • 0001343192 scopus 로고    scopus 로고
    • Leukocyte stimulation by oligodeoxynucleotides
    • C. A. Stein and A. M. Krieg, Eds. New York, Wiley-Liss
    • Krieg, A. M., Leukocyte stimulation by oligodeoxynucleotides, In C. A. Stein and A. M. Krieg, Eds. Applied Antisense Oligonucleotide Technology. New York, Wiley-Liss, pp. 431-448 (1998).
    • (1998) Applied Antisense Oligonucleotide Technology , pp. 431-448
    • Krieg, A.M.1
  • 47
    • 0032587480 scopus 로고    scopus 로고
    • Increased expression of the RIα subunit of the cAMP-dependent protein kinase A is associated with advanced stage of ovarian cancer
    • McDaid, H. M., Cairns, M. T., Atkinson, R. I., McAleer, S., Harkin, D. P., Gilmore, P., and Johnston, P. G., Increased expression of the RIα subunit of the cAMP-dependent protein kinase A is associated with advanced stage of ovarian cancer. Br. J. Cancer., 79, 933-939 (1999).
    • (1999) Br. J. Cancer. , vol.79 , pp. 933-939
    • McDaid, H.M.1    Cairns, M.T.2    Atkinson, R.I.3    McAleer, S.4    Harkin, D.P.5    Gilmore, P.6    Johnston, P.G.7
  • 48
    • 0028598284 scopus 로고
    • Study of antisense oligonucleotide phosphorothioates containing segments of oligodeoxynucleotides and 2′-O-methyloligoribonucleotides
    • Metelev, V., Liszlewicz, J., and Agrawal, S., Study of antisense oligonucleotide phosphorothioates containing segments of oligodeoxynucleotides and 2′-O-methyloligoribonucleotides. Bioorg. Medicinal Chem. Lett., 4, 2929-2934 (1994).
    • (1994) Bioorg. Medicinal Chem. Lett. , vol.4 , pp. 2929-2934
    • Metelev, V.1    Liszlewicz, J.2    Agrawal, S.3
  • 49
    • 0027195001 scopus 로고
    • Types of cyclic AMP binding proteins in human breast cancers
    • Miller, W. R., Hulme, M. J., Cho-Chung, Y. S., and Elton, R. A., Types of cyclic AMP binding proteins in human breast cancers. Eur. J. Cancer, 29A, 989-991 (1993a).
    • (1993) Eur. J. Cancer , vol.29 A , pp. 989-991
    • Miller, W.R.1    Hulme, M.J.2    Cho-Chung, Y.S.3    Elton, R.A.4
  • 50
    • 0027220462 scopus 로고
    • Tumor cyclic AMP binding proteins: An independent prognostic factor for disease recurrence and survival in breast cancer
    • Miller, W. R., Watson, D. M. A., Jack, W., Chetty, U., and Elton, R. A., Tumor cyclic AMP binding proteins: An independent prognostic factor for disease recurrence and survival in breast cancer. Breast. Cancer. Res. Treat., 26, 89-94 (1993b).
    • (1993) Breast. Cancer. Res. Treat. , vol.26 , pp. 89-94
    • Miller, W.R.1    Watson, D.M.A.2    Jack, W.3    Chetty, U.4    Elton, R.A.5
  • 51
    • 0030760355 scopus 로고    scopus 로고
    • First- and second-generation antisense inhibitors targeted to human c- raf kinase: In vitro and in vivo studies
    • Monia, B. P., First- and second-generation antisense inhibitors targeted to human c- raf kinase: in vitro and in vivo studies. Anticancer Drug Des., 12, 327-339 (1997).
    • (1997) Anticancer Drug Des. , vol.12 , pp. 327-339
    • Monia, B.P.1
  • 53
    • 0029050664 scopus 로고
    • A single-injection protein kinase A-directed antisense treatment to inhibit humor growth
    • Nesterova, M. and Cho-Chung, Y. S., A single-injection protein kinase A-directed antisense treatment to inhibit humor growth. Nat. Med., 1, 528-633 (1995).
    • (1995) Nat. Med. , vol.1 , pp. 528-633
    • Nesterova, M.1    Cho-Chung, Y.S.2
  • 54
    • 0034537149 scopus 로고    scopus 로고
    • Oligonucleotide sequence-specific inhibition of gene expression, tumor growth inhibition, and modulation of cAMP signaling by an RNA-DNA hybrid antisense targeted to protein kinase A RIα subunit
    • Nesterova, M. and Cho-Chung, Y. S., Oligonucleotide sequencespecific inhibition of gene expression, tumor growth inhibition, and modulation of cAMP signaling by an RNA-DNA hybrid antisense targeted to protein kinase A RIα subunit. Antisense & Nucleic Acid Drug Development, 10, 423-433 (2000).
    • (2000) Antisense & Nucleic Acid Drug Development , vol.10 , pp. 423-433
    • Nesterova, M.1    Cho-Chung, Y.S.2
  • 55
    • 0033623173 scopus 로고    scopus 로고
    • Compensatory stabilization of RIIβ protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-directed down-regulation of protein kinase A RIα protein
    • Nesterova, M., Noguchi, K., Park, Y. G., Lee, Y. N., and Cho-Chung, Y. S., Compensatory stabilization of RIIβ protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-directed down-regulation of protein kinase A RIα protein. Clinical. Cancer. Research, 6, 3434-3441 (2000).
    • (2000) Clinical. Cancer. Research , vol.6 , pp. 3434-3441
    • Nesterova, M.1    Noguchi, K.2    Park, Y.G.3    Lee, Y.N.4    Cho-Chung, Y.S.5
  • 56
    • 0029671412 scopus 로고    scopus 로고
    • Overexpression of RIIβ regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RIIβ
    • Nesterova, M. V., Yokozaki, H., McDuffie, L., and Cho-Chung, Y. S., Overexpression of RIIβ regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RIIβ. Eur. J. Biochem., 235, 486-494 (1996).
    • (1996) Eur. J. Biochem. , vol.235 , pp. 486-494
    • Nesterova, M.V.1    Yokozaki, H.2    McDuffie, L.3    Cho-Chung, Y.S.4
  • 57
    • 0017670013 scopus 로고
    • Structural gene identification and mapping by DNA-mRNA hybrid-arrested cell-free translation
    • Paterson, B. M., Roberts, B. E., and Kuff, E. L., Structural gene identification and mapping by DNA-mRNA hybrid-arrested cell-free translation. Proc. Natl. Acad. Sci. USA, 74, 4370-4374 (1977).
    • (1977) Proc. Natl. Acad. Sci. USA , vol.74 , pp. 4370-4374
    • Paterson, B.M.1    Roberts, B.E.2    Kuff, E.L.3
  • 58
    • 0030273086 scopus 로고    scopus 로고
    • Immune activation by bacterial DNA: A new genetic code
    • Pisetsky, D. S., Immune activation by bacterial DNA: a new genetic code. Immunity, 5, 303-310 (1996).
    • (1996) Immunity , vol.5 , pp. 303-310
    • Pisetsky, D.S.1
  • 59
    • 0028806048 scopus 로고
    • Quantitative monitoring of gene expression patterns with a complementary DNA microarray
    • Schena, M., Shalon, D., Davis, R. W., and Brown, P. O., Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science, 270, 467-470 (1995).
    • (1995) Science , vol.270 , pp. 467-470
    • Schena, M.1    Shalon, D.2    Davis, R.W.3    Brown, P.O.4
  • 60
    • 0029975255 scopus 로고    scopus 로고
    • Telomerase as a potential molecular target to study G-quartet phosphorothioates
    • Sharma, H., Hsiao, W. R., and Narayanan, R., Telomerase as a potential molecular target to study G-quartet phosphorothioates. Antisense Nucleic. Acid Drug Dev., 6, 3-7 (1996).
