Sepsis and evolution of the innate immune response

Critical Care Medicine

Volumn 29, Issue 7 SUPPL., 2001, Pages

  Beutler, B ^a   Poltorak, A ^a   Ulevitch, R ^a   Marshall, J ^a   Giroir, B ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Infection; Innate immunity; Septic shock; Toll like receptor; Tumor necrosis factor

Indexed keywords

BACTERIAL DNA; ENDOTOXIN; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR;

BIOSENSOR; CONFERENCE PAPER; GENETIC VARIABILITY; HUMAN; IMMUNE RESPONSE; INFECTION; MACROPHAGE; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK; SIGNAL TRANSDUCTION;

EID: 0034927826     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200107001-00002     Document Type: Conference Paper

References (30)

1. Endotoxin: Historical perspectives
2. High susceptibility of strain A mice to endotoxin and endotoxin-red blood cell mixtures
3. Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide
4. Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice
5. Genetic control of susceptibility to Salmonella typhimurium in mice: Role of the LPS gene
6. Genetic control of resistance to infection in mice
7. The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxin
8. Passive immunization against cachectin/tumor necrosis factor (TNF) protects mice from the lethal effect of endotoxin
9. Shock and tissue injury induced by recombinant human cachectin
10. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
11. Genetic and physical mapping of the Lps locus-identification of the Toll-4 receptor as a candidate gene in the critical region
12. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
13. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
14. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
15. Limits of a deletion spanning TLR4 in C57BL/10ScCr mice
16. Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor
17. Physical contact between LPS and Tlr4 revealed by genetic complementation
18. The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila
19. A toll-like receptor recognizes bacterial DNA
20. Three novel mammalian toll-like receptors: Gene structure, expression, and evolution
21. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8, and hTLR9
22. Identification of hTLR10: A novel human Toll-like receptor preferentially expressed in immune cells
23. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
24. Endotoxin-mimetic effect of antibodies against Toll-like receptor 4
25. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
26. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
27. Interspecific comparisons reveal conserved features of the Drosophila Toll protein
28. Macrophage differentiation marker MyD88 is a member of the Toll/IL-1 receptor family
29. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
30. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway