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Volumn 10, Issue , 2002, Pages 127-145

Chapter 7 Altered T-lymphocyte calcium signaling and age-related disease

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EID: 0038728198     PISSN: 15663124     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s1566-3124(02)10019-8     Document Type: Review
Times cited : (2)

References (92)
  • 1
    • 0033787565 scopus 로고    scopus 로고
    • Ageing of lymphocytes and lymphocytes in the aged
    • A. Globerson R.B. Effros Ageing of lymphocytes and lymphocytes in the aged Immunol. Today 21 2000 515 521
    • (2000) Immunol. Today , vol.21 , pp. 515-521
    • Globerson, A.1    Effros, R.B.2
  • 3
    • 0023640683 scopus 로고
    • Age-related changes of splenic T cells in mice-a flow cytometric analysis
    • M. Utsuyama K. Hirokawa Age-related changes of splenic T cells in mice-a flow cytometric analysis Mech. Ageing. Dev. 40 1987 89 102
    • (1987) Mech. Ageing. Dev. , vol.40 , pp. 89-102
    • Utsuyama, M.1    Hirokawa, K.2
  • 6
    • 0031464631 scopus 로고    scopus 로고
    • Genes, immunity, and senescence: looking for a link
    • G. Doria D. Frasca Genes, immunity, and senescence: looking for a link Immunol. Rev. 160 1997 159 170
    • (1997) Immunol. Rev. , vol.160 , pp. 159-170
    • Doria, G.1    Frasca, D.2
  • 7
    • 0028277806 scopus 로고
    • Extrusion of the P glycoprotein substrate rhodamine-123 distinguishes CD4 memory T cell subsets that differ in IL-2-driven IL-4 production
    • J.M. Witkowski S.P. Li G. Gorgas R.A. Miller Extrusion of the P glycoprotein substrate rhodamine-123 distinguishes CD4 memory T cell subsets that differ in IL-2-driven IL-4 production J. Immunol. 153 1994 658 665
    • (1994) J. Immunol. , vol.153 , pp. 658-665
    • Witkowski, J.M.1    Li, S.P.2    Gorgas, G.3    Miller, R.A.4
  • 8
    • 0030999692 scopus 로고    scopus 로고
    • Cytokine production by subsets of CD4 memory T cells differing in P-glycoprotein expression: effects of aging
    • N. Bining R.A. Miller Cytokine production by subsets of CD4 memory T cells differing in P -glycoprotein expression: effects of aging J. Gerontol. A Biol. Sci. Med. Sci. 52 1997 B137 B145
    • (1997) J. Gerontol. A Biol. Sci. Med. Sci. , vol.52 , pp. B137-B145
    • Bining, N.1    Miller, R.A.2
  • 9
    • 0033105808 scopus 로고    scopus 로고
    • Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P-glycoprotein
    • J.M. Witkowski R.A. Miller Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P -glycoprotein Mech. Ageing Dev. 107 1999 165 180
    • (1999) Mech. Ageing Dev. , vol.107 , pp. 165-180
    • Witkowski, J.M.1    Miller, R.A.2
  • 10
    • 0030913726 scopus 로고    scopus 로고
    • Evidence of enhanced type 2 response and impaired upregulation of type 1 response in frail elderly nursing home residents
    • S. Castle K. Uyemura W. Wong R. Modlin R. Effros Evidence of enhanced type 2 response and impaired upregulation of type 1 response in frail elderly nursing home residents Mech. Ageing Dev. 94 1997 7 16
    • (1997) Mech. Ageing Dev. , vol.94 , pp. 7-16
    • Castle, S.1    Uyemura, K.2    Wong, W.3    Modlin, R.4    Effros, R.5
  • 11
    • 0029918498 scopus 로고    scopus 로고
    • Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice
    • X. Yang J. Stedra J. Cerny Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice J. Exp. Med. 183 1996 959 970
    • (1996) J. Exp. Med. , vol.183 , pp. 959-970
    • Yang, X.1    Stedra, J.2    Cerny, J.3
  • 12
    • 0028929973 scopus 로고
    • A signalling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death
    • G.F. Weber S. Abromson-Leeman H. Cantor A signalling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death Immunity 2 1995 363 372
    • (1995) Immunity , vol.2 , pp. 363-372