    • (1996) Antisense Nucleic. Acid Drug Dev. , vol.6 , pp. 3-7
    • Sharma, H.1    Hsiao, W.R.2    Narayanan, R.3
  • 62
    • 0030051727 scopus 로고    scopus 로고
    • Cyclic adenosine 3′,5′-monophosphate-binding proteins in human ovarian cancer: Correlations with clinicapachological features
    • Simpson, B. J. B., Ramage, A. D., Hulme, M. J., Burns, D. J., Katsaros, D., Langdon, S. P., and Miller, W. R., Cyclic adenosine 3′,5′- monophosphate-binding proteins in human ovarian cancer: Correlations with clinicapachological features. Clin. Cancer Res., 2, 201-206 (1996).
    • (1996) Clin. Cancer Res. , vol.2 , pp. 201-206
    • Simpson, B.J.B.1    Ramage, A.D.2    Hulme, M.J.3    Burns, D.J.4    Katsaros, D.5    Langdon, S.P.6    Miller, W.R.7
  • 63
    • 0031813790 scopus 로고    scopus 로고
    • Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase
    • Srivastava, R. K., Srivastava, A. R., Korsmeyer, S. J., Nesterova, M., Cho-Chung, Y. S., and Longo, D. L., Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Mol. Cell Biol., 18, 3509-3517 (1998a).
    • (1998) Mol. Cell Biol. , vol.18 , pp. 3509-3517
    • Srivastava, R.K.1    Srivastava, A.R.2    Korsmeyer, S.J.3    Nesterova, M.4    Cho-Chung, Y.S.5    Longo, D.L.6
  • 64
    • 0031595777 scopus 로고    scopus 로고
    • Antisense depletion of R1-alpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells
    • Srivastava, R. K., Srivastava, A. R., Park, Y. G., Agrawal, S., and Cho-Chung, Y., Antisense depletion of R1-alpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells, Breast Cancer Res. Treat., 49, 97 (1998b).
    • (1998) Breast Cancer Res. Treat. , vol.49 , pp. 97
    • Srivastava, R.K.1    Srivastava, A.R.2    Park, Y.G.3    Agrawal, S.4    Cho-Chung, Y.5
  • 65
    • 0032972572 scopus 로고    scopus 로고
    • Growth arrest and induction of apoptosis in breast cancer cells by antisense depletion of protein kinase A-RI alpha subunit: p53-independent mechanism of action
    • Srivastava, R. K., Srivastava, A. R., Seth, P., Agrawal, S., and Cho-Chung, Y. S., Growth arrest and induction of apoptosis in breast cancer cells by antisense depletion of protein kinase A-RI alpha subunit: p53-independent mechanism of action. Mol. Cell Biochem., 195, 25-36 (1999).
    • (1999) Mol. Cell Biochem. , vol.195 , pp. 25-36
    • Srivastava, R.K.1    Srivastava, A.R.2    Seth, P.3    Agrawal, S.4    Cho-Chung, Y.S.5
  • 66
    • 0003073526 scopus 로고    scopus 로고
    • Antisense inhibition of gene expression
    • V. DeVita, S. Rosenberg and S. Hellman, Eds. New York, Lippincott
    • Stein, C. and Cheng, Y.-A., Antisense inhibition of gene expression, In V. DeVita, S. Rosenberg and S. Hellman, Eds. Principles and Practice of Oncology. New York, Lippincott, pp. 3059-3074 (1997).
    • (1997) Principles and Practice of Oncology , pp. 3059-3074
    • Stein, C.1    Cheng, Y.-A.2
  • 68
    • 0019775444 scopus 로고
    • Turnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMP
    • Steinberg, R. A. and Agard, D. A., Turnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMP. J. Biol. Chem., 256, 10731-10734 (1981).
    • (1981) J. Biol. Chem. , vol.256 , pp. 10731-10734
    • Steinberg, R.A.1    Agard, D.A.2
  • 70
    • 0035845318 scopus 로고    scopus 로고
    • Antisense therapy in oncology: New hope for an old idea?
    • Tamm, I., Dorken, B., and Hartmann, G., Antisense therapy in oncology: new hope for an old idea? Lancet., 358, 489-497 (2001).
