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Volumn 59, Issue 3, 2003, Pages 269-291

Medicines in the 21st century or pills, politics, potions, and profits: Where is public policy?

Author keywords

Drug discovery process; Health and inequality; Intellectual property; Medicines and public policy

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; DRUG INDUSTRY; ECONOMIC ASPECT; GENOMICS; HEALTH; HEALTH CARE; HEALTH CARE DELIVERY; HEALTH INSURANCE; HUMAN; MALARIA; MEDICINE; PILL; POLICY; POLITICS; PROFIT; PUBLIC HEALTH SERVICE; REVIEW; SANITATION; TUBERCULOSIS;

EID: 0041625711     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10282     Document Type: Review
Times cited : (21)

References (271)
  • 2
    • 0037048941 scopus 로고    scopus 로고
    • The pharmaceutical industry as a political player
    • Abraham J. 2002 The pharmaceutical industry as a political player. Lancet 360:498-1502.
    • (2002) Lancet , vol.360 , pp. 498-1502
    • Abraham, J.1
  • 3
    • 0036139656 scopus 로고    scopus 로고
    • Full-speed mammalian genetics: In vivo target validation in the drug discovery process
    • Abuin A, Holt KH, Platt KA, Sands AT, Zambrowicz BP. 2002. Full-speed mammalian genetics: in vivo target validation in the drug discovery process. Trends Biotechnol 20:36-42.
    • (2002) Trends Biotechnol , vol.20 , pp. 36-42
    • Abuin, A.1    Holt, K.H.2    Platt, K.A.3    Sands, A.T.4    Zambrowicz, B.P.5
  • 4
    • 53349105977 scopus 로고
    • The great American fraud
    • Oct. 7
    • Adams SH. 1905. The great American fraud. Collier's Weekly Oct. 7. www.mtn.org/quack/ephemera/Oct7-01.htm
    • (1905) Collier's Weekly
    • Adams, S.H.1
  • 6
    • 0011553151 scopus 로고    scopus 로고
    • Life science patents enrich academe
    • Oct 14
    • Agres T. 2002. Life science patents enrich academe. Scientist Oct. 14.
    • (2002) Scientist
    • Agres, T.1
  • 8
    • 0037456840 scopus 로고    scopus 로고
    • The world's forgotten crisis
    • Aldhous P. 2003. The world's forgotten crisis. Nature 422:251-253.
    • (2003) Nature , vol.422 , pp. 251-253
    • Aldhous, P.1
  • 9
    • 0344373794 scopus 로고    scopus 로고
    • Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic. The antihypertensive and lipid lowering treatment to prevent heart attack trial (ALLHAT)
    • ALLHAT. 2002. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic. The antihypertensive and lipid lowering treatment to prevent heart attack trial (ALLHAT). JAMA 288:2981-2997.
    • (2002) JAMA , vol.288 , pp. 2981-2997
  • 10
    • 0034702265 scopus 로고    scopus 로고
    • The pharmaceutical industry: To whom is it accountable?
    • Angell M. 2000. The pharmaceutical industry: to whom is it accountable? N Engl J Med 342:1902-1904.
    • (2000) N Engl J Med , vol.342 , pp. 1902-1904
    • Angell, M.1
  • 11
    • 0034682384 scopus 로고    scopus 로고
    • Is academic medicine for sale?
    • Angell M. 2002. Is academic medicine for sale? N Engl J Med 342:1516-1518.
    • (2002) N Engl J Med , vol.342 , pp. 1516-1518
    • Angell, M.1
  • 12
    • 0037132675 scopus 로고    scopus 로고
    • The verdict from ALLHAT: Thiazide diuretics are the preferred initial therapy for hypertension
    • Appel L J. 2002. The verdict from ALLHAT: thiazide diuretics are the preferred initial therapy for hypertension. JAMA 288: 3039-3042.
    • (2002) JAMA , vol.288 , pp. 3039-3042
    • Appel, L.J.1
  • 13
    • 0001270261 scopus 로고    scopus 로고
    • Design by directed evolution
    • Arnold FH. 1998. Design by directed evolution. Acct Chem Res 31:125-131.
    • (1998) Acct Chem Res , vol.31 , pp. 125-131
    • Arnold, F.H.1
  • 14
    • 0035846310 scopus 로고    scopus 로고
    • Lack of health insurance and decline in overall health in late middle age
    • Baker DW, Sudano JL, Albert JM, Borawski EA, Dor A. 2001. Lack of health insurance and decline in overall health in late middle age. N Engl J Med 345:1106-1112.
    • (2001) N Engl J Med , vol.345 , pp. 1106-1112
    • Baker, D.W.1    Sudano, J.L.2    Albert, J.M.3    Borawski, E.A.4    Dor, A.5
  • 15
    • 0034677649 scopus 로고    scopus 로고
    • Reforming the patent system
    • Barton JH. 2000. Reforming the patent system. Science 287: 1933-1934.
    • (2000) Science , vol.287 , pp. 1933-1934
    • Barton, J.H.1
  • 16
    • 0037462593 scopus 로고    scopus 로고
    • IP policies and serving the public
    • Beachy RN. 2003. IP policies and serving the public. Science 299:473.
    • (2003) Science , vol.299 , pp. 473
    • Beachy, R.N.1
  • 18
    • 0042454908 scopus 로고    scopus 로고
    • September 11th. Scientists worldwide protest withdrawal of job offer at U. of Toronto
    • Birchard K. 2001. September 11th. Scientists worldwide protest withdrawal of job offer at U. of Toronto. Chron Higher Education.
    • (2001) Chron Higher Education
    • Birchard, K.1
  • 19
    • 0041954290 scopus 로고    scopus 로고
    • U. of Toronto settles dispute over academic freedom and company-sponsored research
    • Nov. 14
    • Birchard K. 2002. U. of Toronto settles dispute over academic freedom and company-sponsored research. Chron Higher Education Nov. 14.
    • (2002) Chron Higher Education
    • Birchard, K.1
  • 21
    • 0042454910 scopus 로고    scopus 로고
    • The price of knowledge
    • Feb:11
    • Blake CRL. 2001. The price of knowledge. Matrix Feb:11.
    • (2001) Matrix
    • Blake, C.R.L.1
  • 22
    • 0041452823 scopus 로고    scopus 로고
    • Value of university licenses on patents exceeded $1 billion in 2000, survey finds
    • March 5
    • Blumenstyk G. 2002. Value of university licenses on patents exceeded $1 billion in 2000, survey finds. Chron Higher Education March 5.
    • (2002) Chron Higher Education
    • Blumenstyk, G.1
  • 23
    • 0034682156 scopus 로고    scopus 로고
    • Uneasy alliance: Clinical investigators and the pharmaceutical industry
    • Bodenheimer T. 2000. Uneasy alliance: clinical investigators and the pharmaceutical industry. N Engl J Med 342:1539-1544.
    • (2000) N Engl J Med , vol.342 , pp. 1539-1544
    • Bodenheimer, T.1
  • 24
    • 0030039619 scopus 로고    scopus 로고
    • The art and practice of structure-based drug design: A molecular modeling perspective
    • Bohacek RS, McMartin C, Guida WC. 1996. The art and practice of structure-based drug design: a molecular modeling perspective. Med Res Rev 16:3-50.
    • (1996) Med Res Rev , vol.16 , pp. 3-50
    • Bohacek, R.S.1    McMartin, C.2    Guida, W.C.3
  • 27
    • 0041954281 scopus 로고    scopus 로고
    • Industry looks to the Maine chance
    • April 16
    • Bowe C. 2003. Industry looks to the Maine chance. Financial Times (April 16).
    • (2003) Financial Times
    • Bowe, C.1
  • 28
    • 0034329644 scopus 로고    scopus 로고
    • Assessing faculty financial relationships with industry. A case study
    • Boyd EA, Bero LA. 2000. Assessing faculty financial relationships with industry. A case study. JAMA, 284 2209-2214.
