Cloning and expression of the mouse serotonin transporter

Molecular Brain Research

Volumn 43, Issue 1-2, 1996, Pages 185-192

  Chang, Albert S ^a,c   Chang, Sharon M ^a   Starnes, Diane M ^a   Schroeter, Sally ^b   Bauman, Andrea L ^b   Blakely, Randy D ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c METROHEALTH MEDICAL CENTER   (United States)

Author keywords

Antidepressant; Cocaine; Ionic dependences; Lipofection; Neurotransmitter transporter; Raphe nuclei

Indexed keywords

ANTIDEPRESSANT AGENT; CARRIER PROTEIN; CHLORIDE ION; CITALOPRAM; COMPLEMENTARY DNA; FLUOXETINE; MEMBRANE PROTEIN; MESSENGER RNA; PAROXETINE; PSYCHOSTIMULANT AGENT; SEROTONIN; SERTRALINE; SODIUM ION; TRITIUM;

AMINE TRANSPORT; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN STEM; CONTROLLED STUDY; GENE EXPRESSION; GENE ISOLATION; IN SITU HYBRIDIZATION; KINETICS; LUNG; MESENCEPHALON; MOLECULAR CLONING; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; RAPHE NUCLEUS; SEQUENCE HOMOLOGY;

ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CLONING, MOLECULAR; GENE EXPRESSION; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

ANIMALIA; MAMMALIA; TRITIUM;

EID: 0030608472     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(96)00172-6     Document Type: Article

References (34)

