The Uptake Inhibitors Cocaine and Benztropine Differentially Alter the Conformation of the Human Dopamine Transporter

Journal of Biological Chemistry

Volumn 276, Issue 31, 2001, Pages 29012-29018

  Reith, Maarten E A ^a   Berfield, Janet L ^a   Wang, Lijuan C ^a   Ferrer, Jasmine V ^b   Javitch, Jonathan A ^b  

^a UNIVERSITY OF ILLINOIS   (United States)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CHEMICAL BONDS; COMPLEXATION; CONFORMATIONS; PROTEINS;

BINDING AFFINITY; INHIBITORY EFFECTS; LIGAND BINDING;

BIOCHEMISTRY;

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; BENZATROPINE; COCAINE; CYSTEINE; DOPAMINE TRANSPORTER; MAZINDOL; THIOL DERIVATIVE; THIOSULFINIC ACID DERIVATIVE; (1R (EXO,EXO)) 3 (4 FLUOROPHENYL) 8 METHYL 8 AZABICYCLO(3.2.1)OCTANE 2 CARBOXYLIC ACID, METHYL ESTER; (1R-(EXO,EXO))-3-(4-FLUOROPHENYL)-8-METHYL-8- AZABICYCLO(3.2.1)OCTANE-2-CARBOXYLIC ACID, METHYL ESTER; CARRIER PROTEIN; DOPAMINE; DOPAMINE UPTAKE INHIBITOR; DRUG DERIVATIVE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; MEMBRANE PROTEIN; MESYLIC ACID DERIVATIVE; METHANETHIOSULFONATE; NERVE PROTEIN; SLC6A3 PROTEIN, HUMAN;

ARTICLE; BEHAVIOR; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; BINDING COMPETITION; BINDING SITE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; KINETICS; METABOLISM; PROTEIN CONFORMATION;

BENZTROPINE; BINDING SITES; BINDING, COMPETITIVE; CARRIER PROTEINS; CELL MEMBRANE; COCAINE; CYSTEINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; HUMANS; INDICATORS AND REAGENTS; KINETICS; MAZINDOL; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MESYLATES; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; PROTEIN CONFORMATION;

EID: 0035800785     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011785200     Document Type: Article

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