Dopaminergic transplants in patients with Parkinson's disease: Neuroanatomical correlates of clinical recovery

Experimental Neurology

Volumn 144, Issue 1, 1997, Pages 41-46

  Kordower, Jeffrey H ^a   Goetz, Christopher G ^a   Freeman, Thomas B ^b   Olanow, C Warren ^c  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TYROSINE 3 MONOOXYGENASE;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LOCOMOTION; NERVE TRANSPLANTATION; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

EID: 0031106244     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1996.6386     Document Type: Article

References (44)

1. 1. BANKIEWICZ, K. S., R. J. PLUNKETT, I. J. KOPIN, D. M. JACOBOWITZ, W. T. LONDON, AND E. OLFIELD. 1988. Transient behavioral recovery in hemiparkinsonian primates after adrenal medullary allografts. Prog. Brain Res. 78: 543-550.
2. 2. BOHN, M. C., L. CULPIT, M. M. MARCIANO, AND D. M. GASH. 1987. Adrenal medullary grafts enhance recovery of striatal dopaminergic fibers. Science 237: 913-916.
3. 3. COLLIER, T. C., AND J. H. KORDOWER. 1994. Fetal nigral transplants for Parkinson's disease: Apreclinical and clinical prospectus. Pages 403-421 in W. C. Koller and G. Paulson, Eds., Therapeutic Approaches to Parkinson's Disease. Dekker, New York.
4. 4. DATE, I., S. ASARI, AND T. OHMOTO. 1995. Two year follow-up study of a parkinsonian patient with severe motor fluctuations treated by cografts of adrenal medulla and peripheral nerve into bilateral nerve into bilateral caudate nuclei. Neurosurgery 37: 515-519.
5. 5. FIANDACA, M. S., J. H. KORDOWER, S.-S. JIAO, J. T. HANSEN, M. F. D. NOTTER, AND D. M. GASH. 1988. Adrenal medullary autografts into the basal ganglia of Cebus monkeys: Injury-induced regeneration. Exp. Neurol. 102: 76-91.
6. 6. FOLKERTH, R. D., AND R. DURSO. 1996. Survival and proliferation of non-neural tissues with obstruction of cerebral ventricle in a parkinsonian patient treated with fetal allografts. Neurology 46: 1219-1225.
7. 7. FRANK, F., C. STURIALE, AND G. GAIST. 1988. Adrenal medulla autograft in a human brain for Parkinson's disease. Acta Neurochir. 94: 39.
8. 8. FREED, C. R., R. E. BREEZE, N. L. ROSENBERG, S. A. SCHNECK, E. KRIEK, J.-X. QI, T. LONE, Y.-B. ZHANG, J. SNYDER, T. WELLS, L. O. RAMIG, L. THOMPSON, J. C. MAZZIOTTA, S. HUANG, S. T. GRAFTON, D. BROOKS, G. SAWLE, G. SCHROTER, G., AND A. A. ANSARI. 1992. Survival of implanted fetal dopamine cells and neurological improvement 12 to 46 months after transplantation for Parkinson's disease. N. Engl. J. Med. 327: 1549.
9. 9. FREED, W. J., M. MORIHISA, H. E. SPOOR, B. J. HOFFER, L. OLSON, A. SEIGER, AND R. J. WYATT. 1981. Transplanted adrenal chromaffin cells in rat brain reduce lesion-induced rotational behavior. Nature 292: 351-352.
10. 10. FREED, W. J., F. KAROUM, H. E. SPOOR, L. OLSON, J. MORIHISA, AND R. J. WYATT. 1983. Catecholamine content of intracerebral adrenal medulla grafts. Brain Res. 269: 184-189.
11. 11. FREEMAN, T. B., C. W. OLANOW, R. A. HAUSER, G. M. NAUERT, D. A. SMITH, C. V. BORLONGAN, P. R. SANBERG, D. A. HOLT, J. H. KORDOWER, F. J. G. VINGERHOETS, B. J. SNOW, D. CALNE, AND L. GAUGER 1995. Bilateral fetal nigral transplantation into the post-commissural putamen as a treatment for Parkinson's disease: Six month follow-up. Ann. Neurol. 38: 379-388.
12. 12. FREEMAN, T. B., P. R. SANBERG, G. M. NAUERT, C. V. BORLONGAN, E.-Z. LIU, B. D. BOSS, D. SPECTOR, C. W. OLANOW, AND J. H. KORDOWER. 1995. The influence of donor age on the survival of solid and suspension intraparenchymal human embryonic nigral grafts. Cell Transplant. 4: 141-154.
13. 13. FREEMAN, T. B., M. S. SPENCE, B. D. BOSS, D. H. SPECTOR, R. E. STRECKER, C. W. OLANOW, AND J. H. KORDOWER. 1991. Development of dopaminergic neurons in the human substantia nigra. Exp. Neurol. 113: 344-353.