    • (2000) JAMA , vol.284 , pp. 2209-2214
    • Boyd, E.A.1    Bero, L.A.2
  • 29
    • 0036941013 scopus 로고    scopus 로고
    • Export your innovations and unlock shareholder value
    • Bradford TC. 2002. Export your innovations and unlock shareholder value. Curr Drug Discov 55-57.
    • (2002) Curr Drug Discov , pp. 55-57
    • Bradford, T.C.1
  • 30
    • 0041452824 scopus 로고    scopus 로고
    • Once a close economic rival of China, India falls behind
    • Nov 29
    • Bradsher K. 2002. Once a close economic rival of China, India falls behind. NY Times (Nov 29) www.nytimes.com
    • (2002) NY Times
    • Bradsher, K.1
  • 31
    • 0037119336 scopus 로고    scopus 로고
    • From protein domains to drug candidates: Natural products as guiding principles in the design and synthesis of compound libraries
    • Breinbauer R, Vetter IR, Waldmann H. 2002. From protein domains to drug candidates: natural products as guiding principles in the design and synthesis of compound libraries. Angewandte Chem Int. Ed 41:2878-2890.
    • (2002) Angewandte Chem Int Ed , vol.41 , pp. 2878-2890
    • Breinbauer, R.1    Vetter, I.R.2    Waldmann, H.3
  • 32
    • 85031525781 scopus 로고    scopus 로고
    • Quoted in Davies K, after the genome: DNA and human disease
    • Brenner S. 2001. Quoted in Davies K, After the genome: DNA and human disease. Cell 104:465-467.
    • (2001) Cell , vol.104 , pp. 465-467
    • Brenner, S.1
  • 33
    • 0038635916 scopus 로고    scopus 로고
    • Problem of lost health benefits is reaching into the middle class
    • Nov 25
    • Broder JM. 2002. Problem of lost health benefits is reaching into the middle class. NY Times Nov 25 www.nytimes.com
    • (2002) NY Times
    • Broder, J.M.1
  • 34
    • 0034077507 scopus 로고    scopus 로고
    • Sequencing the entire genomes of free-living organisms: The foundation of pharmacology in the new millennium
    • Broder S, Venter JC. 2000. Sequencing the entire genomes of free-living organisms: the foundation of pharmacology in the new millennium. Ann Rev Pharmacol Toxicol 40:97-132.
    • (2000) Ann Rev Pharmacol Toxicol , vol.40 , pp. 97-132
    • Broder, S.1    Venter, J.C.2
  • 35
    • 0034531890 scopus 로고    scopus 로고
    • Privatizing the university: The new tragedy of the commons
    • Brown JR. 2000. Privatizing the university: the new tragedy of the commons. Science 290:1701-1702.
    • (2000) Science , vol.290 , pp. 1701-1702
    • Brown, J.R.1
  • 36
    • 0037463173 scopus 로고    scopus 로고
    • The alpha project
    • FEB 14
    • Bunk S. 2003. The alpha project. Scientist Feb 14:24-26.
    • (2003) Scientist , pp. 24-26
    • Bunk, S.1
  • 37
    • 0042955897 scopus 로고    scopus 로고
    • FDA sends letter on Canada drugs
    • March 15
    • Burton TM, Lueck S. 2003. FDA sends letter on Canada drugs. Wall Street J (March 15).
    • (2003) Wall Street J
    • Burton, T.M.1    Lueck, S.2
  • 38
    • 0042508742 scopus 로고    scopus 로고
    • Metabolic engineering: A genetic toolbox for small molecule organic synthesis
    • Burhart MD. 2003. Metabolic engineering: a genetic toolbox for small molecule organic synthesis. Org Biomol Chem 1:1-4.
    • (2003) Org Biomol Chem , vol.1 , pp. 1-4
    • Burhart, M.D.1
  • 39
    • 0036884167 scopus 로고    scopus 로고
    • The rise and analysis of microarray data
    • Butte A. 2002. The rise and analysis of microarray data. Nature Rev Drug Discov 1:951-960.
    • (2002) Nature Rev Drug Discov , vol.1 , pp. 951-960
    • Butte, A.1
  • 40
    • 0032475992 scopus 로고    scopus 로고
    • Harnessing the biosynthetic code: Combinations, permutations, and mutations
    • Cane DE, Walsh CT, Khosla C. 1998. Harnessing the biosynthetic code: combinations, permutations, and mutations. Science 282:63-68.
    • (1998) Science , vol.282 , pp. 63-68
    • Cane, D.E.1    Walsh, C.T.2    Khosla, C.3
  • 43
    • 0035514726 scopus 로고    scopus 로고
    • Growing better blood vessels
    • Carmeliet P, Conway EM. 2001. Growing better blood vessels. Nature Biotech 19:1019-1020.
    • (2001) Nature Biotech , vol.19 , pp. 1019-1020
    • Carmeliet, P.1    Conway, E.M.2
  • 46
    • 0012457983 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research (CDER). 2001. CDER report to the nation: 2001. www.fda.gov/cder/reports/rtn/2001/rtn2001-1.htm
    • (2001) CDER Report to the Nation: 2001
  • 48
    • 0037441560 scopus 로고    scopus 로고
    • Fulfilling the promise: Drug discovery in the post-genomic era
    • Chanda SK, Caldwell HS. 2003. Fulfilling the promise: drug discovery in the post-genomic era. Drug Discov Today Feb:168-174.
    • (2003) Drug Discov Today , vol.FEB , pp. 168-174
    • Chanda, S.K.1    Caldwell, H.S.2
  • 50
    • 0037057620 scopus 로고    scopus 로고
    • Regulators split on gene therapy as patient shows signs of cancer
    • Check E. 2002. Regulators split on gene therapy as patient shows signs of cancer. Nature 419:545-546.
    • (2002) Nature , vol.419 , pp. 545-546
    • Check, E.1
  • 51
    • 0034329877 scopus 로고    scopus 로고
    • Policies on faculty conflicts of interest at US universities
    • Cho MK, Shohara R, Schissel A, Rennie D. 2000. Policies on faculty conflicts of interest at US universities. JAMA 284: 2203-2208.
    • (2000) JAMA , vol.284 , pp. 2203-2208
    • Cho, M.K.1    Shohara, R.2    Schissel, A.3    Rennie, D.4
  • 52
    • 0037011440 scopus 로고    scopus 로고
    • Pharma overview
    • Class S. 2002. Pharma overview. Chem Eng News Dec:39-47. http://pubs.acs.org/CEN
    • (2002) Chem Eng News , vol.DEC , pp. 39-47
    • Class, S.1
  • 54
    • 0037443710 scopus 로고    scopus 로고
    • Of mouse and man: What is the value of the mouse in predicting gene expression in humans?
    • Coleman RA. 2003. Of mouse and man: what is the value of the mouse in predicting gene expression in humans? Drug Discov Today 8:233-235.
    • (2003) Drug Discov Today , vol.8 , pp. 233-235
    • Coleman, R.A.1
  • 55
    • 0041954283 scopus 로고    scopus 로고
    • London, September
    • Commission on Intellectual Property Rights (CIPR). 2002. London, September. www.iprcommission.org
    • (2002)
  • 56
    • 0041954278 scopus 로고    scopus 로고
    • Geneva, Switzerland. Chair, Jeffrey D. Sachs
    • Commission on Macroeconomics and Health. 2001. Investing in health for economic development. Geneva, Switzerland: World Health Organization. Chair, Jeffrey D. Sachs. www3.who.int/whosis/menu.cfm?.path=whosis,cmh&language=english.
