Full-speed mammalian genetics: In vivo target validation in the drug discovery process

Trends in Biotechnology

Volumn 20, Issue 1, 2002, Pages 36-42

  Abuin, Alejandro ^a   Holt, Kathleen H ^a   Platt, Kenneth A ^a   Sands, Arthur T ^a   Zambrowicz, Brian P ^a  

^a LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DOSAGE; DRUG PRODUCTS; GENES; PROTEINS;

GENE SEQUENCE INFORMATION;

GENETIC ENGINEERING;

4 AMINOBUTYRIC ACID; ANTIHYPERTENSIVE AGENT; BENZODIAZEPINE; CYCLOOXYGENASE 1; DIPEPTIDYL CARBOXYPEPTIDASE; ERYTHROPOIETIN; GROWTH HORMONE; NONSTEROID ANTIINFLAMMATORY AGENT;

BIOTECHNOLOGY;

DRUG ACTIVITY; GENE FUNCTION; GENE SEQUENCE; GENE TARGETING; HUMAN; KNOCKOUT MOUSE; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TARGETING; REVIEW; VALIDATION PROCESS;

ANIMALS; CHEMICAL ENGINEERING; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FEMALE; FORECASTING; GENE TARGETING; GENETIC ENGINEERING; GENETIC SCREENING; GENOME, HUMAN; HUMANS; MALE; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; MUTAGENESIS; PHENOTYPE;

MAMMALIA;

EID: 0036139656     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-7799(01)01843-1     Document Type: Review

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