    • Weber, G.F.1    Abromson-Leeman, S.2    Cantor, H.3
  • 13
    • 0026547056 scopus 로고
    • Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon
    • F. Letourneur R.D. Klausner Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon Science 255 1992 79 82
    • (1992) Science , vol.255 , pp. 79-82
    • Letourneur, F.1    Klausner, R.D.2
  • 14
    • 0028197215 scopus 로고
    • Phosphatidylinositol synthesis is a proximal event in intracellular signaling coupled to T cell receptor ligation
    • G.F. Weber H. Cantor Phosphatidylinositol synthesis is a proximal event in intracellular signaling coupled to T cell receptor ligation J. Immunol. 152 1994 4433 4443
    • (1994) J. Immunol. , vol.152 , pp. 4433-4443
    • Weber, G.F.1    Cantor, H.2
  • 15
    • 0031432911 scopus 로고    scopus 로고
    • Localization and treatment of an oxidation-sensitive defect within the TCR-coupled signalling pathway that is associated with normal and premature immunologic aging
    • G.F. Weber N.M. Mirza E.J. Yunis D. Dubey H. Cantor Localization and treatment of an oxidation-sensitive defect within the TCR-coupled signalling pathway that is associated with normal and premature immunologic aging Growth, Dev. Aging 61 1997 191 207
    • (1997) Growth, Dev. Aging , vol.61 , pp. 191-207
    • Weber, G.F.1    Mirza, N.M.2    Yunis, E.J.3    Dubey, D.4    Cantor, H.5
  • 16
    • 0031739674 scopus 로고    scopus 로고
    • Activation of T cells by superantigen: cytokine production but not apoptosis depends on MEK-1 activity
    • B. Adler G.F. Weber H. Cantor Activation of T cells by superantigen: cytokine production but not apoptosis depends on MEK-1 activity Eur. J. Immunol. 28 1998 3749 3754
    • (1998) Eur. J. Immunol. , vol.28 , pp. 3749-3754
    • Adler, B.1    Weber, G.F.2    Cantor, H.3
  • 17
    • 0035946844 scopus 로고    scopus 로고
    • Costimulation through adhesion molecules determines the response to ligation of the T-cell antigen receptor
    • B. Adler S. Ashkar H. Cantor G.F. Weber Costimulation through adhesion molecules determines the response to ligation of the T-cell antigen receptor Cell. Immunol. 210 2001 30 40
    • (2001) Cell. Immunol. , vol.210 , pp. 30-40
    • Adler, B.1    Ashkar, S.2    Cantor, H.3    Weber, G.F.4
  • 18
    • 0032168702 scopus 로고    scopus 로고
    • Protein kinase C regulates Fas (CD95/APO-1) expression
    • R. Wang L. Zhang D. Yin R.A. Mufson Y. Shi Protein kinase C regulates Fas (CD95/APO-1) expression J. Immunol. 161 1998 2201 2207
    • (1998) J. Immunol. , vol.161 , pp. 2201-2207
    • Wang, R.1    Zhang, L.2    Yin, D.3    Mufson, R.A.4    Shi, Y.5
  • 19
    • 0023549916 scopus 로고
    • Evidence that guanine-nucleotide binding regulatory proteins couple cell-surface receptors to the breakdown of inositol-containing lipids during T-lymphocyte mitogenesis
    • A.R. Mire-Sluis A.V. Hoffbrand R.G. Wickremasinghe Evidence that guanine-nucleotide binding regulatory proteins couple cell-surface receptors to the breakdown of inositol-containing lipids during T-lymphocyte mitogenesis Biochem. Biophys. Res. Commun. 148 1987 1223 1231
    • (1987) Biochem. Biophys. Res. Commun. , vol.148 , pp. 1223-1231
    • Mire-Sluis, A.R.1    Hoffbrand, A.V.2    Wickremasinghe, R.G.3
  • 20
    • 0026009863 scopus 로고
    • A 32-kD GTP-binding protein associated with the CD4-p561ck and CD8-p561ck T cell receptor complexes
    • J.C. Telfer C.E. Rudd A 32-kD GTP-binding protein associated with the CD4-p561ck and CD8-p561ck T cell receptor complexes Science 254 1991 439 441
    • (1991) Science , vol.254 , pp. 439-441
    • Telfer, J.C.1    Rudd, C.E.2
  • 21
    • 0023199559 scopus 로고
    • Diminished calcium influx in lectin-stimulated T cells from old mice
    • R.A. Miller B. Jacobson G. Weil E.R. Simons Diminished calcium influx in lectin-stimulated T cells from old mice J. Cell Physiol. 132 1987 337 342
    • (1987) J. Cell Physiol. , vol.132 , pp. 337-342
    • Miller, R.A.1    Jacobson, B.2    Weil, G.3    Simons, E.R.4
  • 22
    • 0023200924 scopus 로고
    • Age-related defect in signal transduction during lectin activation of murine T lymphocytes
    • J.J. Proust C.R. Filburn S.A. Harrison M.A. Buchholz A.A. Nordin Age-related defect in signal transduction during lectin activation of murine T lymphocytes J. Immunol. 139 1987 1472 1478
    • (1987) J. Immunol. , vol.139 , pp. 1472-1478
    • Proust, J.J.1    Filburn, C.R.2    Harrison, S.A.3    Buchholz, M.A.4    Nordin, A.A.5
  • 23
    • 0025346495 scopus 로고
    • Diminished calcium signal generation in subsets of T lymphocytes that predominate in old mice
    • B. Philosophe R.A. Miller Diminished calcium signal generation in subsets of T lymphocytes that predominate in old mice J. Gerontol. 45 1990 B87 B93
    • (1990) J. Gerontol. , vol.45 , pp. B87-B93
    • Philosophe, B.1    Miller, R.A.2
  • 24
    • 0028922867 scopus 로고
    • Phospholipid metabolism of lymphocytes with inhibited glutathione synthesis using l-buthionine-S,R-sulfoximine
    • G.P. Palace D.A. Lawrence Phospholipid metabolism of lymphocytes with inhibited glutathione synthesis using l -buthionine- S,R -sulfoximine Free Radic. Biol. Med. 18 1995 709 720
    • (1995) Free Radic. Biol. Med. , vol.18 , pp. 709-720
    • Palace, G.P.1    Lawrence, D.A.2
  • 25
    • 0026586145 scopus 로고
    • Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase C gamma 1
    • S.B. Kanner T.J. Kavanagh A. Grossmann S.L. Hu J.B. Bolen P.S. Rabinovitch J.A. Ledbetter Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase C gamma 1 Proc. Natl. Acad. Sci. USA 89 1992 300 304
    • (1992) , pp. 300-304
    • Kanner, S.B.1    Kavanagh, T.J.2    Grossmann, A.3    Hu, S.L.4    Bolen, J.B.5    Rabinovitch, P.S.6    Ledbetter, J.A.7
  • 29
    • 0029117434 scopus 로고
    • Ligation of the T-cell antigen receptor (TCR) induces association of hSosl, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR
    • A.E. Nel S. Gupta L. Lee J.A. Ledbetter S.B. Kanner Ligation of the T-cell antigen receptor (TCR) induces association of hSosl, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR J. Biol. Chem. 270 1995 18428 18436
    • (1995) J. Biol. Chem. , vol.270 , pp. 18428-18436
    • Nel, A.E.1    Gupta, S.2    Lee, L.3    Ledbetter, J.A.4    Kanner, S.B.5
  • 30
    • 0028180585 scopus 로고
    • GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation
    • M. Sieh A. Batzer J. Schlessinger A. Weiss GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation Mol. Cell. Biol. 14 1994 4435 4442
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4435-4442
    • Sieh, M.1    Batzer, A.2    Schlessinger, J.3    Weiss, A.4
  • 31
    • 0032531124 scopus 로고    scopus 로고
    • Phosphorylation and coupling of ζ-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans
    • R.L. Whisler C.I. Karanfilov Y.G. Newhouse C.C. Fox R.R. Lakshmanan B. Liu Phosphorylation and coupling of ζ-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans Mech. Ageing Dev. 105 1998 115 135
    • (1998) Mech. Ageing Dev. , vol.105 , pp. 115-135
    • Whisler, R.L.1    Karanfilov, C.I.2    Newhouse, Y.G.3    Fox, C.C.4    Lakshmanan, R.R.5    Liu, B.6
  • 32
    • 0032883594 scopus 로고    scopus 로고
    • Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylations of ζ-chains and p59fyn/p561ck in human T cells
    • R.L. Whisler M. Chen B. Liu Y.G. Newhouse Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylations of ζ-chains and p59fyn/p561ck in human T cells Mech. Ageing Dev. 111 1999 49 66
    • (1999) Mech. Ageing Dev. , vol.111 , pp. 49-66
    • Whisler, R.L.1    Chen, M.2    Liu, B.3    Newhouse, Y.G.4
  • 33
    • 0032143881 scopus 로고    scopus 로고
    • Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets: down-regulation of tyrosine phosphorylation of ZAP-70
    • B. Chakravarti D.N. Chakravrti J. Devecis B. Seshi G.N. Abraham Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets: down-regulation of tyrosine phosphorylation of ZAP-70 Mech. Ageing Dev. 194 1998 41 58
    • (1998) Mech. Ageing Dev. , vol.194 , pp. 41-58
    • Chakravarti, B.1    Chakravrti, D.N.2    Devecis, J.3    Seshi, B.4    Abraham, G.N.5
  • 35
    • 0032535239 scopus 로고    scopus 로고
    • Increased ZAP-70 association with CD3χ in CD4 T cells from old mice
    • G.G. Garcia R.A. Miller Increased ZAP-70 association with CD3χ in CD4 T cells from old mice Cell. Immunol. 190 1998 91 100
    • (1998) Cell. Immunol. , vol.190 , pp. 91-100
    • Garcia, G.G.1    Miller, R.A.2
  • 36
    • 0031561783 scopus 로고    scopus 로고
    • Differential tyrosine phosphorylation of χ-chain dimmers in mouse CD4 T lymphocytes: effect of age
    • G.G. Garcia R.A. Miller Differential tyrosine phosphorylation of χ-chain dimmers in mouse CD4 T lymphocytes: effect of age Cell. Immunol. 175 1997 51 57
    • (1997) Cell. Immunol. , vol.175 , pp. 51-57
    • Garcia, G.G.1    Miller, R.A.2
  • 38
    • 0030800053 scopus 로고    scopus 로고
    • Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T cells from elderly humans stimulated through the T cell receptor (TCR)/CD3 complex
    • R.L. Whisler S.E. Bagenstose Y.G. Newhouse K.W. Carle Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T cells from elderly humans stimulated through the T cell receptor (TCR)/CD3 complex Mech. Ageing Dev. 98 1997 57 73
    • (1997) Mech. Ageing Dev. , vol.98 , pp. 57-73
    • Whisler, R.L.1    Bagenstose, S.E.2    Newhouse, Y.G.3    Carle, K.W.4
  • 39
    • 0032502361 scopus 로고    scopus 로고
    • Activation of p21ras/MAPK signal transduction molecules decreases with age in mitogen-stimulated T cells from rats
    • M.A. Pahlavani M.D. Harris A. Richardson Activation of p21ras/MAPK signal transduction molecules decreases with age in mitogen-stimulated T cells from rats Cell. Immunol. 185 1998 39 48
    • (1998) Cell. Immunol. , vol.185 , pp. 39-48
    • Pahlavani, M.A.1    Harris, M.D.2    Richardson, A.3
  • 40
    • 0032525352 scopus 로고    scopus 로고
    • Decreased association of p561Ck with CD4 may account for lowered tyrosine kinase activity in mitogen-activated human T lymphocytes during aging
    • 1Ck with CD4 may account for lowered tyrosine kinase activity in mitogen-activated human T lymphocytes during aging Cell. Immunol. 186 1998 154 160
    • (1998) Cell. Immunol. , vol.186 , pp. 154-160
    • Tinkle, C.W.1    Lipshitz, D.2    Ponnappan, U.3
  • 41
    • 0018192539 scopus 로고
    • Cyclic nucleotide levels in resting and mitogen-stimulated spleen cell suspensions from young and old mice
    • C.F. Tam R.L. Walford Cyclic nucleotide levels in resting and mitogen-stimulated spleen cell suspensions from young and old mice Mech. Ageing Dev. 7 1978 309 320
    • (1978) Mech. Ageing Dev. , vol.7 , pp. 309-320
    • Tam, C.F.1    Walford, R.L.2
  • 42
    • 0015782110 scopus 로고
    • Promotion of replication in lymphoid cells by specific thiols and disulfides in vitro
    • J.D. Broome M.W. Jeng Promotion of replication in lymphoid cells by specific thiols and disulfides in vitro Effects on mouse lymphoma cells in comparison with splenic lymphocytes J. Exp. Med. 138 1973 574 592
    • (1973) , pp. 574-592
    • Broome, J.D.1    Jeng, M.W.2
  • 43
    • 0027268223 scopus 로고
    • Thiol reagents increase the affinity of the inositol 1,4,5-trisphosphate receptor