    • (2001) Lancet. , vol.358 , pp. 489-497
    • Tamm, I.1    Dorken, B.2    Hartmann, G.3
  • 71
    • 0034130453 scopus 로고    scopus 로고
    • Oral antisense that targets protein kinase A cooperates with taxol and inhibits tumor growth, angiogenesis, and growth factor production
    • Tortora, G., Bianco, R., Damiano, V., Fontanini, G., De Placido, S., Bianco, A. R., and Ciardiello, F., Oral antisense that targets protein kinase A cooperates with taxol and inhibits tumor growth, angiogenesis, and growth factor production. Clin. Cancer Res., 6, 2506-2512 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2506-2512
    • Tortora, G.1    Bianco, R.2    Damiano, V.3    Fontanini, G.4    De Placido, S.5    Bianco, A.R.6    Ciardiello, F.7
  • 73
    • 0030729721 scopus 로고    scopus 로고
    • Synergistic inhibition of human cancer cell growth by cytotoxic drugs and mixed backbone antisense oligonucleotides targeting protein kinase A
    • Tortora, G., Caputo, R., Damiano, V., Bioance, R., Peppe, S., and et al., Synergistic inhibition of human cancer cell growth by cytotoxic drugs and mixed backbone antisense oligonucleotides targeting protein kinase A. Proc. Natl. Acad. Sci. USA, 94, 12586-12591 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 12586-12591
    • Tortora, G.1    Caputo, R.2    Damiano, V.3    Bioance, R.4    Peppe, S.5
  • 74
    • 0024532120 scopus 로고
    • Site-selective 8-chloroadenosine 3′,5′-cyclic monophosphate inhibits transformation and transforming growth factor alpha production in Ki-ras-transformed rat fibroblasts
    • Tortora, G., Ciardiello, F., Ally, S., Clair, T., Salomon, D. S., and Cho-Chung, Y. S., Site-selective 8-chloroadenosine 3′,5′-cyclic monophosphate inhibits transformation and transforming growth factor alpha production in Ki-ras-transformed rat fibroblasts. FEBS Lett., 242, 363-367 (1989).
    • (1989) FEBS Lett. , vol.242 , pp. 363-367
    • Tortora, G.1    Ciardiello, F.2    Ally, S.3    Clair, T.4    Salomon, D.S.5    Cho-Chung, Y.S.6
  • 75
    • 0025823269 scopus 로고
    • Cooperative effect of 8-Cl-cAMP and rhGM-CSF on the differentiation of HL-60 human leukemia cells
    • Tortora, G., Pepe, S., Yokozaki, H., Meissner, S., and Cho-Chung, Y. S., Cooperative effect of 8-Cl-cAMP and rhGMCSF on the differentiation of HL-60 human leukemia cells. Biochem. Biophys. Res. Commun., 177, 1133-1140 (1991a).
    • (1991) Biochem. Biophys. Res. Commun. , vol.177 , pp. 1133-1140
    • Tortora, G.1    Pepe, S.2    Yokozaki, H.3    Meissner, S.4    Cho-Chung, Y.S.5
  • 76
    • 0025980027 scopus 로고
    • Differentiation of HL-60 leukemia cells by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase
    • Tortora, G., Yokozaki, H., Pepe, S., Clair, T., and Cho-Chung, Y. S., Differentiation of HL-60 leukemia cells by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA, 88, 2011-2015 (1991b).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2011-2015
    • Tortora, G.1    Yokozaki, H.2    Pepe, S.3    Clair, T.4    Cho-Chung, Y.S.5
  • 77
    • 33745989225 scopus 로고    scopus 로고
    • Oligonucleotide technologies: Synthesis, production, regulations and applications
    • 29-30th November 2000, Hamburg, Germany
    • Uhlmann, E., Oligonucleotide technologies: synthesis, production, regulations and applications. 29-30th November 2000, Hamburg, Germany. Expert. Opin. Biol. Ther., 1, 319-328 (2001).
    • (2001) Expert. Opin. Biol. Ther. , vol.1 , pp. 319-328
    • Uhlmann, E.1
  • 78
    • 0027750779 scopus 로고
    • Solution structure of a parallel-stranded G-quadruplex DNA
    • Wang, Y. and Patel, D. J., Solution structure of a parallel-stranded G-quadruplex DNA. J. Mol. Biol., 234, 1171-1183 (1993).