    • (2001) Investing in Health for Economic Development
  • 58
    • 0035739895 scopus 로고    scopus 로고
    • Relation between premature mortality and socioeconomic factors in black and white populations of US metropolitan areas
    • Cooper RS, Kennelly JF, Durazo-Arvizu R, Oh HJ, Kaplan G, Lynch J. 2001. Relation between premature mortality and socioeconomic factors in black and white populations of US metropolitan areas. Pub Health Rep 116:464-473.
    • (2001) Pub Health Rep , vol.116 , pp. 464-473
    • Cooper, R.S.1    Kennelly, J.F.2    Durazo-Arvizu, R.3    Oh, H.J.4    Kaplan, G.5    Lynch, J.6
  • 60
    • 18644364558 scopus 로고    scopus 로고
    • Smart weapons prove tough to design
    • Couzin J. 2002. Smart weapons prove tough to design. Science 298:522-525.
    • (2002) Science , vol.298 , pp. 522-525
    • Couzin, J.1
  • 62
    • 0042454899 scopus 로고    scopus 로고
    • Datamonitor. 2002. Big pharma: tightening the marketer's purse strings. www.datamonitor.com. See also M. Peterson, Less return in Marketing of Medicines, a study says. NY Times Dec. 12 www.newyorktimes.com
    • (2002) Big Pharma: Tightening the Marketer's Purse Strings
  • 63
    • 0042955886 scopus 로고    scopus 로고
    • Less return in Marketing of Medicines, a study says
    • Dec 12
    • Datamonitor. 2002. Big pharma: tightening the marketer's purse strings. www.datamonitor.com. See also M. Peterson, Less return in Marketing of Medicines, a study says. NY Times Dec. 12 www.newyorktimes.com
    • NY Times
    • Peterson, M.1
  • 66
    • 0034639220 scopus 로고    scopus 로고
    • A 2020 vision for American health care
    • Davis K, Schoen C, Schoenbaum SC. 2000. A 2020 vision for American health care. Arch Int Med 160:3357-3362.
    • (2000) Arch Int Med , vol.160 , pp. 3357-3362
    • Davis, K.1    Schoen, C.2    Schoenbaum, S.C.3
  • 67
    • 17544377194 scopus 로고    scopus 로고
    • The impact of genomics on drug discovery
    • Debouck C, Metcalf B. 2000. The impact of genomics on drug discovery. Ann Rev Pharmacol Toxicol 40:193-222.
    • (2000) Ann Rev Pharmacol Toxicol , vol.40 , pp. 193-222
    • Debouck, C.1    Metcalf, B.2
  • 71
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DiMasi, JA, Hansen RW, Grabowski HG. 2003. The price of innovation: new estimates of drug development costs. J Health Econ 22:151-185.
    • (2003) J Health Econ , vol.22 , pp. 151-185
    • DiMasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3
  • 72
    • 0034677966 scopus 로고    scopus 로고
    • Drug discovery: A historical perspective
    • Drews J. 2000. Drug discovery: a historical perspective. Science 287:1960-1964.
    • (2000) Science , vol.287 , pp. 1960-1964
    • Drews, J.1
  • 73
    • 0028242546 scopus 로고
    • Molecular nanomachines: Physical principles and implementation strategies
    • Drexler KE. 1994. Molecular nanomachines: physical principles and implementation strategies. Ann Rev Biophys Bioeng 23:377-405.
    • (1994) Ann Rev Biophys Bioeng , vol.23 , pp. 377-405
    • Drexler, K.E.1
  • 80
    • 0042454902 scopus 로고    scopus 로고
    • Technol Q
    • The Economist. 2002c. Innovation's golden goose. Dec:3-30 (Technol Q).
    • (2002) Innovation's Golden Goose , vol.DEC , pp. 3-30
  • 85
    • 0037436107 scopus 로고    scopus 로고
    • Patent swords and shields
    • Eisenberg ES. 2003. Patent swords and shields. Science 299: 1018-1019.
    • (2003) Science , vol.299 , pp. 1018-1019
    • Eisenberg, E.S.1
  • 87
    • 0041954280 scopus 로고    scopus 로고
    • Geneva, Switzerland: Global Forum Health Research, October
    • Feachem R. 2001. Forum 5. Geneva, Switzerland: Global Forum Health Research, October.
    • (2001) Forum 5
    • Feachem, R.1
  • 89
    • 0001691023 scopus 로고
    • There's plenty of room at the bottom
    • Reprinted
    • Feynman RA. 1959. There's plenty of room at the bottom. Reprinted in Science 1991;254:1300-1301.
    • (1959) Science , vol.254 , pp. 1300-1301
    • Feynman, R.A.1
  • 91
    • 0037078774 scopus 로고    scopus 로고
    • The reality of targeted therapies
    • Fogarty M. 2002. The reality of targeted therapies. Scientist Oct 14:35-36.
    • (2002) Scientist , vol.OCT 14 , pp. 35-36
    • Fogarty, M.1
  • 92
    • 0037373590 scopus 로고    scopus 로고
    • New estimates of drug development costs
    • Frank RG. 2003. New estimates of drug development costs. J Health Econ 22:325-330.
    • (2003) J Health Econ , vol.22 , pp. 325-330
    • Frank, R.G.1
  • 94
    • 4243384977 scopus 로고    scopus 로고
    • Amplification of the fittest
    • Freemantle M. 2002. Amplification of the fittest. Chem Eng News Sept 2:31-33.
    • (2002) Chem Eng News , vol.SEPT 2 , pp. 31-33
    • Freemantle, M.1
  • 96
    • 0037030617 scopus 로고    scopus 로고
    • What's ahead for health insurance in the United States?
    • Fuchs VR. 2002. What's ahead for health insurance in the United States? N Engl J Med 346:1822-1824
    • (2002) N Engl J Med , vol.346 , pp. 1822-1824
    • Fuchs, V.R.1
  • 98
    • 0042955893 scopus 로고    scopus 로고
    • Geneva: World Health Organization, Commission on Macroeconomics and Health. Paper no. WG1:10
    • Gallup JL, Sachs JD. 2001. The economic impact of malaria. Geneva: World Health Organization, Commission on Macroeconomics and Health. Paper no. WG1:10.
    • (2001) The Economic Impact of Malaria
    • Gallup, J.L.1    Sachs, J.D.2
  • 99
    • 0037006123 scopus 로고    scopus 로고
    • Medical innovation and institutional interdependence
    • Gelijns AC. Their SO. 2002. Medical innovation and institutional interdependence. JAMA 287:72-77.
    • (2002) JAMA , vol.287 , pp. 72-77
    • Gelijns, A.C.1    Their, S.O.2
  • 100
    • 0042955888 scopus 로고    scopus 로고
    • Molecular Millionaires April 1:23
    • Genetic Engineering News. 2003. Molecular Millionaires April 1:23, no. 7.
    • (2003) Genetic Engineering News , vol.7
  • 101
    • 0037395605 scopus 로고    scopus 로고
    • A brief history of novel drug discovery technologies
    • Gershell LJ, Atkins JH. 2003. A brief history of novel drug discovery technologies. Nature Rev Drug Discov 2:321-327.
    • (2003) Nature Rev Drug Discov , vol.2 , pp. 321-327
    • Gershell, L.J.1    Atkins, J.H.2
  • 102
    • 0042955887 scopus 로고    scopus 로고
    • Global Alliance for TB Drug Development. 2001. Drug development costs. www.tballiance.org
    • (2001) Drug Development Costs
  • 103
    • 0003923554 scopus 로고    scopus 로고
    • Geneva: World Health Organization
    • Global Forum for Health Research. 2002. The 10/90 report on health research 2001-2002. Geneva: World Health Organization. www.globalforumhealth.org
    • (2002) The 10/90 Report on Health Research 2001-2002
  • 104
    • 0034765550 scopus 로고    scopus 로고
    • Research tool patents: Tips for facing a "pay up now or litigate" ultimatum
    • Gogoris A, Ancona P. 2001. Research tool patents: tips for facing a "pay up now or litigate" ultimatum. Nature Biotechnol 19: 1075-1077.
    • (2001) Nature Biotechnol , vol.19 , pp. 1075-1077
    • Gogoris, A.1    Ancona, P.2
  • 105
    • 0042955889 scopus 로고    scopus 로고
    • Made to order
    • M. Goho. 2003. Made to order. MIT Technol Rev April:51-57.
    • (2003) MIT Technol Rev , vol.APRIL , pp. 51-57
    • Goho, M.1
  • 107
    • 0042454900 scopus 로고    scopus 로고
    • The heavy cost of chronic stress
    • Dec 17
    • Goode E. 2002. The heavy cost of chronic stress. NY Times Dec 17.
    • (2002) NY Times
    • Goode, E.1
  • 108
    • 0041452812 scopus 로고    scopus 로고
    • July 11
    • Goodman L. 2002. Celebrity pill pushers. Salon July 11. www.salon.com/mwt/feature/2002/07/11/celebrity_drugs/print.html
    • (2002) Celebrity Pill Pushers
    • Goodman, L.1
  • 109
    • 0042272653 scopus 로고    scopus 로고
    • The price isn't right
    • Goozner M. 2000. The price isn't right. Am Prospect Sept 11(20):25-29.
    • (2000) Am Prospect , vol.SEPT 11 , Issue.20 , pp. 25-29
    • Goozner, M.1
  • 112
    • 0037028111 scopus 로고    scopus 로고
    • Human biology by proxy
    • Gunter C, Dhand R. 2002. Human biology by proxy. Nature 420:509. (The subsequent articles in this issue of Nature detail the mouse genome.)
    • (2002) Nature , vol.420 , pp. 509
    • Gunter, C.1    Dhand, R.2
  • 113
    • 0034060712 scopus 로고    scopus 로고
    • Genetics, genomics and drug discovery
    • Harris T. 2000. Genetics, genomics and drug discovery. Med Res Rev 20:203-211.
    • (2000) Med Res Rev , vol.20 , pp. 203-211
    • Harris, T.1
  • 114
    • 0032076909 scopus 로고    scopus 로고
    • Can patents deter innovation? The anticommons in biomedical research
    • Heller MA, Eisenberg RS. 1998. Can patents deter innovation? The anticommons in biomedical research. Science 280:698-701.
    • (1998) Science , vol.280 , pp. 698-701
    • Heller, M.A.1    Eisenberg, R.S.2
  • 115
    • 0037439570 scopus 로고    scopus 로고
    • Canada rules that transgenic animals are nonpatentable
    • Heller DJ. 2003. Canada rules that transgenic animals are nonpatentable, Genet Eng News March 23:6.
    • (2003) Genet Eng News , vol.MARCH 23 , pp. 6
    • Heller, D.J.1
  • 116
    • 0037121236 scopus 로고    scopus 로고
    • The pharmaceutical industry as a medicines provider
    • Henry D, Lexchin J. 2002. The pharmaceutical industry as a medicines provider. Lancet 360:1590-1596.
    • (2002) Lancet , vol.360 , pp. 1590-1596
    • Henry, D.1    Lexchin, J.2
  • 117
    • 0041452817 scopus 로고    scopus 로고
    • Concern is growing over spike in prices of prescription drugs
    • April 16
    • Hensley S. 2003. Concern is growing over spike in prices of prescription drugs. Wall Street J April 16.
    • (2003) Wall Street J
    • Hensley, S.1
  • 118
    • 0035518014 scopus 로고    scopus 로고
    • Health and human society
    • Hertzman C. 2001. Health and human society. Am Scientist Nov/Dec:538-545.
    • (2001) Am Scientist , vol.NOV-DEC , pp. 538-545
    • Hertzman, C.1
  • 119
    • 33748217278 scopus 로고
    • Artificial replication systems
    • Hoffmann S. 1992. Artificial replication systems. Angewandte Chem Int Ed 31:1013-1016.
    • (1992) Angewandte Chem Int Ed , vol.31 , pp. 1013-1016
    • Hoffmann, S.1
  • 122
    • 0033941034 scopus 로고    scopus 로고
    • Innovation in the pharmaceutical industry
    • Horrobin DF. 2000. Innovation in the pharmaceutical industry. J R Soc Med 93:341-345.
    • (2000) J R Soc Med , vol.93 , pp. 341-345
    • Horrobin, D.F.1
  • 123
    • 0037313517 scopus 로고    scopus 로고
    • Modern biomedical research: An internally self-consistent universe with little contact with medical reality?
    • Horrobin DF. 2003. Modern biomedical research: an internally self-consistent universe with little contact with medical reality? Nature Rev Drug Discov 2:151-154.
    • (2003) Nature Rev Drug Discov , vol.2 , pp. 151-154
    • Horrobin, D.F.1
  • 126
    • 0023427768 scopus 로고
    • Molecular biology and medicinal chemistry
    • Hurley LH. 1987. Molecular biology and medicinal chemistry. J Med Chem 30:7A-8A.
    • (1987) J Med Chem , vol.30
    • Hurley, L.H.1
  • 128
    • 0037191610 scopus 로고    scopus 로고
    • An oral drug for leishmaniasis
    • Jacobs S. 2002. An oral drug for leishmaniasis. N Engl J Med 347:1737-1738.
    • (2002) N Engl J Med , vol.347 , pp. 1737-1738
    • Jacobs, S.1
  • 129
    • 0041452819 scopus 로고    scopus 로고
    • Prescription drug imports
    • March 31 (Letter to Editor)
    • Jander T. 2003. Prescription drug imports. Wall Street J March 31 (Letter to Editor).
    • (2003) Wall Street J
    • Jander, T.1
  • 130
    • 0041954279 scopus 로고    scopus 로고
    • It's time to rethink ephedra regulation
    • March 5
    • Jaroff L. 2003. It's time to rethink ephedra regulation. Time March 5.
    • (2003) Time
    • Jaroff, L.1
  • 131
    • 0030713021 scopus 로고    scopus 로고
    • The Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure
    • Joint National Committee Six. 1997. The Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. Arch Int Med 157:2413-2446.
    • (1997) Arch Int Med , vol.157 , pp. 2413-2446
  • 132
    • 0037248890 scopus 로고    scopus 로고
    • Toil and trouble in the pharma industry
    • Jones E. 2003. Toil and trouble in the pharma industry. Curr Drug Discov January:43-45.
    • (2003) Curr Drug Discov , vol.JANUARY , pp. 43-45
    • Jones, E.1
  • 133
    • 0037126208 scopus 로고    scopus 로고
    • Phylogenetic analysis of 227 human G-protein-coupled reeceptors as a tool for the prediction of orphan receptor ligands
    • Joost P, Methner A. 2002. Phylogenetic analysis of 227 human G-protein-coupled reeceptors as a tool for the prediction of orphan receptor ligands, Genome Biology. At http://genomebiologfy.com/2002/3/11/research/0063.1
    • (2002) Genome Biology
    • Joost, P.1    Methner, A.2
  • 134
    • 0042454897 scopus 로고    scopus 로고
    • The BW Roundtable. Five reasons for cheer on pharma nd one for concern
    • Joseph T. 2002. The BW Roundtable. Five reasons for cheer on pharma nd one for concern. Businessworld October 21:33-42.
    • (2002) Businessworld , vol.OCTOBER 21 , pp. 33-42
    • Joseph, T.1
  • 135
    • 0041506998 scopus 로고    scopus 로고
    • Analysis of the Indian Pharmaceutical Industry. With emphasis on opportunities in 2005
    • Joshi HN. 2003. Analysis of the Indian Pharmaceutical Industry. With emphasis on opportunities in 2005. Pharmaceut Technol January:74-94.
    • (2003) Pharmaceut Technol , vol.JANUARY , pp. 74-94
    • Joshi, H.N.1
  • 136
    • 0026470988 scopus 로고
    • Directed molecular evolution
    • Joyce GF 1992. Directed molecular evolution. Sci Am December:90-97.
    • (1992) Sci Am , vol.DECEMBER , pp. 90-97
    • Joyce, G.F.1
  • 137
    • 0041452810 scopus 로고    scopus 로고
    • Portal Justice. The demography of the death penalty
    • Joynt J, Shuchart C. 2003. Portal Justice. The demography of the death penalty. Atlantic Monthly March:40-41.
    • (2003) Atlantic Monthly , vol.MARCH , pp. 40-41
    • Joynt, J.1    Shuchart, C.2
  • 139
    • 0002110210 scopus 로고    scopus 로고
    • Economic policy is health policy
    • Auerbach JA, Krimgold BK, editors. Washington, DC: National Policy Association Academy for Health Services and Health Policy
    • Kaplan GA. 2000. Economic policy is health policy. In: Auerbach JA, Krimgold BK, editors. Income, socioeconomic status, and health: exploring the relationships. Washington, DC: National Policy Association Academy for Health Services and Health Policy. p 137-148.
    • (2000) Income, Socioeconomic Status, and Health: Exploring the Relationships , pp. 137-148
    • Kaplan, G.A.1
  • 140
    • 0030575501 scopus 로고    scopus 로고
    • Self-replication: Even peptides do it
    • Kauffman SA. 1996. Self-replication: even peptides do it. Nature 382:496-497.
    • (1996) Nature , vol.382 , pp. 496-497
    • Kauffman, S.A.1
  • 142
    • 0032812089 scopus 로고    scopus 로고
    • Dynamic diversity and small molecule evolution: A new paradigm for ligand identification
    • Klekota B, Miller BL. 1999. Dynamic diversity and small molecule evolution: a new paradigm for ligand identification. Trends Biotechnol 17:205-210.
    • (1999) Trends Biotechnol , vol.17 , pp. 205-210
    • Klekota, B.1    Miller, B.L.2
  • 143
    • 0033617520 scopus 로고    scopus 로고
    • Orphan nuclear receptors: Shifting endocrinology into reverse
    • Kliewer SA, Lehmann JM, Willson TM. 1999. Orphan nuclear receptors: shifting endocrinology into reverse. Science 284: 757-760.
    • (1999) Science , vol.284 , pp. 757-760
    • Kliewer, S.A.1    Lehmann, J.M.2    Willson, T.M.3
  • 144
    • 0000096835 scopus 로고    scopus 로고
    • Click chemistry: Diverse chemical function from a few good reactions
    • Kolb HC, Finn MG, Sharpless KB. 2001. Click chemistry: diverse chemical function from a few good reactions. Angewandte Chem Int Ed 40:2004-2021.
    • (2001) Angewandte Chem Int Ed , vol.40 , pp. 2004-2021
    • Kolb, H.C.1    Finn, M.G.2    Sharpless, K.B.3
  • 150
    • 0032820242 scopus 로고    scopus 로고
    • Dynamic combinatorial chemistry and virtual combinatorial libraries
    • Lehn JM. 1999. Dynamic combinatorial chemistry and virtual combinatorial libraries. Chem Eur J 5:2455-2463.
    • (1999) Chem Eur J , vol.5 , pp. 2455-2463
    • Lehn, J.M.1
  • 153
    • 0037087516 scopus 로고    scopus 로고
    • Click chemistry in situ: Acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks
    • Lewis WG, Green LG, Grynszpan F, Radic Z, Caelier PR, Taylor P, Finn MG, Shaepless KB. 2002. Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks. Angewandte Chem Int Ed 41:1053-1054.
    • (2002) Angewandte Chem Int Ed , vol.41 , pp. 1053-1054
    • Lewis, W.G.1    Green, L.G.2    Grynszpan, F.3    Radic, Z.4    Caelier, P.R.5    Taylor, P.6    Finn, M.G.7    Shaepless, K.B.8
  • 154
    • 0041452807 scopus 로고    scopus 로고
    • The effect of new drugs on longevity and quality of life
    • Nov. 15
    • Lichtenberg FR. 2002. The effect of new drugs on longevity and quality of life. LDI Research Seminar Series. Nov. 15. www.upenn.edu/ldi/lichtenberg.html
    • (2002) LDI Research Seminar Series
    • Lichtenberg, F.R.1
  • 155
    • 0037079274 scopus 로고    scopus 로고
    • No agreement reached in talks on access to cheap drugs
    • Loff A. 2002. No agreement reached in talks on access to cheap drugs. Lancet 360:1951.
    • (2002) Lancet , vol.360 , pp. 1951
    • Loff, A.1
  • 156
    • 0042955883 scopus 로고    scopus 로고
    • The health of nations
    • April 16-23
    • Longman PJ. 2003. The health of nations. Wash Monthly April: 16-23.
    • (2003) Wash Monthly
    • Longman, P.J.1
  • 157
    • 0041452805 scopus 로고    scopus 로고
    • From correlation to causation to control: Utilizing preclinical disease models to improve target discovery
    • March/April
    • Lu PY, Xie FY, Scaria P, Woodle MC. 2003. From correlation to causation to control: utilizing preclinical disease models to improve target discovery. Preclinica 31:31-42, March/April. www.preclinica.com
    • (2003) Preclinica , vol.31 , pp. 31-42
    • Lu, P.Y.1    Xie, F.Y.2    Scaria, P.3    Woodle, M.C.4
  • 158
    • 0034633767 scopus 로고    scopus 로고
    • Nucleic acid-triggered catalytic drug release
    • Ma Z, Taylor J-S. 2000. Nucleic acid-triggered catalytic drug release. Proc Natl Acad Sci USA 97:11159-11163.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11159-11163
    • Ma, Z.1    Taylor, J.-S.2
  • 159
    • 0042454890 scopus 로고    scopus 로고
    • Protection racket
    • MacKenzie M. 2001. Protection racket. New Scientist July 21: 18-20.
    • (2001) New Scientist , vol.JULY 21 , pp. 18-20
    • MacKenzie, M.1
  • 160
    • 0037414898 scopus 로고    scopus 로고
    • Universities ask supreme court to reverse patent ruling
    • Malakoff A. 2003. Universities ask supreme court to reverse patent ruling. Science 299:26-27.
    • (2003) Science , vol.299 , pp. 26-27
    • Malakoff, A.1
  • 161
    • 0035957504 scopus 로고    scopus 로고
    • Universities, NIH hear the price isn't right on essential drugs
    • Marshall E. 2001. Universities, NIH hear the price isn't right on essential drugs. Science 292:614-615.
    • (2001) Science , vol.292 , pp. 614-615
    • Marshall, E.1
  • 162
    • 0037123668 scopus 로고    scopus 로고
    • DuPont ups ante on use of Harvard's oncomouse
    • Marshall E. 2002. DuPont ups ante on use of Harvard's oncomouse. Science 296:1212-1213.
    • (2002) Science , vol.296 , pp. 1212-1213
    • Marshall, E.1
  • 163
    • 0034051630 scopus 로고    scopus 로고
    • Malaria on the move: Human population movement and malaria transmission
    • Martens P, Hall L. 2000. Malaria on the move: human population movement and malaria transmission. Emerg Infect Dis 6:7-13.
    • (2000) Emerg Infect Dis , vol.6 , pp. 7-13
    • Martens, P.1    Hall, L.2
  • 165
    • 0042955882 scopus 로고    scopus 로고
    • Drug research walks thin line
    • Jan 1-4
    • McIlroy A. 2001. Drug research walks thin line. Globe Mail Jan 1-4.
    • (2001) Globe Mail
    • McIlroy, A.1
  • 166
    • 0041452808 scopus 로고    scopus 로고
    • McLuhan M. 2003. Cited in www.marshall.mcluhan.com
    • (2003)
    • McLuhan, M.1
  • 169
    • 0036883952 scopus 로고    scopus 로고
    • As biotech turns 20
    • Miller H. 2002. As biotech turns 20. Nature Rev Drug Discov 2:1007-1008.
    • (2002) Nature Rev Drug Discov , vol.2 , pp. 1007-1008
    • Miller, H.1
  • 170
    • 0040074644 scopus 로고    scopus 로고
    • Doctoral education: Another tragedy of the commons?
    • Miller KW, Triggle DJ. 2002. Doctoral education: another tragedy of the commons? Am J Pharmaceut Educ 60:287-294.
    • (2002) Am J Pharmaceut Educ , vol.60 , pp. 287-294
    • Miller, K.W.1    Triggle, D.J.2
  • 171
    • 0037364331 scopus 로고    scopus 로고
    • Biotech's twentieth birthday blues
    • Miska A. 2003. Biotech's twentieth birthday blues. Nature Rev Drug Discov 2:231-233.
    • (2003) Nature Rev Drug Discov , vol.2 , pp. 231-233
    • Miska, A.1
  • 172
    • 0037453967 scopus 로고    scopus 로고
    • Survey suggesting that prescription drug ads help public is met with skepticism
    • Mitka M. 2003. Survey suggesting that prescription drug ads help public is met with skepticism. JAMA 289:827-828.
    • (2003) JAMA , vol.289 , pp. 827-828
    • Mitka, M.1
  • 173
    • 0037070782 scopus 로고    scopus 로고
    • Selling sickness: The pharmaceutical industry and disease mongering
    • Moynihan R, Heath I, Henry D. 2002. Selling sickness: the pharmaceutical industry and disease mongering. BMJ 324: 886-890.
    • (2002) BMJ , vol.324 , pp. 886-890
    • Moynihan, R.1    Heath, I.2    Henry, D.3
  • 174
    • 0037467846 scopus 로고    scopus 로고
    • Biotech vies for position
    • Mullin R. 2003. Biotech vies for position. C & E News Jan 27:27-44.
    • (2003) C & E News , vol.JAN 27 , pp. 27-44
    • Mullin, R.1
  • 175
    • 0035993402 scopus 로고    scopus 로고
    • Computational functional assignment for potential drug targets: From single genes to cellular systems
    • Nagl SB. 2002. Computational functional assignment for potential drug targets: from single genes to cellular systems. Curr Drug Targets 3:387-399.
    • (2002) Curr Drug Targets , vol.3 , pp. 387-399
    • Nagl, S.B.1
  • 176
    • 0037168020 scopus 로고    scopus 로고
    • Academic freedom in clinical research
    • Nathan DG, Weatherall DJ. 2002. Academic freedom in clinical research. N Engl J Med 347:1368-1371.
    • (2002) N Engl J Med , vol.347 , pp. 1368-1371
    • Nathan, D.G.1    Weatherall, D.J.2
  • 179
    • 0042955881 scopus 로고    scopus 로고
    • New Scientist. 2002. The people vs. patents. July 13:3.
    • (2002) The People vs. Patents , vol.JULY 13 , pp. 3
  • 181
    • 0003452435 scopus 로고    scopus 로고
    • September
    • NICHM Foundation. National Institute for Health Care Management Research and Educational Foundation. 2000. Prescription Drugs and Mass Media Advertising, September. www.nihcmorg
    • (2000) Prescription Drugs and Mass Media Advertising
  • 182
    • 0012785515 scopus 로고    scopus 로고
    • May
    • NICHM Foundation, National Institute for Health Care Management Research and Educational Foundation. 2002. Changing patterns of pharmaceutical innovation. May www.nihcm.org
    • (2002) Changing Patterns of Pharmaceutical Innovation
  • 183
    • 0034252556 scopus 로고    scopus 로고
    • Generation of mouse mutants as a tool for functional genomics
    • Nolan PM. 2000. Generation of mouse mutants as a tool for functional genomics. Pharmacogenomics 1:243-255.
    • (2000) Pharmacogenomics , vol.1 , pp. 243-255
    • Nolan, P.M.1
  • 185
    • 0028864511 scopus 로고
    • Combinatorial peptide libraries in drug design: Lessons from venomous cone snails
    • Olivera BM, Hillyard DR, Marsh M, Yoshikami D. 1995. Combinatorial peptide libraries in drug design: lessons from venomous cone snails. Trends Biotech 13:422-426.
    • (1995) Trends Biotech , vol.13 , pp. 422-426
    • Olivera, B.M.1    Hillyard, D.R.2    Marsh, M.3    Yoshikami, D.4
  • 187
    • 0042955875 scopus 로고    scopus 로고
    • March 31
    • Pacotti S. 2003. Are we doomed yet? Salon March 31. www.salon.com/tech/feature/2003/03/31/knowledge/print.html
    • (2003) Are We Doomed Yet?
    • Pacotti, S.1
  • 189
    • 0036780107 scopus 로고    scopus 로고
    • A self-replicating ligase ribozyme
    • Paul N, Joyce GF. 2002. A self-replicating ligase ribozyme. Proc Natl Acad Sci USA 99:12733-12740.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12733-12740
    • Paul, N.1    Joyce, G.F.2
  • 190
    • 0037335308 scopus 로고    scopus 로고
    • Delivering the power of discovery in large pharmaceutical organizations
    • Peakman T, Franks S, White C, Beggs M. 2003. Delivering the power of discovery in large pharmaceutical organizations. Drug Discov Today March:203-211.
    • (2003) Drug Discov Today , vol.MARCH , pp. 203-211
    • Peakman, T.1    Franks, S.2    White, C.3    Beggs, M.4
  • 191
    • 0037011926 scopus 로고    scopus 로고
    • Surviving a knockout blow
    • Pearson H. 2002. Surviving a knockout blow. Nature 415:8-9.
    • (2002) Nature , vol.415 , pp. 8-9
    • Pearson, H.1
  • 192
    • 0036637455 scopus 로고    scopus 로고
    • Should the U.S. allow prescription drug reimports from Canada?
    • Pecorino P. 2003. Should the U.S. allow prescription drug reimports from Canada? J Health Econ 21:699-708.
    • (2003) J Health Econ , vol.21 , pp. 699-708
    • Pecorino, P.1
  • 193
    • 0042454889 scopus 로고    scopus 로고
    • Madison avenue plays growing role in drug research
    • Nov 22
    • Petersen M. 2002. Madison avenue plays growing role in drug research. NY Times Nov 22. www.nytimes.com/2002/11/22/ business/22DRUG.html?pageewanted=print&position=
    • (2002) NY Times
    • Petersen, M.1
  • 197
    • 0035491318 scopus 로고    scopus 로고
    • Knockout drug screens
    • Prendergast G. 2001. Knockout drug screens. Nature Biotechnol 19:919-920.
    • (2001) Nature Biotechnol , vol.19 , pp. 919-920
    • Prendergast, G.1
  • 198
    • 0041452804 scopus 로고    scopus 로고
    • Public Citizen. 2001a. Water for all. www.citizen.org/cmep/water/
    • (2001) Water for All
  • 201
    • 0042955879 scopus 로고    scopus 로고
    • Bayh-Dole reform and the progress of biomedicine
    • Rai AK, Eisenberg RS. 2003. Bayh-Dole reform and the progress of biomedicine Am Scientist Jan-Feb:52-59.
    • (2003) Am Scientist , vol.JAN-FEB , pp. 52-59
    • Rai, A.K.1    Eisenberg, R.S.2
  • 203
    • 0037047577 scopus 로고    scopus 로고
    • Science, sustainability and the human prospect
    • Raven PH. 2002. Science, sustainability and the human prospect. Science 297:954-958.
    • (2002) Science , vol.297 , pp. 954-958
    • Raven, P.H.1
  • 204
    • 0006766961 scopus 로고    scopus 로고
    • London: Weidenfeld and Nicolson
    • Rees M. 1999. Just six numbers. London: Weidenfeld and Nicolson.