    • M. Hilly F. Pietri-Rouxel J.F. Coquil M. Guy J.P. Mauger Thiol reagents increase the affinity of the inositol 1,4,5-trisphosphate receptor J. Biol. Chem. 268 1993 16488 16494
    • (1993) J. Biol. Chem. , vol.268 , pp. 16488-16494
    • Hilly, M.1    Pietri-Rouxel, F.2    Coquil, J.F.3    Guy, M.4    Mauger, J.P.5
  • 44
    • 0025681755 scopus 로고
    • Life span profiles of glutathione and acetaminophen detoxification
    • T.S. Chen J.P. Richie Jr. C.A. Lang Life span profiles of glutathione and acetaminophen detoxification Drug Metab. Dispos. 18 1990 882 887
    • (1990) Drug Metab. Dispos. , vol.18 , pp. 882-887
    • Chen, T.S.1    Richie, J.P.2    Lang, C.A.3
  • 45
    • 0034100421 scopus 로고    scopus 로고
    • Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes
    • K.J. Lenton H. Therriault A.M. Cantin T. Fueloep H. Payette J.R. Wagner Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes Am. J. Clin. Nutr. 71 2000 1194 1200
    • (2000) Am. J. Clin. Nutr. , vol.71 , pp. 1194-1200
    • Lenton, K.J.1    Therriault, H.2    Cantin, A.M.3    Fueloep, T.4    Payette, H.5    Wagner, J.R.6
  • 46
    • 0024461561 scopus 로고
    • Differential lymphocyte growth-modifying effects of oxidants: changes in cytosolic Ca2+
    • D.D. Duncan D.A. Lawrence Differential lymphocyte growth-modifying effects of oxidants: changes in cytosolic Ca2+ Toxicol. Appl. Pharmacol. 100 1989 485 497
    • (1989) Toxicol. Appl. Pharmacol. , vol.100 , pp. 485-497
    • Duncan, D.D.1    Lawrence, D.A.2
  • 48
    • 0029988530 scopus 로고    scopus 로고
    • Age-related reductions in the activation of mitogen-activated protein kinase p44mapk/ERK1 and p42mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complexes
    • mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complexes Cell. Immunol. 168 1996 201 210
    • (1996) Cell. Immunol. , vol.168 , pp. 201-210
    • Whisler, R.L.1    Newhouse, Y.G.2    Bagenstose, S.E.3
  • 49
    • 0031573895 scopus 로고    scopus 로고
    • Reductions in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly humans stimulated by the TCR/CD3 complex and costimulatory signals
    • B. Liu K.W. Carle R.L. Whisler Reductions in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly humans stimulated by the TCR/CD3 complex and costimulatory signals Cell. Immunol. 182 1997 79 88
    • (1997) Cell. Immunol. , vol.182 , pp. 79-88
    • Liu, B.1    Carle, K.W.2    Whisler, R.L.3
  • 50
    • 0033228191 scopus 로고    scopus 로고
    • Age-sensitive and -insensitive pathways leading to JNK activation in mouse CD4+ T-cells
    • + T-cells Cell. Immunol. 197 1999 83 90
    • (1999) Cell. Immunol. , vol.197 , pp. 83-90
    • Kirk, C.J.1    Miller, R.A.2
  • 51
    • 0030605949 scopus 로고    scopus 로고
    • The effect of age on the expression of Interleukin-2
    • M.A. Pahlavani A. Richardson The effect of age on the expression of Interleukin-2 Mech. Ageing Dev. 89 1996 125 154
    • (1996) Mech. Ageing Dev. , vol.89 , pp. 125-154
    • Pahlavani, M.A.1    Richardson, A.2
  • 52
    • 0022574519 scopus 로고
    • The effect of aging on the expression of interleukin 2 messenger ribonucleic acid
    • W.T. Wu M.A. Pahlavani H.T. Cheung A. Richardson The effect of aging on the expression of interleukin 2 messenger ribonucleic acid Cell. Immunol. 100 1986 224 231
    • (1986) Cell. Immunol. , vol.100 , pp. 224-231
    • Wu, W.T.1    Pahlavani, M.A.2    Cheung, H.T.3    Richardson, A.4
  • 53
    • 0029148817 scopus 로고
    • The age-related decline in the induction of IL-2 transcription is correlated to changes in the transcription factor NFAT
    • M.A. Pahlavani M.D. Harris A. Richardson The age-related decline in the induction of IL-2 transcription is correlated to changes in the transcription factor NFAT Cell. Immunol. 165 1995 84 91