14. 14. FREEMAN, T. B., AND J. H. KORDOWER 1991. Human cadaver embryonic substantia nigra grafts: ontogeny, preoperative graft preparation and tissue storage. Pages 163-170. in O. Lindvall, A. Björklund, and H. Widner, Eds., Intracerebral Transplantation in Movement Disorders. Elsevier, Amsterdam.
15. 15. GOETZ, C. G., C. W. OLANOW, W. C. KOLLER, R. D. PENN, D. CAHILL, R. MORANTZ, G. STEBBINS, C. M. TANNER, H. L. KLAWANS, K. M. SHANNON, C. L. COMELLA, T. WITT, C. COX, M. WAXMAN, AND L. GAUGER. 1989. Multicenter study of autologous adrenal medullary transplantation to the corpus striatum in patients with advanced Parkinson's disease. N. Engl. J. Med. 320: 337-341.
16. 16. HANSEN, J. T., J. H. KORDOWER, M. S. FIANDACA, S.-S. JIAO, M. F. D. NOTTER, AND D. M. GASH. 1988. Adrenal medullary autografts into the basal ganglia of Cebus monkeys: graft viability and fine structure. Exp. Neurol. 102: 65-75.
17. 17. HERRERA-MARCHITZ, M., I. STROMBERG, D. OLSSON, U. UNGERSTEDT, AND L. OLSON. 1984. Adrenal medullary implants into the dopamine denervated rat striatum. II. Acute behavior as a function of graft amount and location and its modulation by neuroleptics. Brain Res. 297: 53-61.
18. 18. HIRSCH, E. C., C. DUYCKAERTS, F. JAVOY-AGID, J.-J. HAUW, AND Y. AGIO. 1990. Does adrenal graft enhance recovery of dopaminergic neurons in Parkinson's disease. Ann. Neurol. 27: 676-682.
19. 19. HITCHCOCK, E. H., H. L. WHITWELL, M. V. SOFRONIEW, AND K. S. BANKIEWICZ. 1994. Survival of TH-positive and neuromelanin-containing cells in patients with Parkinson's disease after intrastriatal grafting of fetal ventral mesencephalon. Exp. Neurol. 129: 3. [Abstract]
20. 20. HURTIG, H., J. JOYCE, J. R. SLADEK JR., AND J. Q. TROJANOWSKI. 1989. Post-mortem analysis of adrenal medulla-to-caudate autograft in a patient with Parkinson's disease. Ann. Neurol. 25: 607-614.
21. 21. KORDOWER, J. H., S. B. SCHUELER, D. BREDESEN, T. B. FREEMAN, AND J. SAGEN. 1994. Neural grafting for Parkinson's disease: An evaluation of dopaminergic donor tissues. Pages 17-37 in J. Marwah, H. Teitlebaum, and H. Prasad, Eds.), Neural Transplantation, CNS Neuronal Injury, and Regeneration: Recent Advances. CRC Press, Boca Raton FL.
22. 22. KORDOWER, J. H., E. COCHRAN, R. PENN, AND C. GOETZ. 1991. Putative chromaffin cell survival and enhanced host-derived TH-fiber innervation following a functional adrenal medulla autograft for Parkinson's disease. Ann. Neurol. 29: 565-572.
23. 23. KORDOWER, J. H., M. S. FIANDACA, M. F. D. NOTTER, J. T. HANSEN, AND D. M. GASH. 1990. NGF-like trophic support from peripheral nerve for grafted rhesus adrenal chromaffin cells. J. Neurosurg. 73: 418-428.
24. 24. KORDOWER, J. H., T. B. FREEMAN, B. J. SNOW, F. J. G. VINGER-HOETS, E. J. MUFSON, P. R. SANBERG, R. A. HAUSER, D. A. SMITH, G. M. NAUERT, D. P. PERL, AND C. W. OLANOW. 1995. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N. Engl. J. Med. 332: 1118-1124.
25. 25. KORDOWER, J. H., J. M. ROSENSTEIN, T. J. COLLIER, M. A. BURKE, E.-Y. CHEN, J. M. LI, L. MARTEL, A. E. LEVEY, E. J. MUFSON, T. B. FREEMAN, AND C. W. OLANOW. 1996. Functional fetal nigral grafts in a patient with Parkinson's disease: chemoanatomic, ultrastructural, and metabolic studies. J. Comp. Neurol., 370: 203-230.
26. 26. KORDOWER, J. H., D. L. FELTEN, AND D. M. GASH, 1992. Dopaminergic transplants for Parkinson's disease. Pages 175-224 in C. W. Olanow and A. Lieberman, Eds., Scientific Basis for Therapy in Parkinson's Disease. Parthenon Press, Lanes., England.
27. 27. KORDOWER, J. H., J. M. ROSENSTEIN, T. J. COLLIER, E.-Y. CHEN, J. M. LI, A. E. LEVEY, E. J. MUFSON, P. R. SANBERG, T. B. FREEMAN, C. W. OLANOW. 1996. Functional fetal nigral grafts in two patients with Parkinson's disease. Am. Soc. Neural Transplantation 3: 5. [Abstract]
