Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes

Chemical Research in Toxicology

Volumn 9, Issue 2, 1996, Pages 365-373

  Iribarne, Christelle ^a   Berthou, François ^a   Baird, Susan ^b   Dréano, Yvonne ^a   Picart, Daniel ^a   Bail, Jean Pierre ^c   Beaune, Philippe ^b   Ménez, Jean François ^a  

^a FACULTÉ DE MÉDECINE ET DES SCIENCES DE LA SANTÉ   (France)

^b INSERM   (France)

^c CHU MORVAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA NAPHTHOFLAVONE; CYTOCHROME P450; DIAZEPAM; DIHYDROERGOTAMINE; ERYTHRALOSAMINE; ERYTHROMYCIN; ESTRADIOL; GESTODENE; KETOCONAZOLE; METHADONE; METYRAPONE; NIFEDIPINE; PROADIFEN; QUERCETIN; QUINIDINE; RIFAMPICIN; SULFAPHENAZOLE; TESTOSTERONE; TOREMIFENE;

ARTICLE; DEMETHYLATION; DRUG MECHANISM; DRUG METABOLISM; ENZYME ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROXYLATION; INHIBITION KINETICS; LIVER METABOLISM; LIVER MICROSOME; METHADONE TREATMENT;

CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; KINETICS; METHADONE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION; OXIDOREDUCTASES, N-DEMETHYLATING;

EID: 0029944684     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx950116m     Document Type: Article

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