Diversity of selective environmental substrates for human cytochrome P450 2A6: Alkoxyethers, nicotine, coumarin, N-nitrosodiethylamine, and N-nitrosobenzylmethylamine

Toxicology Letters

Volumn 144, Issue 1, 2003, Pages 77-91

  Le Gal, Annabelle ^a   Dréano, Yvonne ^a   Lucas, Danièle ^a   Berthou, François ^a  

^a FACULTÉ DE MÉDECINE ET DES SCIENCES DE LA SANTÉ   (France)

Author keywords

Coumarin; CYP2A6; Enzyme kinetics; N Nitrosobenzylmethylamine; Nicotine; Specificity; Substrates

Indexed keywords

CARCINOGEN; CHEMICAL TERATOGEN; COUMARIN; COUMARIN 7 HYDROXYLASE; CYTOCHROME P450 2A6; CYTOCHROME P450 2E1; DIETHYLDITHIOCARBAMIC ACID; DIETHYLNITROSAMINE; METHOXSALEN; N BENZYL N METHYLNITROSAMINE; NICOTINE; TERT BUTYL METHYL ETHER; TROLEANDOMYCIN;

ADULT; CARCINOGENICITY; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INDUCTION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; FEMALE; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME; LIVER TOXICITY; MALE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STRUCTURE ACTIVITY RELATION;

EID: 0043161937     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(03)00229-7     Document Type: Conference Paper

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