Divergent response to LPS and bacteria in CD14-deficient murine macrophages

Journal of Immunology

Volumn 165, Issue 8, 2000, Pages 4272-4280

  Moore, K J ^a   Andersson, L P ^a   Ingalls, R R ^a   Monks, B G ^a   Li, R ^a   Arnaout, M A ^a   Golenbock, D T ^a   Freeman, M W ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD14 ANTIGEN; CD18 ANTIGEN; CYTOCHALASIN B; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NEUTROPHIL INHIBITORY FACTOR; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BACTERIAL MEMBRANE; BACTERIUM ADHERENCE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ESCHERICHIA COLI; GRAM NEGATIVE INFECTION; IMMUNE RESPONSE; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SEPTIC SHOCK; SIGNAL TRANSDUCTION;

EID: 0034667936     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.8.4272     Document Type: Article

References (50)

1. Bacterial endotoxins
2. Biochemistry of endotoxins
3. Current concepts of sepsis and acute lung injury
4. LPS-binding proteins and receptors
5. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
6. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the LPS gene product
7. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
8. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
9. Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide
10. CD18 deficient cells respond to lipopolysaccharide in vitro
11. CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide
12. Outside-in signaling by lipopolysaccharide through a tailless integrin
13. CD11/CD18 leukocyte integrins: New signaling receptors for bacterial endotoxin
14. CD11/CD18 and CD14 share a common lipid A signaling pathway
15. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
16. CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol
17. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages
18. Soluble CD14 promotes LPS activation of CD14-deficient PNH monocytes and endothelial cells
19. Solvent-accessible residues on the metal ion-dependent adhesion site face of integrin CR3 mediate its binding to the neutrophil inhibitory factor
20. Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact
21. Enhanced response of macrophages to CSF-1 in autoimmune mice: A gene transfer strategy
22. CD14-mediated translocation of NF-κB induced by LPS does not require tyrosine kinase activity
23. Soluble CD14 participates in the response of cells to lipopolysaccharide
24. Both membrane-bound and soluble forms of CD14 bind to gram-negative bacteria
25. Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism
26. CR3 (CD11b/CD18) expresses one binding site for Arg-Gly-Asp-containing peptides and a second site for bacterial lipopolysaccharide
27. Human phagocytes have multiple lipid A-binding sites
28. Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor
29. Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: Identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression
30. CD14 dependent and independent signaling pathways in murine macrophages from normal and CD14 'knockout' (CD14KO) mice stimulated with LPS or taxol
31. A mutant of Escherichia coli defective in the first step of endotoxin biosynthesis
32. The toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
33. A comparative analysis of cytokine production and tolerance induction by bacterial lipopeptides, lipopolysaccharides and Staphyloccous aureus in human monocytes
34. CD14 is a cell-activating receptor for bacterial peptidoglycan
35. Cutting edge: Recognition of gram-positive bacterial cell wall components by the innate immune system occurs via toll-like receptor 2
36. Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytic cells via a CD14-dependent pathway distinct from that used by lipopolysaccharide
37. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
38. Cutting edge: Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2
39. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial cell wall products
40. Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures
41. CD14 is a pattern recognition receptor
42. Chemical characteristics of Staphylococcus aureus molecules that have CD14-dependent cell-stimulating activity
43. Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system
44. Ectodomain interactions of leukocyte integrins and pro-inflammatory GPI-linked membrane proteins
45. 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors
46. Integrins as promiscuous signal transduction devices
47. LPS induces CD14 association with complement receptor type 3, which is reversed by neutrophil adhesion
48. Physical association of complement receptor type 3 and urokinase-type plasminogen activator receptor in neutrophil membranes
49. Aberrant capping of membrane proteins on neutrophils from patients with leukocyte adhesion deficiency
50. Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection