Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat

Proceedings of the National Academy of Sciences of the United States of America

Volumn 91, Issue 11, 1994, Pages 5104-5108

  Frim, David M ^a,c   Uhler, Tara A ^a   Galpern, Wendy R ^a,d   Beal, M Flint ^c   Breakefield, Xandra O ^b,c   Isacson, Ole ^a,b,c  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

neuroprotection; substantia nigra

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; MITOCHONDRIAL ENZYME; NERVE GROWTH FACTOR;

ANIMAL CELL; ARTICLE; BRAIN MITOCHONDRION; CELL PROTECTION; CELL TRANSPLANTATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; GENETIC ENGINEERING; NERVE CELL DEGENERATION; NERVE FIBER TRANSECTION; NEUROTOXICITY; NEUROTROPISM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; FIBROBLASTS; GENETIC ENGINEERING; MALE; NERVE DEGENERATION; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE; SUBSTANTIA NIGRA; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA;

EID: 0028276809     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.91.11.5104     Document Type: Article

References (51)