    • (1999) Just Six Numbers
    • Rees, M.1
  • 205
  • 206
    • 0041952977 scopus 로고    scopus 로고
    • Patent laws are malleable. Patients are educable. Drug companies are vincible. The world's AIDS crisis is solvable
    • Jan 28
    • Rosenberg T. 2001. Patent laws are malleable. Patients are educable. Drug companies are vincible. The world's AIDS crisis is solvable. NY Times (Magazine) Jan. 28.
    • (2001) NY Times (Magazine)
    • Rosenberg, T.1
  • 208
    • 0038625613 scopus 로고    scopus 로고
    • Generic tide is rising
    • Rouhi AM. 2002a. Generic tide is rising. C & E News Sept 23:37-51.
    • (2002) C & E News , vol.SEPT 23 , pp. 37-51
    • Rouhi, A.M.1
  • 209
    • 65549156271 scopus 로고    scopus 로고
    • Beyond Hatch-Waxman. Legislative action seeks to close loopholes in U.S. law that delay entry of generics into the market
    • Rouhi AM. 2002b. Beyond Hatch-Waxman. Legislative action seeks to close loopholes in U.S. law that delay entry of generics into the market. C & E. News Sept 23:53-65.
    • (2002) C & E News , vol.SEPT 23 , pp. 53-65
    • Rouhi, A.M.1
  • 210
    • 0042454888 scopus 로고    scopus 로고
    • Paying attention to unmet needs
    • Rouhi AM. 2002c. Paying attention to unmet needs. Chem Eng News Sept 23:67-76.
    • (2002) Chem Eng News , vol.SEPT 23 , pp. 67-76
    • Rouhi, A.M.1
  • 211
    • 0345517953 scopus 로고    scopus 로고
    • Genetically modified animals in pharmacological research: Future trends
    • Rudolph U, Mohler H. 1999. Genetically modified animals in pharmacological research: future trends. Eur J Pharmacol 375:327-337.
    • (1999) Eur J Pharmacol , vol.375 , pp. 327-337
    • Rudolph, U.1    Mohler, H.2
  • 213
    • 32644481174 scopus 로고    scopus 로고
    • The essential ingredient
    • Sachs J. 2002a. The essential ingredient. New Scientist Aug 17: 52-55.
    • (2002) New Scientist Aug , vol.17 , pp. 52-55
    • Sachs, J.1
  • 215
    • 0041954272 scopus 로고    scopus 로고
    • March 2
    • Salt Lake Tribune. 2003. Hatch and ephedra. March 2. www.sltrib. com/2003/Mar/03022003/Opinion/Opinion.asp?display=print
    • (2003) Hatch and Ephedra
  • 216
    • 0042453579 scopus 로고    scopus 로고
    • Americans must have access to cheaper Canadian drugs
    • March 16
    • Sanders B (U.S. Congressman). 2003. Americans must have access to cheaper Canadian drugs. Buffalo News March 16. http://bernie.house.gov/documents/opeds/20030318085012.asp?print
    • (2003) Buffalo News
    • Sanders, B.1
  • 218
    • 0030800830 scopus 로고    scopus 로고
    • Construction of a novel virus that targets HIV-1 infected cells and controls HIV-1 infection
    • Schnell MJ, Johnson JE, Buonocore L, Rose JK. 1997. Construction of a novel virus that targets HIV-1 infected cells and controls HIV-1 infection. Cell 90:849-853.
    • (1997) Cell , vol.90 , pp. 849-853
    • Schnell, M.J.1    Johnson, J.E.2    Buonocore, L.3    Rose, J.K.4
  • 219
    • 0042453577 scopus 로고    scopus 로고
    • Special feature. Taking a bite out of the malaria mosquito
    • Science 2002. Special feature. Taking a bite out of the malaria mosquito. 298:77-218.
    • (2002) Science , vol.298 , pp. 77-218
  • 221
    • 0041451500 scopus 로고    scopus 로고
    • Indian pharma companies: Bridging the resource gap
    • in press
    • Shanghvi D. 2003. Indian pharma companies: Bridging the resource gap. Pharmaceut News (in press).
    • (2003) Pharmaceut News
    • Shanghvi, D.1
  • 222
    • 0036749788 scopus 로고    scopus 로고
    • Patenting DNA: A rare exception or the norm?
    • Shirvill J. 2002. Patenting DNA: a rare exception or the norm? Curr Drug Discov Sept:46-49.
    • (2002) Curr Drug Discov , vol.SEPT , pp. 46-49
    • Shirvill, J.1
  • 223
    • 0040018224 scopus 로고    scopus 로고
    • PB&J patent punch-up
    • Shulman S. 2001. PB&J patent punch-up. Technol Rev May:37.
    • (2001) Technol Rev , vol.MAY , pp. 37
    • Shulman, S.1
  • 224
    • 0042955877 scopus 로고    scopus 로고
    • In pursuit of patents
    • February 32-38
    • Singer K. 2001. In pursuit of patents. Matrix February: 32-38.
    • (2001) Matrix
    • Singer, K.1
  • 225
    • 0037457250 scopus 로고    scopus 로고
    • Hitting the target
    • Smith C. 2003. Hitting the target. Nature 422:341-347.
    • (2003) Nature , vol.422 , pp. 341-347
    • Smith, C.1
  • 226
    • 0041954271 scopus 로고    scopus 로고
    • Nanotechnology gains momentum
    • Smith RA. 2001. Nanotechnology gains momentum. Mod Drug Discov April:33-36.
    • (2001) Mod Drug Discov , vol.APRIL , pp. 33-36
    • Smith, R.A.1
  • 227
    • 0008815649 scopus 로고    scopus 로고
    • India's plague
    • Specter M. 2001. India's plague. New Yorker Dec 17:74-85.
    • (2001) New Yorker , vol.DEC 17 , pp. 74-85
    • Specter, M.1
  • 231
    • 0041451502 scopus 로고    scopus 로고
    • Therapeutic monoclonal antibodies: History, facts and trends
    • Takacs L, Vazquez-Abad M.-D, Elliott E. A. 2001. Therapeutic monoclonal antibodies: history, facts and trends. Ann Rep Med Chem 36:237-246.
    • (2001) Ann Rep Med Chem , vol.36 , pp. 237-246
    • Takacs, L.1    Vazquez-Abad, M.-D.2    Elliott, E.A.3
  • 232
    • 0032569205 scopus 로고    scopus 로고
    • Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays
    • Tan TS, Foley MA, Shair MD, Schreiber SL 1998. Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays. J Am Chem Soc 120: 8565-8566.
    • (1998) J Am Chem Soc , vol.120 , pp. 8565-8566
    • Tan, T.S.1    Foley, M.A.2    Shair, M.D.3    Schreiber, S.L.4
  • 233
    • 0036742715 scopus 로고    scopus 로고
    • Application of antisense and siRNAs during preclinical drug development
    • Thompson JD. 2002. Application of antisense and siRNAs during preclinical drug development. Drug Discov Today 7:912-917.
    • (2002) Drug Discov Today , vol.7 , pp. 912-917
    • Thompson, J.D.1
  • 234
    • 0034902213 scopus 로고    scopus 로고
    • Foundations for blockbuster drugs in federally sponsored research
    • Thompson RB. 2001. Foundations for blockbuster drugs in federally sponsored research. FASEB J 15:1671-1676.
    • (2001) FASEB J , vol.15 , pp. 1671-1676
    • Thompson, R.B.1
  • 236
  • 237
    • 0041952975 scopus 로고    scopus 로고
    • Speeding up drug discovery. South Indian entrepreneurs offer contract research services to global pharma
    • Tremblay JF. 2002. Speeding up drug discovery. South Indian entrepreneurs offer contract research services to global pharma. C&E News June 3:13-20.
