Neuropathology of fetal nigral crafts in patients with Parkinson's disease

Movement Disorders

Volumn 13, Issue SUPPL. 1, 1998, Pages 88-95

  Kordower, Jeffrey H ^a   Freeman, Thomas B ^b   Olanow, C Warren ^c  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFERENCE PAPER; FETAL TISSUE TRANSPLANTATION; GRAFT SURVIVAL; HUMAN; NEUROPATHOLOGY; PARKINSON DISEASE; PRIORITY JOURNAL;

ADULT; AGED; ANIMALS; CLINICAL TRIALS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINE; FEMALE; FETAL TISSUE TRANSPLANTATION; GRAFT SURVIVAL; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE; SUBSTANTIA NIGRA; TREATMENT OUTCOME;

EID: 0031947943     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (29)

1. Calne DB. Treatment of Parkinson's disease. N Engl J Med 1993; 329:1021-1027.
2. Bjorklund A, Stenevi U. Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res 1979; 177:555-560.
3. Bjorklund A, Stenevi U, Dunnett SB, Iverson L. Functional reactivation of the deafferented neostriatum by nigral transplants. Nature 1981;289:497-499.
4. Brundin P, Bjorklund A. Survival, growth and function of dopaminergic neurons grafted to the brain. Prog Brain Res 1987;71: 293-308.
5. Dunnett SB, Bjorklund A, Stenevi U, Iversen SD. Behavioral recovery following transplantation of substantia nigra in rats subjected to 6-OHDA lesions of the nigrostriatal pathway. Brain Res 1981;215:147-161.
6. Dunnett SB, Bjorklund A, Schmidt RH, Stenevi U, Iversen SD. Intracerebral grafting of neuronal cell suspensions, IV: behavioral recovery in rats with unilateral 6-OHDA lesions following implantation of nigral cell suspensions in different forebrain sites. Acta Physiol Scand 1983;S522:29-37.
7. Freed WJ, Perlow MJ, Karoum F, et al. Restoration of dopamine brain function by grafting fetal substantia nigra to the caudate nucleus: long term behavioral, biochemical, and histological studies. Ann Neurol 1980;8:510-523.
8. Perlow MJ, Freed WJ, Hoffer BJ, Seiger A, Olson L, Wyatt RJ. Brain grafts reduce motor abnormalities produced by destruction of nigro-striatal dopamine system. Science 1979;204:643-647.
9. Kordower JH, Schueler SB, Bredesen D, et al. Neural grafting for Parkinson's disease: an evaluation of dopaminergic donor tissues. In: Marwah J, Teitlebaum H, Prasad H, eds. Neural transplantation, CNS neuronal injury, and regeneration: Recent advances. Boca Raton, FL: CRC Press, 1994:17-37.
10. Clarke DJ, Brundin P, Strecker R, Nilsson O, Bjorklund A, Lindvall O. Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: ultrastructural evidence for synapse formation using tyrosine hydroxylase immunocytochemistry. Exp Brain Res 1988;73:115-129.
11. Brundin P, Widner H, Nilsson OG, Strecker RE, Bjorklund A. Intracerebral xenografts of dopamine neurons: the role of immunosuppression and the blood-brain barrier. Exp Brain Res 1989; 75:195-207.
12. Dunnett SB, Hernandez TD, Summerfield A, Jones GH, Arbuthnott G. Graft-derived recovery from 6-OHDA lesions: specificity of ventral mesencephalic graft tissues. Exp Brain Res 1988;71: 411-424.
13. Freed WJ, Morihisa JM, Spoor E, et al. Transplanted adrenal chromaffin cells in rat brain reduce lesion-induced rotational behavior. Nature 1981;292:351-352.
14. Freed WJ, Cannon-Spoor HE, Krauthamer E. Intrastriatal adrenal medulla grafts in rats: long-term survival and behavioral effects. J Neurosurg 1986;65:664-670.
15. Stromberg I, Herrera-Marschitz M, Ungerstedt U, Ebendal T, Olson L. Chronic implants of chromaffin tissue into the dopamine-denervated striatum. Effects of NGF on graft survival, fiber growth and rotational behavior. Exp Brain Res 1985;60:335-349.
16. Date I, Felten SY, Felten DL. Cografts of adrenal medulla with peripheral nerve enhance the survivability of transplanted adrenal chromaffin cells and recovery of the host nigrostriatal dopaminergic system in MPTP-treated young adult mice. Brain Res 1990; 537:33-39.
17. Date I, Furukawa S, Ohmoto T. Increased nerve growth factor level in the distal stump of transected sciatic nerve in relation to aging and its application for neural grafting. Exp Neurol 1994;130: 168-171.
18. Date I, Imaoka T, Miyoshi Y, Ono T, Asari S, Ohmoto T. Chromaffin cell survival and host dopaminergic fiber recovery in a patient with Parkinson's disease treated by cografts of adrenal medulla and pretransected peripheral nerve. J Neurosurg 1996;84: 685-689.
19. Date I, Ohmoto T. Neural transplantation and trophic factors in Parkinson's disease: special reference to chromaffin cell grafting, NGF support form pretransected peripheral nerve, and encapsulated dopamine-secreting cell grafting. Exp Neurol 1996;137:333-344.
20. Kordower JH, Fiandaca MS, Notter MFD, Hansen JT, Gash DM. NGF-like trophic support form peripheral nerve for grafted rhesus adrenal chromaffin cells. J Neurosurg 1990;73:418-428.
21. Freeman TB, Olanow CW, Hauser RA, et al. Bilateral fetal nigral transplantation into the post-commissural putamen as a treatment for Parkinson's disease: six month follow-up. Ann Neurol 1995; 38:379-388.
22. Kordower JH, Freeman TB, Snow BJ, et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med 1995;332:1118-1124.
23. Kordower JH, Rosenstein JM, Collier TJ, et al. Functional fetal nigral grafts in a patient with Parkinson's disease: chemoanatomic, ultrastructural, and metabolic studies. J Comp Neurol 1996;370: 203-230.
24. Kordower JH, Freeman TB, Chen E-Y, et al. Fetal nigral grafts survive and mediate clinical benefit in PD. Mov Disord. In press.
25. Kordower JH, Rosenstein JM, Collier TJ, et al. Functional fetal nigral grafts in a second patient with Parkinson's disease: a post-mortem analysis. Soc Neurosci Abstr 1996;22:318.
26. Redmond DE Jr, Leranth C, Spencer DD, et al. Fetal neural graft survival. Lancet 1990;336:820-822.
27. Hitchcock EH, Whitwell HL, Sofroniew MV, Bankiewicz KS. Survival of TH-positive and neuromelanin-containing cells in patients with Parkinson's disease after intrastriatal grafting of fetal ventral mesencephalon [Abstract]. Exp Neurol 1994;129:3.
28. Folkerth RD, Durso R. Survival and proliferation of nonneural tissues, with obstruction of cerebral ventricles, in a parkinsonian patient treated with fetal allografts. Neurology 1996;46:1219-1224.
29. Kordower JH, Styren S, DeKosky S, Freeman TB, Olanow CW. Fetal grafting for Parkinson's disease: expression of immune markers in two patients with functional fetal nigral implants. Cell Transplantation 1997;6:213-219.