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Volumn 12, Issue 5, 1997, Pages 359-371

In vitro and in vivo activity of antisense inhibitors of ras: Potential for clinical development

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; ISIS 2503; RAS PROTEIN; UNCLASSIFIED DRUG;

EID: 0030838791     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (39)

References (59)
  • 2
    • 0029124127 scopus 로고
    • Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity
    • AOKI, K., YOSHIDA, T., SUGIMURA, T & TERADA, M. (1995). Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity. Cancer Research, 55, 3810.
    • (1995) Cancer Research , vol.55 , pp. 3810
    • Aoki, K.1    Yoshida, T.2    Sugimura, T.3    Terada, M.4
  • 5
    • 0026010995 scopus 로고
    • Molecular themes in oncogenesis
    • BISHOP, J.M. (1991). Molecular themes in oncogenesis. Cell, 64, 235.
    • (1991) Cell , vol.64 , pp. 235
    • Bishop, J.M.1
  • 7
    • 0027732538 scopus 로고
    • Proteins regulating Ras and its relatives
    • BOGUSKI, M.S. & MCCORMICK, F. (1993). Proteins regulating Ras and its relatives. Nature, 366, 643.
    • (1993) Nature , vol.366 , pp. 643
    • Boguski, M.S.1    Mccormick, F.2
  • 8
    • 0027232605 scopus 로고
    • Emerging concepts in the Ras superfamily of GTP-binding proteins
    • BOKOCH, G.M. & DER, C.J. (1993). Emerging concepts in the Ras superfamily of GTP-binding proteins. FASEB Journal, 7, 750.
    • (1993) FASEB Journal , vol.7 , pp. 750
    • Bokoch, G.M.1    Der, C.J.2
  • 9
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • BOS, J.L. (1989). Ras oncogenes in human cancer: a review. Cancer Research, 49, 4682.
    • (1989) Cancer Research , vol.49 , pp. 4682
    • Bos, J.L.1
  • 12
    • 0029903628 scopus 로고    scopus 로고
    • Antisense oligonucleotides demonstrate a dominant role of c-Ki-ras proteins in regulating the proliferation of diploid human fibroblasts
    • CHEN, G., OH. S . MONIA, B.P. & STACEY, D.W. (1996). Antisense oligonucleotides demonstrate a dominant role of c-Ki-ras proteins in regulating the proliferation of diploid human fibroblasts. Journal of Biological Chemistry, 271, 28259.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 28259
    • Chen, G.1    Oh, S.2    Monia, B.P.3    Stacey, D.W.4
  • 13
    • 0026356572 scopus 로고
    • In vitro toxicology and pharmacokinetics of antisense oligonucleotides
    • CROOKE, R.M. (1991). In vitro toxicology and pharmacokinetics of antisense oligonucleotides. Anticancer Drug Design, 6, 609.
    • (1991) Anticancer Drug Design , vol.6 , pp. 609
    • Crooke, R.M.1
  • 18
    • 0025940096 scopus 로고
    • Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP
    • FARNSWORTH, C L. & FEIG, L A. (1991). Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP. Molecular and Cellular Biology, 11, 4822.
    • (1991) Molecular and Cellular Biology , vol.11 , pp. 4822
    • Farnsworth, C.L.1    Feig, L.A.2
  • 19
    • 0023715225 scopus 로고
    • Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP
    • FEIG, L.A. & COOPER, G.M (1988). Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Molecular and Cellular Biology, 8, 3235.
    • (1988) Molecular and Cellular Biology , vol.8 , pp. 3235
    • Feig, L.A.1    Cooper, G.M.2
  • 21
    • 0027175360 scopus 로고
    • Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct
    • GEORGES, R N., MUKHOPADHYAY, T., ZHANG, Y, YEN, N. & ROTH, J.A. (1993). Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct. Cancer Research, 53, 1743.
