Growth arrest and induction of apoptosis in breast cancer cells by antisense depletion of protein kinase A-RIα subunit: p53-independent mechanism of action

Molecular and Cellular Biochemistry

Volumn 195, Issue 1-2, 1999, Pages 25-36

  Srivastava, Rakesh K ^a   Srivastava, Aparna R ^b   Seth, Prem ^b   Agrawal, Sudhir ^c   Cho Chung, Yoon S ^a,b  

^a Lab of Tumor Immunology and Biology   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c HYBRIDON INC   (United States)

Author keywords

Antisense oligonucleotide; Apoptosis; cAMP dependent protein kinase; Cancer cells; Growth inhibition

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLIGONUCLEOTIDE; PROTEIN P53;

APOPTOSIS; ARTICLE; BASE MISPAIRING; BREAST CANCER; CANCER CELL; CELL DIFFERENTIATION; CELL GROWTH; CELL NUCLEUS; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; ENZYME SUBUNIT; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL;

APOPTOSIS; BREAST NEOPLASMS; CELL DIVISION; CELL SURVIVAL; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOWN-REGULATION; GROWTH INHIBITORS; HUMANS; NUCLEOSOMES; OLIGONUCLEOTIDES, ANTISENSE; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0032972572     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006990231186     Document Type: Article

References (39)

