Increased expression of the RIα subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer

British Journal of Cancer

Volumn 79, Issue 5-6, 1999, Pages 933-939

  McDaid, H M ^a   Cairns, M T ^a   Atkinson, R J ^a   McAleer, S ^a   Harkin, D P ^a   Gilmore, P ^a   Johnston, P G ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

cAMP; Ovarian cancer; Reverse transcription polymerase chain reaction; Type I cAMP dependent protein kinase

Indexed keywords

ADENOSINE DERIVATIVE; CYCLIC AMP DEPENDENT PROTEIN KINASE; MESSENGER RNA; PLATINUM; REGULATORY SUBUNIT RIALPHA, CYCLIC AMP DEPENDENT PROTEIN KINASE; REGULATORY SUBUNIT RIALPHA, CYCLIC-AMP-DEPENDENT PROTEIN KINASE;

ARTICLE; CANCER CELL CULTURE; CANCER STAGING; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME SUBUNIT; EPITHELIUM TUMOR; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MULTIVARIATE ANALYSIS; OVARY CANCER; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ADENOCARCINOMA; BIOSYNTHESIS; CELL CULTURE; CLASSIFICATION; COLLOID CARCINOMA; CYSTADENOCARCINOMA; ENDOMETRIOID CARCINOMA; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; OVARY TUMOR; PATHOLOGY;

ADENOCARCINOMA, CLEAR CELL; ADENOCARCINOMA, MUCINOUS; CARCINOMA, ENDOMETRIOID; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYSTADENOCARCINOMA, SEROUS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM STAGING; OVARIAN NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0032587480     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690149     Document Type: Article

References (19)

1. Beebe SJ (1994) The cAMP-dependent protein kinases and cAMP signal transduction. Semin Cancer Biol 5: 285-294
2. Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilising the principle of protein-dye binding. Anal Biochem 72: 248-254
3. Cho-Chung YS (1990) Role of cAMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy. Cancer Res 50: 7093-7100
4. Cho-Chung YS (1993) Differentiation therapy of cancer targeting the RIα regulatory subunit of cAMP-dependent protein kinase. Int J Oncol 3: 141-148
5. Land JA (1987) Ovulation, ovulation induction and ovarian carcinoma. Baillières Clin Obstet Gynaecol 43: 455-470
6. Langdon SP, Lawrie SS and Hay FG (1988) Characterisation and properties of nine human ovarian adenocarcinoma cell lines. Cancer Res 48: 6166-6172
7. Leonard MW, Lim K-C and Engel JD (1993) Expression of the chicken GATA factor family during early erythoid development and differentiation. Development 119: 519-531
8. McDaid H, Cairns MT, Church S, White P and Johnston PG (1997) Response to 8-Cl-cAMP in a panel of human cancer cell lines is dependent on intrinsic RIα expression levels. Proc Am Assoc Cancer Res 38: abstract 2823
9. Miller WR, Hulme MJ, McCallum J, Cameron DA, Dixon JM and Bartlett JMS (1996) Tumour RIα mRNA and response to tamoxifen in patients with breast cancer. Proc Am Assoc Cancer Res 37: abstact 1627
10. Nesterova M and Cho-Chung YS (1995) A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth. Nature Med 1: 528-533
11. NIH Consensus Statement (1994) Ovarian cancer: screening, treatment and follow-up. In NIH Consens Statment 12: 1-30
12. Parker SL, Tong T, Bolden S and Wingo PA (1996) Cancer statistics, 1996. CA Cancer Clin 46: 5-27
13. Reimann KV, Walsh DA and Krebs EG (1971) Purification and properties of rabbit skeletal muscle adenosine 3′,5′-monophosphate-dependent protein kinases. J Biol Chem 246: 1986
14. Simpson BJB, Ramage AD, Hulme MJ, Burns DJ, Katsaros D, Langdon SP and Miller WR (1996) Cyclic adenosine 3′,5′-monophosphate-binding proteins in human ovarian cancer: correlations with clinicopathological features. Clin Cancer Res 2: 201-206
15. Tortora G, Ciardiello F, Pepe S, Tagliaferri P, Ruggiero A, Bianco C, Guarrasi R, Miki K and Raffaele Bianco A (1995) Phase I clinical study with 8-Cl-cAMP and evaluation of immunological effects in cancer patients. Clin Cancer Res 51: 1600-1605
16. Van Niekerk CC, Poels LG, Jap PH, Smeets DF, Thomas CM, Ramaekers FC and Voous GP (1988) Characterisation of a human ovarian carcinoma cell line, OTN14 derived from a mucinous cystadenocarcinoma. Int J Cancer 42: 104-111
17. Walsh DA, Perkins JP and Krebs EG (1968) An adenosine 3′,5′-monophosphate-dependent protein kinase from rabbit skeletal muscle. J Biol Chem 243: 3763-3765
18. Whelan SL and Ferlay J (1992) Cancer incidence in five continents. Age-specific and standardized incidence rates. IARC Sci Publ 120: 178-861
19. Wilson AP (1984) Characterisation of a cell line derived from the ascites of a patient with papillary serous cystadenoma of the ovary. J Natl Cancer Inst 72: 513-521