    • (1993) Cancer Research , vol.53 , pp. 1743
    • Georges, R.N.1    Mukhopadhyay, T.2    Zhang, Y.3    Yen, N.4    Roth, J.A.5
  • 22
    • 0026541696 scopus 로고
    • Enhanced RNase H activity with methylphosphonodiester/ phosphodiester chimeric antisense oligodeoxynucleotides
    • GILES, R V. & TIDD, D M. (1992). Enhanced RNase H activity with methylphosphonodiester/ phosphodiester chimeric antisense oligodeoxynucleotides. Anticancer Drug Design, 7, 37.
    • (1992) Anticancer Drug Design , vol.7 , pp. 37
    • Giles, R.V.1    Tidd, D.M.2
  • 23
    • 0029157202 scopus 로고
    • Antisense effects of cholesterol-oligodeoxynucleotide conjugates associated with poly(alkylcyanoacrylate) nano-particles
    • GODARD, G., BOUTORINE, A.S , SAISON-BEHMOARAS, E. & HELENE, C. (1995). Antisense effects of cholesterol-oligodeoxynucleotide conjugates associated with poly(alkylcyanoacrylate) nano-particles. European Journal of Biochemistry, 232, 404.
    • (1995) European Journal of Biochemistry , vol.232 , pp. 404
    • Godard, G.1    Boutorine, A.S.2    Saison-Behmoaras, E.3    Helene, C.4
  • 25
    • 0025078512 scopus 로고
    • The cellular functions of small GTP-binding proteins
    • HALL, A. (1990a). The cellular functions of small GTP-binding proteins. Science, 249, 635.
    • (1990) Science , vol.249 , pp. 635
    • Hall, A.1
  • 26
    • 0025373180 scopus 로고
    • Ras and Gap - Who's controlling whom?
    • HALL, A. (1990b). Ras and Gap - who's controlling whom? Cell, 61, 921.
    • (1990) Cell , vol.61 , pp. 921
    • Hall, A.1
  • 27
    • 17144436717 scopus 로고
    • Pharmacology and toxicology of phosphorothioate oligonucleotides in the mouse, rat, monkey and man
    • IVERSEN, P.L., COPPLE, B.L. & TEWARY, H.K. (1995). Pharmacology and toxicology of phosphorothioate oligonucleotides in the mouse, rat, monkey and man. Toxicology Letters, 82, 425.
    • (1995) Toxicology Letters , vol.82 , pp. 425
    • Iversen, P.L.1    Copple, B.L.2    Tewary, H.K.3
  • 29
    • 0028958919 scopus 로고
    • Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro
    • JAMES, G.L., GOLDSTEIN, J.L. & BROWN, M.S. (1995). Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. Journal of Biological Chemistry, 270, 6221.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 6221
    • James, G.L.1    Goldstein, J.L.2    Brown, M.S.3
  • 30
    • 0003896444 scopus 로고
    • Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY
    • KNUDSON, A.G., JR (1977). Origins of Human Cancer. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY
    • (1977) Origins of Human Cancer
    • Knudson Jr., A.G.1
  • 33
    • 0013565075 scopus 로고
    • The ras oncogene
    • Reddy, E., Skalka, A. & Curran T. (eds), Elsevier Press: New York
    • LACAL, J. & TRONICK, S. (1991). The ras oncogene. In The Oncogene Handbook. Reddy, E., Skalka, A. & Curran T. (eds), p. 255. Elsevier Press: New York.
    • (1991) The Oncogene Handbook , pp. 255
    • Lacal, J.1    Tronick, S.2
  • 34
    • 0031060535 scopus 로고    scopus 로고
    • Apoptosis of human BEL-7402 hepatocellular carcinoma cells released by antisense H-ras DNA - In vitro and in vivo studies
    • LIAO, Y, TANG, Z.Y, LIU, K.D., YE, S.L, & HUANG, Z (1997). Apoptosis of human BEL-7402 hepatocellular carcinoma cells released by antisense H-ras DNA - in vitro and in vivo studies. Journal of Cancer Research and Clinical Oncology, 123, 25.