    • (1993) J. Mol. Biol. , vol.234 , pp. 1171-1183
    • Wang, Y.1    Patel, D.J.2
  • 79
    • 0034015672 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of Bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma
    • Waters, J. S., Webb, A., Cunningham, D., Clarke, P. A., Raynaud, F., di Stefano, F., and Cotter, F. E., Phase I clinical and pharmacokinetic study of Bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma. J. Clin. Oncol., 18, 1812-1823 (2000).
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1812-1823
    • Waters, J.S.1    Webb, A.2    Cunningham, D.3    Clarke, P.A.4    Raynaud, F.5    Di Stefano, F.6    Cotter, F.E.7
  • 81
    • 0003263350 scopus 로고    scopus 로고
    • G-quartet inhibitory effects of phosphorothioate oligonucleotides
    • L. Rabbani, Eds. Norwell, Kluwer Acad
    • Wyatt, J. R. and Stein, C. A., G-quartet inhibitory effects of phosphorothioate oligonucleotides, In L. Rabbani, Eds. Applications of Antisense Therapies to Restenosis. Norwell, Kluwer Acad (1999).
    • (1999) Applications of Antisense Therapies to Restenosis
    • Wyatt, J.R.1    Stein, C.A.2
  • 82
    • 0032491195 scopus 로고    scopus 로고
    • Novel function of the regulatory subunit of protein kinase A: Regulation of cytochrome c oxidase activity and cytochrome c release
    • Yang, W. L., Iacono, L., Tang, W. M., and Chin, K. V., Novel function of the regulatory subunit of protein kinase A: regulation of cytochrome c oxidase activity and cytochrome c release. Biochemistry, 37, 14175-14180 (1998).
    • (1998) Biochemistry , vol.37 , pp. 14175-14180
    • Yang, W.L.1    Iacono, L.2    Tang, W.M.3    Chin, K.V.4
  • 83
    • 0027499174 scopus 로고
    • An antisense oligodeoxynucleotide that depletes RIα subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells
    • Yokozaki, H., Budillon, A., Tortora, G., Meissner, S., Beaucage, S. L., Miki, K., and Cho-Chung, Y. S., An antisense oligodeoxynucleotide that depletes RIα subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells. Cancer Res., 53, 868-872 (1993).
    • (1993) Cancer Res. , vol.53 , pp. 868-872
    • Yokozaki, H.1    Budillon, A.2    Tortora, G.3    Meissner, S.4    Beaucage, S.L.5    Miki, K.6    Cho-Chung, Y.S.7
  • 85
    • 0041582974 scopus 로고
    • Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
    • Zamecnik, P. and Stephenson, M., Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. USA, 75, 280-284 (1978).
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 280-284
    • Zamecnik, P.1    Stephenson, M.2
  • 86
    • 0003329009 scopus 로고    scopus 로고
    • Growth inhibition of human lung cancer A549 xenografts in nude mice following oral administration of mixed-backbone oligonucleotides targeted at protein kinase A
    • Zhang, R., Zeng, X. F., Bowman, J. D., and Agrawal, S., Growth inhibition of human lung cancer A549 xenografts in nude mice following oral administration of mixed-backbone oligonucleotides targeted at protein kinase A. Proc. Am. Assoc. Cancer Res., 39, 3522 (1998).
    • (1998) Proc. Am. Assoc. Cancer Res. , vol.39 , pp. 3522
    • Zhang, R.1    Zeng, X.F.2    Bowman, J.D.3    Agrawal, S.4
  • 87
    • 0030772278 scopus 로고    scopus 로고
    • Pattern and kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice
    • Zhao, Q., Temsamani, J., Zhou, R. Z., and Agrawal, S., Pattern and kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice. Antisense Nucleic Acid Drug Dev., 7, 495-502 (1997).
    • (1997) Antisense Nucleic Acid Drug Dev. , vol.7 , pp. 495-502
    • Zhao, Q.1    Temsamani, J.2    Zhou, R.Z.3    Agrawal, S.4


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