28. 28. LINDVALL, O., E. O. BACKLUND, L. FARDE, G. SEDVALL, R. FREEDMAN, AND B. J. HOFFER 1987. Transplantation in Parkinson's disease: Two cases of adrenal medullary grafts to the putamen. Ann. Neurol. 22: 457-468.
29. 29. LINDVALL, O., P. BRUNDIN, H. WIDNER, S. REHNCRONA, B. GUSTAVII, R. FRACKOWIAK, K. L. LEENDERS, G. SAWLE, J. C. ROTHWELL, C. D. MARSDEN, AND A. BJÖRKLUND. 1990. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 247: 574-577.
30. 30. LINDVALL, O., G. SAWLE, H. WIDNER, J. C. ROTHWELL, A. BJORKLUND, D. BROOKS, P. BRUNDIN, R. FRACKOWIAK, C. D. MARSDEN, AND P. ODIN. 1994. Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann. Neurol. 35: 172-180.
31. 31. MADRAZO, I., T. DRUCKER-COLÍN, V. DAÍZ, J. MARTINEZ-MATA, C. TORRES, AND J. J. BECERREL. 1987. Open microsurgical autorgraft of adrenal medulla to the right caudate nucleus in two patients with intractable Parkinson's disease. N. Engl. J. Med. 316: 831-833.
32. 32. MORIHISA, J. M., R. K. NAKAMURA, W. J. FREED, M. MISHKIN, AND R. J. WYATT. 1984. Adrenal medulla grafts survive and exhibit catecholamine-specific fluorescence in the primate brain. Exp. Neurol. 84: 643-653.
33. 33. OLANOW, C. W., W. C. KOLLER, C. G. GOETZ, G. T. STEBBINS, D. W. CAHILL, L. L. GAUGER, R. MORANTZ, R. D. PENN, C. M. TANNER, AND H. L. KLAWANS. 1990. Autologous transplantation of adrenal medulla in Parkinson's disease. 18-month results. Arch. Neurol. 47: 1286-1289.
34. 34. OLANOW, C. W., J. H. KORDOWER, AND T. B. FREEMAN. 1996. Fetal nigral transplantation for the treatment of Parkinson's disease. Trends Neurosci. 19: 102-108.
35. 35. PESCHANSKI, M., G. DEFER, J. P. N'GUYEN, F. RICOLFI, J. C. MONFORT, P. REMY, C. GENY, Y. SAMSON, P. HANTRAYE, AND R. JENY. 1994. Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon. Brain 117: 487-499.
36. 36. PETERSON, D. I., M. LYNNE PRICE, AND C. S. SMALL. 1989. Autopsy findings in a patient who had adrenal to brain transplant for Parkinson's disease. Neurology 39: 235-238.
37. 37. REDMOND JR., D. E., C. LERANTH, D. D. SPENCER, R. ROBBINS, T. VOLLMER, J. H. KIM, R. H. ROTH, A. J. DWORK, AND F. NAFTOLIN. 1990. Fetal graft survival. Lancet 336: 820-821.
38. 38. SCHUELER, S. B., J. SAGEN, G. D. PAPPAS, AND J. H. KORDOWER 1995. Long-term viability of isolated bovine adrenal chromaffin cells following intrastriatal transplantation. Cell Transplant. 4: 55-64.
39. 39. SPENCER, D. D., R. J. ROBBINS, F. NAFTOLIN, K. L. MAREK, T. VOLLMER, C. LERANTH, R. H. ROTH, L. H. PRICE, A. GJEDDE, B. BUNNEY, K. J. SASS, J. D. ELSWORTH, E. L. KIER, R. MAKUCH, P. HOFFER, AND D. E. REDMOND, JR. 1992. Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson's disease. N. Engl. J. Med. 327: 1541-1543.
40. 40. STROMBERG, I., M. HERRERA-MARCHITZ, L. HULTGREN, U. UNGERSTEDT, AND L. OLSON. 1984. Adrenal medullary implants into the dopamine denervated rat striatum. I. Acute catecholamine levels in grafts and gost caudate as determined by HPLC-electrochemistry and fluorescence histochemical image analysis. Brain Res. 297: 41-51.
41. 41. STRÖMBERG, I., M. HERRERA-MARSCHITZ, U. UNGERSTEDT, T. EBENDAL, AND L. OLSON. 1985. Chronic implants of chomaffin tissue into the dopamine-denervated striatum: Effects of NGF on graft survival, fiber growth and rotational behavior. Exp. Brain Res. 60: 335-349.
42. 42. WATERS, C., H. H. ITABASHI, M. L. J. APUZZO, AND L. P. WEINER 1990. Adrenal to caudate transplantation-Apostmortem study. Movement Disorders 5: 248-250.
43. 43. WATTS, R. L., A. MANDIR, AND R. A. E. BAKAY. 1995. Intrastriatal cografts of autologous adrenal medulla and sural nerve in MPTP-induced parkinsonian macaques: Behavioral and anatomical assessment. Cell Transplant. 4: 27-38.
44. 44. WATTS, R. L., A. FREEMAN, C. G. GOETZ, S. GRAHAM, G. O. ZAKERS, R. A. E. BAKAY, G. T. STEBBINS, AND R. D. PENN. 1993. Autologous intrastriatal adrenal medulla/nerve cografts in Parkinson's disease: Early results. Neurology A222.