    • (1997) Journal of Cancer Research and Clinical Oncology , vol.123 , pp. 25
    • Liao, Y.1    Tang, Z.Y.2    Liu, K.D.3    Ye, S.L.4    Huang, Z.5
  • 36
    • 0024502703 scopus 로고
    • Ras GTPase activating protein: Signal transmitter and signal terminator
    • MCCORMICK, F (1989). Ras GTPase activating protein: signal transmitter and signal terminator. Cell, 56, 5.
    • (1989) Cell , vol.56 , pp. 5
    • Mccormick, F.1
  • 40
    • 0025868669 scopus 로고
    • Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA
    • MUKHOPADHYAY, T., TAINSKY, M., CAVENDER, A.C. & ROTH, J.A, (1991). Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA. Cancer Research, 51, 1744.
    • (1991) Cancer Research , vol.51 , pp. 1744
    • Mukhopadhyay, T.1    Tainsky, M.2    Cavender, A.C.3    Roth, J.A.4
  • 41
    • 0021970413 scopus 로고
    • Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells
    • MULCAHY, L.S., SMITH, M.R &. STACEY D.W (1985). Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells. Nature, 313, 241.
    • (1985) Nature , vol.313 , pp. 241
    • Mulcahy, L.S.1    Smith, M.R.2    Stacey, D.W.3
  • 43
    • 0024599698 scopus 로고
    • Dominant yeast and mammalian ras mutants that interfere with the CDC25-dependent activation of wild-type ras in Saccharomyces cerevisiae
    • POWERS, S, O'NEILL, K. & WIGLER. M (1989). Dominant yeast and mammalian ras mutants that interfere with the CDC25-dependent activation of wild-type ras in Saccharomyces cerevisiae. Molecular and Cellular Biology, 9, 390.
    • (1989) Molecular and Cellular Biology , vol.9 , pp. 390
    • Powers, S.1    O'Neill, K.2    Wigler, M.3
  • 44
    • 0025733534 scopus 로고
    • Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutant
    • POWERS, S., GONZALES, E , CHRISTENSEN, T. CUBERT, J & BROEK. D (1991). Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutant. Cell, 65, 1225.
    • (1991) Cell , vol.65 , pp. 1225
    • Powers, S.1    Gonzales, E.2    Christensen, T.3    Cubert, J.4    Broek, D.5
  • 45
    • 0028318136 scopus 로고
    • Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton
    • PRENDERGAST, G.G., DAVIDE, J.P., DESOLMS, S.J., GIULIANI, E.A., GRAHAM, S L . GIBBS, J.B., OLIFF, A. & KOHL, N.E. (1994). Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton. Molecular and Cellular Biology, 14, 4193.
    • (1994) Molecular and Cellular Biology , vol.14 , pp. 4193
    • Prendergast, G.G.1    Davide, J.P.2    Desolms, S.J.3    Giuliani, E.A.4    Graham, S.L..5    Gibbs, J.B.6    Oliff, A.7    Kohl, N.E.8
  • 46
    • 0026002058 scopus 로고
    • p21 with a phenylalanine 28-leucine mutation reacts normally with the GTPase activating protein Gap but nevertheless has transforming properties
    • REINSTEIN, J., SCHLICHTING, I., FRECH, M., GOODY, R.S. & WITTINGHOFER, A. (1991). p21 with a phenylalanine 28-leucine mutation reacts normally with the GTPase activating protein Gap but nevertheless has transforming properties. Journal of Biological Chemistry, 266, 17700.
    • (1991) Journal of Biological Chemistry , vol.266 , pp. 17700
    • Reinstein, J.1    Schlichting, I.2    Frech, M.3    Goody, R.S.4    Wittinghofer, A.5
  • 47
    • 0025194466 scopus 로고
    • Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides
    • REISS, Y. GOLDSTEIN, J.L., SEABRA, M.C., CASEY, P.J. & BROWN, M.S. (1990). Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. Cell, 62, 81.
    • (1990) Cell , vol.62 , pp. 81
    • Reiss, Y.1    Goldstein, J.L.2    Seabra, M.C.3    Casey, P.J.4    Brown, M.S.5
  • 48
    • 0025736802 scopus 로고
    • Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation
    • SAISON-BEHMOARAS, T., TOCQUE, B., REY, I., CHASSIGNOL, M., THUONG, N.T. & HELENE, C. (1991). Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation. EMBO Journal, 10, 1111.
