Serum pharmacology of amphotericin B applied in lipid emulsions

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 4, 1997, Pages 728-732

  Heinemann, Volker ^a   Kähny, Brigitte ^a   Jehn, Ulrich ^a   Mühlbayer, Dieter ^b   Debus, Alexander ^a   Wachholz, Kirsten ^a   Bosse, Daniel ^a   Kolb, Hans Jochem ^a   Wilmanns, Wolfgang ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B;

ADULT; AGED; ANTIFUNGAL ACTIVITY; ARTICLE; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MYCOSIS; PRIORITY JOURNAL;

EID: 0030978653     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.4.728     Document Type: Article

References (16)

1. Bolard, J., P. Legrand, F. Heitz, and B. Cybulska. 1991. One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium. Biochemistry 30:5707-5715.
2. Burch, P. A., J. E. Karp, W. G. Merz, J. E. Kuhlman, and E. K. Fishman. 1987. Favorable outcome of invasive aspergillosis in patients with acute leukemia. J. Clin. Oncol 5:1985-1993.
3. Butler, W. T., and E. Cotlove. 1971. Increased permeability of human erythrocytes induced by amphotericin B. J. Infect. Dis. 123:341-350.
4. Caillot, D., O. Casasnovas, E. Solary, P. Chavanet, B. Bonnette, G. Reny, F. Entezam, J. Lopez, B. Bonnin, and H. Guy. 1993. Efficacy and tolerance of amphotericin B lipid (Intralipid) emulsion in the treatment of candidemia in neutropenic patients. J. Antimicrob. Chemother. 31:161-169.
5. Caillot, D., G. Reny, E. Solary, O. Casasnovas, P. Chavanet, B. Bonnette, L. Perello, M. Dumas, F. Entezam, and H. Guy. 1994. A controlled trial of the tolerance of amphotericin B infused in dextrose or in Intralipid in patients with hematological malignancies. J. Antimicrob. Chemother. 33:603-613.
6. Chavanet, P. Y., I. Garry, N. Charlier, D. Caillot, J.-P. Kisterman, M. D'Athis, and H. Portier. 1992. Trial of glucose versus fat emulsion in preparation of amphotericin B for use in HIV infected patients with candidiasis. B. Med. J. 305:921-925.
7. Feldman, H. A., and J. D. Hamilton. 1973. Amphotericin B therapy in an anephric patient. Antimicrob. Agents Chemother. 4:302-306.
8. Gruda, I., and N. Dussault. 1988. Effect of the aggregation state of amphotericin B on its interaction with ergosterol. Biochem. Cell. Biol. 66:177-183.
9. Heinzel, G., R. Woloszak, and P. Thomann. 1993. Pharmacokinetic and pharmacodynamic data analysis system for the PC. Gustav Fischer, Stuttgart, Germany.
10. Janoff, A. S., L. T. Boni, M. C. Popescu, S. R. Minchey, P. R. Cullis, T. D. Madden, T. Taraschi, S. M. Gruner, E. Shyamsunder, M. W. Tate, R. Mendelsohn, and D. Bonner. 1988. Unusual lipid structures selectively reduce the toxicity of amphotericin B. Proc. Natl. Acad. Sci. USA 85:6122-6126.
11. Janoff, A. S., W. R. Perkins, S, L. Saletan, and C. E. Swenson. 1993. Amphotericin B lipid complex (ABLC™): a molecular rationale for the attenuation of amphotericin B related toxicities. J. Liposome Res. 3:451-471.
12. Joly, V., R. Farinotti, L. Saint-Julien, M. Chéron, C. Carbon, and P. Yeni. 1994. In vitro renal toxicity and in vivo therapeutic efficacy in experimental murine cryptococcosis of amphotericin B (Fungizone) associated with Intralipid. Antimicrob. Agents Chemother. 38:177-183.
13. Khoo, S. H., J. Bond, and D. W. Denning. 1994. Administering amphotericin B - a practical approach. J. Antimicrob. Chemother. 33:203-213.
14. Kirsh, R., R. Goldstein, J. Tarloff, D. Parris, J. Hook, N. Hanna, P. Bugelsky, and G. Poste. 1988. An emulsion formulation of amphotericin B improves the therapeutic index when treating systemic murine candidiasis. J. Infect. Dis. 158:1065-1070.
15. Legrand, P., E. A. Romero, B. E. Cohen, and J. Bolard. 1992. Effects aggregation and solvent on the toxicity of amphotericin B to human erythrocytes. Antimicrob. Agents Chemother. 36:2518-2522.
16. Moreau, P., N. Milpied, N. Fayette, J.-F. Ramée, and J. L. Harousseau. 1992. Reduced renal toxicity and improved clinical tolerance of amphotericin B mixed with Intralipid compared with conventional amphotericin B in neutropenic patients. J. Antimicrob. Chemother. 30:535-541.