1. Amara, S.G. and Kuhar, M.J., Neurotransmitter transporters: Recent progress, Annu. Rev. Neurosci., 16 (1993) 73-93.
2. Balkovetz, D.F., Tiruppathi, C., Leibach, F.H., Mahesh, V.B. and Ganapathy, V., Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes, J. Biol. Chem., 264 (1989) 2195-2198.
3. Blakely, R.D., Berson, H.E., Fremeau, R.T., Jr., Caron, M.G., Peek, M.M., Prince, H.K. and Bradley, C.C., Cloning and expression of a functional serotonin transporter from rat brain, Nature, 354 (1991) 66-70.
4. Borowsky, B., Mezey, E. and Hoffman, B.J., Two glycine transporter variants with distinct localization in the CNS and peripheral tissues are encoded by a common gene, Neuron, 10 (1993) 851-863.
5. Chang, A.S., Chang, S.M. and Starnes, D.M., Structure-activity relationships of serotonin transport: Relevance to nontricyclic antidepressant interactions, Eur. J. Pharmacol. Mol. Pharmacol. Sect., 247 (1993) 239-247.
6. Chang, A.S., Frnka, J.V., Chen, D. and Lam, D.M.-K., Characterization of a genetically reconstituted high-affinity system for serotonin transport, Proc. Natl. Acad. Sci. USA, 86 (1989) 9611-9615.
7. Chang, A.S. and Lam, D.M.-K., Mechanistic analyses of ion dependences in high-affinity serotonin transport, J. Physiol., (1996) in press.
8. Cool, D.R., Leibach, F.H., Bhalla, V.K., Mahesh, V.B. and Ganapathy, V., Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR), J. Biol. Chem., 266 (1991) 15750-15757.
9. Feinberg, A.P. and Vogelstein, B., A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity, Anal. Biochem., 132 (1983) 6-13.
10. Frnka, J.V., Chang, A.S. and Lam, D.M.-K., Pharmacological characteristics of high-affinity serotonin uptake systems established through gene transfer, J. Pharmacol. Exp. Ther., 256 (1991) 734-740.
11. Ganapathy, V., Kulanthaivel, P., Tiruppathi, C., Mahesh, V.B. and Leibach, F.H., Inactivation of the human placental serotonin transporter by tyrosyl group-specific reagents, J. Pharmacol. Exp. Ther., 251 (1989) 9-15.
12. 3H ]paroxetine. In N.N. Osborne and M. Hamon (Eds.), Neuronal Serotonin, J. Wiley and Sons, New York, 1988, pp. 367-391.
13. Gregor, P., Patel, A., Shimada, S., Lin, C.-L., Rochelle, J.M., Kitayama, S., Seldin, M.F. and Uhl, G.R., Murine serotonin transporter: Sequence and localization to chromosome 11, Mammalian Genome, 4 (1993) 283-284.
14. Hoffman, B.J., Mezey, E. and Brownstein, M.J., Cloning of a serotonin transporter affected by antidepressants, Science, 254 (1991) 579-580.
15. Humphreys, C.J., Levin, J. and Rudnick, G., Antidepressant binding to the porcine and human platelet serotonin transporters, Mol. Pharmacol., 33 (1988) 657-663.
16. Kanner, B.I., Bioenergetics of neurotransmitter transport, Biochim. Biophys. Acta, 726 (1983) 293-316.
17. Kanner, B.I. and Schuldiner, S., Mechanism of transport and storage of neurotransmitters, CRC Crit. Rev. Biochem., 22 (1987) 1-38.
18. Kemp, B.E. and Pearson, R.B., Protein Kinase recognition sequence motifs, Trends Biochem. Sci., 15 (1990) 342-346.
19. Kimelberg, H.K., Serotonin uptake into astrocytes and its implications. In N.N. Osborne and M. Hamon (Eds.), Neuronal Serotonin, Wiley, New York, 1988, pp. 347-365.
20. Kozak, M., Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs, Nucleic Acids Res., 12 (1984) 857-872.
21. Kyte, J. and Doolittle, R.F., A simple method for displaying the hydropathic character of a protein, J. Mol. Biol., 157 (1982) 105-132.
22. Lee, S.-L. and Fanburg, B.L., Serotonin uptake by bovine artery endothelial cells in culture. I. Characterization, Am. J. Physiol., 250 (1986) C761-C765.
23. Lee, S.L. and Fanburg, B.L., β-Adrenergic antagonists inhibit serotonin uptake by pulmonary vascular cells in culture, J. Pharmacol. Exp. Ther., 257 (1991) 895-900.
24. Lesch, K.-P., Wolozin, B.L., Murphy, D.L. and Riederer, P., Primary structure of the human platelet serotonin uptake site: Identity with the brain serotonin transporter, J. Neurochem., 60 (1993) 2319-2322.
25. Liu, Q.-R., Mandiyan, S., Nelson, H. and Nelson, N., A family of genes encoding neurotransmitter transporters, Proc. Natl. Acad. Sci. USA, 89 (1992) 6639-6643.
26. MacDonald, R.J., Swift, G.H., Przybyla, A.E. and Chirgwin, J.M., Isolation of RNA using guanidinium salts, Methods Enzymol., 152 (1987) 219-227.
27. Myers, C.L., Lazo, J.S. and Pitt, B.R., Translocation of protein kinase C is associated with inhibition of 5-HT uptake by cultured endothelial cells, Am. J. Physiol., 257 (1989) L253-L258.
28. Nelson, P.J. and Rudnick, G., The role of chloride ion in platelet serotonin transport, J. Biol. Chem., 257 (1982) 6151-6155.
29. Ramamoorthy, S., Bauman, A.L., Moore, K.R., Han, H., Yang-Feng, T., Chang, A.S., Ganapathy, V. and Blakely, R.D., Antidepressant- and cocaine-sensitive human serotonin transporter: Molecular cloning, expression, and chromosomal localization, Proc. Natl. Acad. Sci. USA, 90 (1993) 2542-2546.
30. Rudnick, G., Active transport of 5-hydroxytryptamine by plasma membrane vesicles isolated from human blood platelets, J. Biol. Chem., 252 (1977) 2170-2174.
31. Steinbusch, H.W.M., Distribution of serotonin-immunoreactivity in the central nervous system of the rat cell bodies and terminals, Neuroscience, 6 (1981) 557-618.
32. Talvenheimo, J., Fishkes, H., Nelson, P.J. and Rudnick, G., The serotonin transporter- imipramine 'receptor': Different sodium requirements for imipramine binding and serotonin translocation, J. Biol. Chem., 258 (1983) 5115-5119.
33. Uhl, G.R. and Hartig, P.R., Transporter explosion: Update on uptake, Trends Pharmacol. Sci., 13 (1992) 421-425.
34. Wolf, W.A. and Kuhn, D.M., The 5-HT transporter is an additional site of action for the 5-HT agonists RU 24969 and TMFPP, Neurochem. Int., 19 (1991) 39-44.