Cocaine acts as an apparent competitive inhibitor at the outward-facing conformation of the human norepinephrine transporter: Kinetic analysis of inward and outward transport

Journal of Neuroscience

Volumn 18, Issue 24, 1998, Pages 10257-10268

  Chen, Nianhang ^a,b   Justice Jr , Joseph B ^a,b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b EMORY UNIVERSITY   (United States)

Author keywords

Cocaine; Dopamine; Efflux; Kinetic analysis; m tyramine; Norepinephrine transporter; Rotating disk voltammetry; Uptake

Indexed keywords

ADRENALIN; COCAINE; DOPAMINE; META TYRAMINE; OUABAIN;

ARTICLE; CATECHOLAMINE UPTAKE; CELL CULTURE; CELL MEMBRANE TRANSPORT; COMPETITIVE INHIBITION; KINETICS; POTENTIOMETRY; PRIORITY JOURNAL;

EID: 0032535582     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-24-10257.1998     Document Type: Article

References (5)

1. Bönisch H, Brüss M (1994) The noradrenaline transporter of the neuronal plasma membrane. Ann NY Acad Sci 733:193-202.
2. Burnette WB, Bailey MD, Kukoyi S, Blakely RD, Trowbridge CG, Justice Jr JB (1996) Human norepinephrine transporter kinetics using rotating disk electrode voltammetry. Anal Chem 68:2932-2938.
3. Calligaro DO, Eldefrawi ME (1987) Central and peripheral cocaine receptors. J Pharmacol Exp Ther 243:61-68.
4. Chen NH, Reith MEA (1994) Effect of locally applied cocaine, lidocaine, and various uptake blockers on monoamine transmission in the ventral tegmental area of freely moving rats: a microdialysis study on monoamine interactions. J Neurochem 63:1701-1703.
5. Chen NH, Reith MEA (1995) Autoregulation and monoamine interactions in the ventral tegmental area in the absence and presence of cocaine: a microdialysis study in freely moving rats. J Pharmacol Exp Ther 271:1597-1610.