1. Krebs EG, Beavo JA: Phosphorylation-dephosphorylation of enzymes. Ann Rev Biochem 88: 923-939, 1979
2. Beebe SJ, Corbin JD: Cyclic nucleotide-dependent protein kinases. In: PD Boyer, EG Krebs (eds). The Enzymes: Control by Phosphorylation, Part A, Vol. 17. Academic Press, New York, 1986, pp 43-111
3. McKnight GS, Clegg CH, Uhler MD, Chrivia JC, Cadd GG, Correll LA, Otten AD: Analysis of the cAMP dependent protein kinase system using molecular genetic approaches. Rec Prog Horm Res 44: 307-335, 1988
4. Levy FO, Øyen O, Sandberg M, Tasken K, Eskild W, Hansson V, Jahnsen T: Molecular cloning, complementary deoxyribonucleic structure and predicted full-length amino aid sequence of the hormone-inducible regulatory subunit of 3¢,5¢-cyclic adenosine monophosphate-dependent protein kinase from human testis. Mol Endocrinol 2: 1364-1373, 1988
5. Lehmann SM, Waiter U: Regulation of the cellular and subcellular concentrations and distribution of cyclic nucleotide-dependent protein kinase. Adv Cyclic Nucleotide Protein Phosphorylation Res 18: 63-117, 1984
6. Cho-Chung YS: Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: New approach to therapy [perspective in cancer research]. Cancer Res 50: 7093-7100, 1990
7. Schwartz DA, Rubin CS: Identification and differential expression of two forms of regulatory subunits (RII) of cAMP-dependent protein kinase II in Friend erythroleukemic cells. J Biol Chem 260: 6296-6303, 1985
8. Tortora G, Yokozaki H, Pepe S, ClairT, Cho-Chung YS: Differentiation of HL-60 leukemia by type 1 regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase. Proc Natl Acad Sci USA 88: 2011-2015, 1991
9. Yokozaki H, Budillon A, Tortora G, Meissner S, Beaucage SL, Miki K, Cho-Chung YS: An antisense oligonucleotide that depletes RIα subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells. Cancer Res 53: 868-872, 1993
10. Nesterova M, Cho-Chung YS: A single-injection protein kinase A-directed antisense treatment to inhibit tumor growth. Nature Medicine 1: 528-533, 1995
11. Bursch W, Oberhammer F, Schulte-Hermann R: Cell death by apoptosis and its protective role against disease. Trends Pharmacol Sci 13: 245-251, 1992
12. Liebermann DA, Hoffman B, Steinman RA: Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways. Oncogene 11: 199-210, 1995
13. Haldar S, Negrini M, Monne M, Sabbioni S, Croce CM: Down-regulation of bcl-2 by p53 in breast cancer cells. Cancer Res 54: 2095-2097, 1994
14. Hockenbery D: Defining apoptosis. Am J Pathol 146: 16-19, 1995
15. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC: Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature (London) 371: 346-347, 1994
16. Martin SJ, Green DR: Protease activation during apoptosis. Death by a thousand cuts? Cell 82: 349-352, 1995
17. Zhang R, Lu Z, Zhao H, Zhang X, Diasio RB, Habus I, Jiang Z, Iyer RP, Yu D, Agrawal S: In vivo stability, disposition and metabolism of a 'hybrid' oligonucleotide phosphorothioate in rats. Biochem Pharmacol 50: 545-546, 1995
18. Fan S, Smith ML, Rivet DJ, Duba D, Zhan Q, Kohn KW, Fornace AJ Jr, O'Conner PM: Disruption of p53 function sensitizes breast cancer cells to cisplatin and pentoxifylline. Cancer Res 55: 1649-1654, 1995
19. Scheffner M, Huibregtse JM, Howley PM: Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. Proc Natl Acad Sci USA 91: 8797-8801, 1994
20. Oberhammer FA, Pavelka M, Shanna S, Tiefenbacher R, Purchio AF, Bursch W, Schulte-Hermann R: Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc Natl Acad Sci USA 89: 5408-5412, 1992
21. Milligan JF, Matteucci MD, Martin JC: Current concepts in antisense drug design. Med Chem 36: 1923-1937, 1993
22. Stein CA, Cheng YC: Antisense oligonucleotides as therapeutic agents-is the bullet really magical? Science 261: 1004-1012, 1993
23. Shibahara S, Mukai S, Morisawa H, Nakashima H, Kobayashi S, Yamamoto N: Inhibition of human immunodeficiency virus (HIV-1) replication by synthetic oligo-RNA derivatives. Nuc Acids Res 17: 239-252, 1989
24. Metelev V, Lisziewiez J, Agrawal S: Study of antisense oligonucleotide phosphorothioates containing segments of oligodeoxynucleotides and 2′-O-methyloligoribonucleotides. Bioorg Med Chem Lett 4: 2929-2934, 1994
25. Monia BP, Lesnik EA, Gonzalez C, Lima WF, McGee D, Guinosso CJ, Kawasaki AM, Cook PD, Freier SM: Evaluation of 2′-modified oligonucleotides containing 2′-deoxygaps as antisense inhibitors of gene expression. J Biol Chem 268: 14514-14522, 1993
26. Fisher DE: Apoptosis in cancer therapy: Crossing the threshold. Cell 78: 539-542, 1994
27. Otten AD, Parenteau LA, Doskeland S, McKnight GS: Hormonal activation of gene transcription in ras transformed NIH3T3 cells overexpressing RIIα and RIIβ subunits of the cAMP-dependent protein kinase. J Biol Chem 266: 23074-23082, 1991
28. Wyllie AH: Cell death: The significance of apoptosis. Int Rev Cytol 5: 131-136, 1980
29. el-Deiry WS, Tokino T, Velculeseu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B: WAF1, a potential mediator of the p53 tumor suppression. Cell 75: 817-825, 1993
30. Kastan MB, Zhan Q, el-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fomace AJ Jr.: A mammalian cell cyclic check point pathway utilizing p53 and GADD45 is defective in ataxia telangiectasia. Cell 71: 587-597, 1992
31. Perry ME, Piette J, Zawadzki JA, Harvey D, Levine A: The mdm-2 gene is induced in response to UV light in a p53-dependent manner. Proc Natl Acad Sci USA 90: 11623-11627, 1993
32. Vaux DL, Cory S, Adams JM: Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440-442, 1988
33. Haldar S, Jena N, DuBois GC, Takayama S, Reed JC, Fu SS, Croce CM: Purification and characterization of bcl-2 protein. Arch Biochem Biophys 315: 483-488, 1994
34. Miyashita T, Reed JC: Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 11: 151-157, 1993
35. Haidar S, Jena N, Croce CM: Inactivation of bcl-2 by phosphorylation. Proc Natl Acad Sci USA 92: 4507-4511, 1995
36. Tortora G, Pepe S, Bianco C, Baldassarre G, Budillon A, Clair T, Cho-Chung YS, Bianco AR, Ciardiello F: The RIα subunit of protein kinase A controls serum dependency and entry into cell cycle of human mammary epithelial cells. Oncogene 9: 3233-3240, 1994
37. 1 phase of nontransformed mammalian cells are absent in transformed cells. Proc Natl Acad Sci USA 89: 8626-8630, 1992
38. Pepe S, Sandomenico C, Damiano V, Ruggiero A, Nesterova M, Bianco AR, Tortora G, Cho-Chung YS: Role of protein kinase A type I (PKAI) in the regulation of HL-60 human promyelocytic leukemia cell cycle kinetics. Proc Am Assoc Cancer Res 37: (abstr) 33, 1996
39. Cvijic ME, Yang W-L, Chin K-V: Cisplatin resistance in cAMP-dependent protein kinase mutants. Pharmacol Ther, 1997 (in press)