    • (2002) C&E News , vol.JUNE 3 , pp. 13-20
    • Tremblay, J.F.1
  • 239
    • 0033071625 scopus 로고    scopus 로고
    • Pharmaceutical sciences in the next millennium
    • Triggle DJ. 1999. Pharmaceutical sciences in the next millennium. Ann Pharmacother 33:241-246.
    • (1999) Ann Pharmacother , vol.33 , pp. 241-246
    • Triggle, D.J.1
  • 240
    • 27144541525 scopus 로고    scopus 로고
    • Everybody must get cloned
    • Triggle DJ. 2003a. Everybody must get cloned. Free Inquiry 23: 32-33.
    • (2003) Free Inquiry , vol.23 , pp. 32-33
    • Triggle, D.J.1
  • 241
    • 0037561912 scopus 로고    scopus 로고
    • The 1,4-dihydropyridine nucleus: A pharmacophoric template. Part 1. Actions at ion channels
    • Triggle DJ. 2003b. The 1,4-dihydropyridine nucleus: a pharmacophoric template. Part 1. Actions at ion channels. MiniRev Med Chem 3:217-225.
    • (2003) MiniRev Med Chem , vol.3 , pp. 217-225
    • Triggle, D.J.1
  • 242
    • 0042954569 scopus 로고    scopus 로고
    • Nov. 30. press release may be accessed at csdd.tufts.edu/NewsEvents/RecentNews.asp?newsid=6 2001
    • Tufts Center for the Study of Drug Development. 2001. htttp:// csdd.tufts.edu. Nov. 30. The press release may be accessed at csdd.tufts.edu/NewsEvents/RecentNews.asp?newsid=6 2001.
    • (2001)
  • 243
    • 0037434980 scopus 로고    scopus 로고
    • From proteomics to genomics
    • Tyers M, Mann M. 2003. From proteomics to genomics. Nature 422:193-198.
    • (2003) Nature , vol.422 , pp. 193-198
    • Tyers, M.1    Mann, M.2
  • 244
    • 0041952978 scopus 로고    scopus 로고
    • United Nations Population Division. 2003. www.un.org/esa/population/unpop
    • (2003)
  • 247
    • 0035974798 scopus 로고    scopus 로고
    • Achilles' heel of cancer?
    • Vogelstein B, Kinzler KW. 2001. Achilles' heel of cancer? Nature 412:865-866.
    • (2001) Nature , vol.412 , pp. 865-866
    • Vogelstein, B.1    Kinzler, K.W.2
  • 249
    • 0038497542 scopus 로고
    • A structure for deoxyribose nucleic acid
    • Watson JD, Crick FHC. 1953. A structure for deoxyribose nucleic acid. Nature 171:737-738.
    • (1953) Nature , vol.171 , pp. 737-738
    • Watson, J.D.1    Crick, F.H.C.2
  • 250
    • 0037278248 scopus 로고    scopus 로고
    • The ALLHAT report: A case of information and misinformation
    • Weber MA. 2003. The ALLHAT report: a case of information and misinformation. J Clin Hypertens 5:9-13.
    • (2003) J Clin Hypertens , vol.5 , pp. 9-13
    • Weber, M.A.1
  • 251
    • 0041451497 scopus 로고    scopus 로고
    • Free markets and poverty
    • January 1-14
    • Weller CE, Hersh A. 2002. Free markets and poverty. Am Prospect 13 January 1-14.
    • (2002) Am Prospect , pp. 13
    • Weller, C.E.1    Hersh, A.2
  • 253
    • 0027478912 scopus 로고
    • Peptidomimetics derived from natural products
    • Wiley RA, Rich DH. 1993. Peptidomimetics derived from natural products. Med Res Rev 13:327-384.
    • (1993) Med Res Rev , vol.13 , pp. 327-384
    • Wiley, R.A.1    Rich, D.H.2
  • 255
    • 0035500265 scopus 로고    scopus 로고
    • Gene patents. Socially acceptable monopolies or an unnecessary hindrance to research?
    • Williamson AR. 2001. Gene patents. Socially acceptable monopolies or an unnecessary hindrance to research? Trends Genet 17: 670-673.
    • (2001) Trends Genet , vol.17 , pp. 670-673
    • Williamson, A.R.1
  • 256
    • 0041954270 scopus 로고    scopus 로고
    • Infringement for the public good
    • May
    • Willis RC. 2002. May. Infringement for the public good. Mod Drug Discov May:41-45.
    • (2002) Mod Drug Discov , vol.MAY , pp. 41-45
    • Willis, R.C.1
  • 257
    • 84881497285 scopus 로고    scopus 로고
    • Go forth and multiply
    • Wilson EK. 1998. Go forth and multiply. Chem Eng News Dec 7:40-44.
    • (1998) Chem Eng News , vol.DEC 7 , pp. 40-44
    • Wilson, E.K.1
  • 261
    • 0001803584 scopus 로고    scopus 로고
    • Malaria: A third world disease in need of first world drug discovery
    • Wirth DF. 1999. Malaria: A third world disease in need of first world drug discovery. Ann Rep Med Chem 34:349-358.
    • (1999) Ann Rep Med Chem , vol.34 , pp. 349-358
    • Wirth, D.F.1
  • 262
    • 0037082324 scopus 로고    scopus 로고
    • Target validation of G-protein coupled receptors
    • Wise A, Gearing K, Rees S. 2002. Target validation of G-protein coupled receptors. Drug Discov Today 7:235-246.
    • (2002) Drug Discov Today , vol.7 , pp. 235-246
    • Wise, A.1    Gearing, K.2    Rees, S.3
  • 263
    • 0033539380 scopus 로고    scopus 로고
    • Relation between income inequality and mortality: Empirical demonstration
    • Wolfson M, Kaplan G, Lynch J, Ross, N, Backlund E. 1999. Relation between income inequality and mortality: empirical demonstration. Br Med J 319:953-957.
    • (1999) Br Med J , vol.319 , pp. 953-957
    • Wolfson, M.1    Kaplan, G.2    Lynch, J.3    Ross, N.4    Backlund, E.5
  • 265
    • 0037183163 scopus 로고    scopus 로고
    • The world's most neglected diseases
    • Yamey G. 2002. The world's most neglected diseases. Br Med J 325:176-177.
    • (2002) Br Med J , vol.325 , pp. 176-177
    • Yamey, G.1
  • 267
    • 0037267313 scopus 로고    scopus 로고
    • Knockouts model the 100-best-selling drugs: Will they likely model the next 100?
    • Zambrowicz BP, Sands AT. 2003. Knockouts model the 100-best-selling drugs: will they likely model the next 100? Nature Drug Discov Rev 2:38-51.
    • (2003) Nature Drug Discov Rev , vol.2 , pp. 38-51
    • Zambrowicz, B.P.1    Sands, A.T.2
  • 268
    • 0041451503 scopus 로고    scopus 로고
    • Mail order suppliers under gun
    • Feb 8
    • Zehr L. 2003. Mail order suppliers under gun. Globe and Mail Feb 8. www.workopolis.com/servlet/Content/qprinter/20030208/RGLAX
    • (2003) Globe and Mail
    • Zehr, L.1
  • 269
    • 0035918327 scopus 로고    scopus 로고
    • How do cells sense oxygen?
    • Zhu H, Bunn HF. 2001. How do cells sense oxygen? Science 292:449-451.
    • (2001) Science , vol.292 , pp. 449-451
    • Zhu, H.1    Bunn, H.F.2
  • 270
    • 0037436116 scopus 로고    scopus 로고
    • Tinker, Tailor: Can Venter stitch together a genome from scratch?
    • Zimmer B, 2003. Tinker, Tailor: Can Venter stitch together a genome from scratch? Science 299:1006-1007.
    • (2003) Science , vol.299 , pp. 1006-1007
    • Zimmer, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.