GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine

Journal of Neuroscience

Volumn 17, Issue 1, 1997, Pages 325-333

  Tseng, Jack L ^a   Baetge, E Edward ^b   Zurn, Anne D ^a   Aebischer, Patrick ^a,c  

^a Laboratory of Cellular and Molecular Neurotherapies   (Switzerland)

^b CytoTherapeutics Inc   (United States)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

glial cell line derived neurotrophic factor; medial forebrain bundle axotomy; Parkinson's disease; polymer encapsulation; substantia nigra; tyrosine hydroxylase

Indexed keywords

AMPHETAMINE; COMPLEMENTARY DNA; DOPAMINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; POLYMER; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CELL STRAIN BHK; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOHISTOCHEMISTRY; MEDIAL FOREBRAIN BUNDLE; NERVE FIBER TRANSECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; ROTATION; SUBSTANTIA NIGRA;

EID: 0031031008     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-01-00325.1997     Document Type: Article

References (34)

1. Abercrombie M (1946) Estimation of nuclear population from microtome sections. Anat Rec 94:239-247.
2. Aebischer P, Tresco PA, Winn SR, Greene LA, Jaeger CB (1991) Long-term cross-species brain transplantation of a polymer-encapsulated dopamine-secreting cell line. Exp Neurol 111:269-275.
3. Aebischer P, Schluep M, Déglon N, Joseph JM, Hirt L, Heyd B, Goddard M, Hammang JP, Zurn AD, Kato AC, Regli F, Baetge EE (1996) Intrathecal delivery of CNTF using encapsulated genetically modified xenogenic cells in amyotrophic lateral sclerosis patients. Nat Med 2:696-699.
4. Baetge EE, Suh YH, Joh TH (1986) Complete nucleotide and deduced amino acid sequence of bovine phenylethanolamine N-methyltransferase: partial amino acid homology with rat tyrosine hydroxylase. Proc Natl Acad Sci USA 83:5454-5458.
5. Beck KD, Valverde J, Alexi T, Poulsen K, Moffet B, Vandlen RA, Rosenthal A, Hefti F (1995) Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373:339-341.
6. Björklund A, Lindvall O (1984) Dopamine-containing systems in the CNS. In: Handbook of chemical neuroanatomy, Vol 2, Classical transmitters in the CNS, Pt l (Björklund A, Hökfelt T, eds), pp 55-122. Amsterdam: Elsevier.
7. Bowenkamp KE, Hoffman AF, Gerhardt GA, Henry MA, Biddle PT, Hoffer BJ, Granholm AC (1995) Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. J Comp Neurol 355:479-489.
8. Brecknell JE, Dunnett SB, Fawcett JW (1995) A quantitative study of cell death in the substantia nigra following a mechanical lesion of the medial forebrain bundle. Neuroscience 64:219-227.
9. Brundin P, Lindvall O (1993) Transplantation in Parkinson's disease. In: Restoration of brain function by tissue transplantation (Lindvall O, ed), pp 5-17. Berlin: Springer.
10. Gash DM, Zhang Z, Ovadia A, Cass WA, Yi A, Simmerman L, Russell D, Martin D, Lapchak PA, Collins F, Hoffer BJ, Gerhardt GA (1996) Functional recovery in parkinsonian monkeys treated with GDNF. Nature 380:252-255.
11. Goetz CG, Jankovic J, Paulson GW (1989) Update on Parkinson's disease. Patient Care 23:124-162.
12. Hagg T, Varon S (1993) Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo. Proc Natl Acad Sci USA 90:6315-6319.
13. Henderson CE, Phillips HS, Pollock RA, Davies AM, Lemeulle C, Armanini M, Simpson LC, Moffet B, Vandlen RA, Koliatsos V, Rosenthal A (1994) GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266:1062-1064.
14. Hoffer BJ, Hoffman A, Bowenkamp K, Huettl P, Hudson J, Martin D, Lin LH, Gerhardt GA (1994) Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo. Neurosci Lett 182:107-111.
15. Hudson J, Granholm AC, Gerhardt GA, Henry MA, Hoffman A, Biddle P, Leela NS, Mackerlova L, Lile JD, Collins F, Hoffer BJ (1995) Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo. Brain Res Bull 23:425-432.
16. Humpel C, Hoffer B, Strömberg I, Bektesh S, Collins F, Olson L (1994) Neurons of the hippocampal formation express glial cell line-derived neurotrophic factor messenger RNA in response to kainate-induced excitation. Neuroscience 59:791-795.
17. Jackson EA, Kelly PH (1983) Nigral dopaminergic mechanisms in druginduced circling. Brain Res Bull 11:605-611.
18. Kearns CM, Gash DM (1995) GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo. Brain Res 672:104-111.
19. Knüsel B, Beck KD, Winslow JW, Rosenthal A, Burton LE, Widmar HR, Nikolics K, Hefti F (1992) Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain. J Neurosci 12:4391-4402.
20. Kozlowski MR, Sawyer S, Marshall JF (1980) Behavioural effects and supersensitivity following nigral dopamine receptor stimulation. Nature 287:52-54.
21. 2 receptors mediate the behaviqral effects of dopamine agonists. Behav Brain Res 38:233-242.
22. Lapchak PA, Beck KD, Araujo DM, Irwin I, Langston JW, Hefti F (1993) Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection. Neuroscience 14:639-650.
23. Li L, Wu W, Lin LH, Lei M, Oppenheim RW, Houenou LJ (1995) Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor. Proc Natl Acad Sci USA 92:9771-9775.
24. Lin LH, Doherty DH, Lile JD, Bektesh S, Collins F (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130-1132.
25. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. San Diego: Academic.
26. Ruffieux A, Schultz W (1980) Dopaminergic activation of reticulata neurones in the substantia nigra. Nature 285:240-241.
27. Sagot Y, Tan SA, Hammang JP, Aebischer PA, Kato AC (1996) GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice. J Neurosci 16:2335-2341.
28. Sauer H, Rosenblad C, Björklund A (1995) Glial cell line-derived neurotrophic factor but not TGF-β3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion. Proc Natl Acad Sci USA 92:8935-8939.
29. Schaar DG, Sieber BA, Dreyfus CF, Black IB (1993) Regional and cell-specific expression of GDNF in rat brain. Exp Neurol 124:368-371.
30. Springer JE, Mu X, Bergmann LW, Trojanowski JQ (1994) Expression of GDNF mRNA in rat and human nervous tissue. Exp Neurol 127:167-170.
31. Strömberg I, Björklund L, Johansson M, Tomac A, Collins F, Olson L, Hoffer B, Humpel C (1993) Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo. Exp Neurol 124:401-412.
32. Tomac A, Lindqvist E, Lin LH, Ögren SO, Young D, Hoffer BJ, Olson L (1995) Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373:335-339.
33. Yan Q, Matheson C, Lopez OT (1995) In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature 373:341-344.
34. Zurn AD, Baetge EE, Hammang JP, Tan SA, Aebischer P (1994) Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones. NeuroReport 6:113-118.