    • (1991) EMBO Journal , vol.10 , pp. 1111
    • Saison-Behmoaras, T.1    Tocque, B.2    Rey, I.3    Chassignol, M.4    Thuong, N.T.5    Helene, C.6
  • 49
    • 0028037219 scopus 로고
    • Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice
    • SCHWAB, G., CHAVANY, C., DUROUX, I., GOUBIN, G., LEBEAU, J., HELENE, C. & SAISON-BEHMOARAS, T. (1994). Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice. Proceedings of the National Academy of Sciences of the USA, 91, 10460.
    • (1994) Proceedings of the National Academy of Sciences of the USA , vol.91 , pp. 10460
    • Schwab, G.1    Chavany, C.2    Duroux, I.3    Goubin, G.4    Lebeau, J.5    Helene, C.6    Saison-Behmoaras, T.7
  • 50
    • 0027905014 scopus 로고
    • Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
    • SHIRASAWA, S , FURUSE, M., YOKOYAMA, N & SASAZUKI, T (1993). Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science, 260, 85.
    • (1993) Science , vol.260 , pp. 85
    • Shirasawa, S.1    Furuse, M.2    Yokoyama, N.3    Sasazuki, T.4
  • 52
    • 0028897029 scopus 로고
    • Review of in vivo pharmacokinctics and toxicology of phosphorothioate oligonucleotides
    • SRINIVASAN, S.K. & IVERSEN, P. (1995). Review of in vivo pharmacokinctics and toxicology of phosphorothioate oligonucleotides. Journal of Clinical Laboratory Analysis, 9, 129.
    • (1995) Journal of Clinical Laboratory Analysis , vol.9 , pp. 129
    • Srinivasan, S.K.1    Iversen, P.2
  • 53
    • 0021184853 scopus 로고
    • Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein
    • STACEY, D.W. & KUNG, H.F. (1984). Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein. Nature, 310, 508.
    • (1984) Nature , vol.310 , pp. 508
    • Stacey, D.W.1    Kung, H.F.2
  • 55
    • 0020404981 scopus 로고
    • Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change
    • TAPAROWSKY, E., SUARD, Y., FASANO, O., SHIMIZU, K., GOLDFARB, M. & WIGLER, M. (1982). Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature, 300, 762.
    • (1982) Nature , vol.300 , pp. 762
    • Taparowsky, E.1    Suard, Y.2    Fasano, O.3    Shimizu, K.4    Goldfarb, M.5    Wigler, M.6
  • 56
    • 0023619575 scopus 로고
    • A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants
    • TRAHEY, M. & MCCORMICK, F. (1987). A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science, 238, 542.
    • (1987) Science , vol.238 , pp. 542
    • Trahey, M.1    Mccormick, F.2
  • 57
    • 0021711754 scopus 로고
    • Metabolic turnover of human c-rasH p21 protein of EJ bladder carcinoma and its normal cellular and viral homologs
    • ULSH, L.S. & SHIH, T.Y. (1984). Metabolic turnover of human c-rasH p21 protein of EJ bladder carcinoma and its normal cellular and viral homologs. Molecular and Cellular Biology, 4, 1647.
    • (1984) Molecular and Cellular Biology , vol.4 , pp. 1647
    • Ulsh, L.S.1    Shih, T.Y.2
  • 59
    • 0027759997 scopus 로고
    • Rctroviral Vector-mediated transduction of K.-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype
    • ZHANG, Y., MUKHOPADHYAY, T., DONEHOWER, L.A , GEORGES, R N. & ROTH, J.A. (1993). Rctroviral Vector-mediated transduction of K.-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype. Human Gene Therapy, 4, 451.
    • (1993) Human Gene Therapy , vol.4 , pp. 451
    • Zhang, Y.1    Mukhopadhyay, T.2    Donehower, L.A.3    Georges, R.N.4    Roth, J.A.5


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