    • (1995) Cell. Immunol. , vol.165 , pp. 84-91
    • Pahlavani, M.A.1    Harris, M.D.2    Richardson, A.3
  • 54
    • 0032704885 scopus 로고    scopus 로고
    • Age-related decline in activation of calcium/calmodulin-dependent phosphatase calcineurin and kinase CaMK-IV in rat T cells
    • M.A. Pahlavani D.M. Vargas Age-related decline in activation of calcium/calmodulin-dependent phosphatase calcineurin and kinase CaMK-IV in rat T cells Mech. Ageing Dev. 112 1999 59 74
    • (1999) Mech. Ageing Dev. , vol.112 , pp. 59-74
    • Pahlavani, M.A.1    Vargas, D.M.2
  • 55
    • 0026452286 scopus 로고
    • Loss of transcription factor AP-1 DNA binding activity during lymphocyte aging in vivo
    • E. Sikora B. Kaminska E. Radziszewska L. Kaczmarek Loss of transcription factor AP-1 DNA binding activity during lymphocyte aging in vivo FEBS Lett. 312 1992 179 182
    • (1992) FEBS Lett. , vol.312 , pp. 179-182
    • Sikora, E.1    Kaminska, B.2    Radziszewska, E.3    Kaczmarek, L.4
  • 56
    • 0027484040 scopus 로고
    • Reduced activation of transcriptional factor AP-1 among peripheral blood T cells from elderly humans after PHA stimulation: restorative effect of phorbol diesters
    • R.L. Whisler B. Liu L.C. Wu M. Chen Reduced activation of transcriptional factor AP-1 among peripheral blood T cells from elderly humans after PHA stimulation: restorative effect of phorbol diesters Cell. Immunol. 152 1993 96 109
    • (1993) Cell. Immunol. , vol.152 , pp. 96-109
    • Whisler, R.L.1    Liu, B.2    Wu, L.C.3    Chen, M.4
  • 58
    • 0029743992 scopus 로고    scopus 로고
    • The age-related changes in DNA binding activity of AP-1, NF-κB and Oct-1 transcription factors in lymphocytes from old rats
    • M.A. Pahlavani M.D. Harris The age-related changes in DNA binding activity of AP-1, NF-κB and Oct-1 transcription factors in lymphocytes from old rats Age 19 1996 45 54
    • (1996) Age , vol.19 , pp. 45-54
    • Pahlavani, M.A.1    Harris, M.D.2
  • 59
    • 0031561762 scopus 로고    scopus 로고
    • Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging
    • R.L. Whisler M. Chen L. Beiqing K.W. Carle Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging Cell. Immunol. 175 1997 41 50
    • (1997) Cell. Immunol. , vol.175 , pp. 41-50
    • Whisler, R.L.1    Chen, M.2    Beiqing, L.3    Carle, K.W.4
  • 60
    • 0033558925 scopus 로고    scopus 로고
    • Decreased proteasome-mediated degradation in T cells from the elderly: a role in immune senescence
    • U. Ponnappan M. Zhong G.U. Trebilcock Decreased proteasome-mediated degradation in T cells from the elderly: a role in immune senescence Cell. Immunol. 192 1999 167 174
    • (1999) Cell. Immunol. , vol.192 , pp. 167-174
    • Ponnappan, U.1    Zhong, M.2    Trebilcock, G.U.3
  • 61
    • 0030914988 scopus 로고    scopus 로고
    • Altered expression of various receptors on T-cells in young and old mice after activation
    • A. Wakikawa M. Utsuyama K. Hirokawa Altered expression of various receptors on T-cells in young and old mice after activation A flow cytometric analysis Mech. Aging Dev. 94 1997 113 122
    • (1997) , pp. 113-122
    • Wakikawa, A.1    Utsuyama, M.2    Hirokawa, K.3
  • 62
    • 0032478816 scopus 로고    scopus 로고
    • Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity
    • A.N. Vallejo A.R. Nestel M. Schirmer C.M. Weyand J.J. Goronzy Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity J. Biol. Chem. 273 1998 8119 8129
    • (1998) J. Biol. Chem. , vol.273 , pp. 8119-8129
    • Vallejo, A.N.1    Nestel, A.R.2    Schirmer, M.3    Weyand, C.M.4    Goronzy, J.J.5
  • 63
    • 0028201870 scopus 로고
    • Aged T cells are hyporesponsive to costimulation mediated by CD28
    • C.R. Engwerda B.S. Handweger B.S. Fox Aged T cells are hyporesponsive to costimulation mediated by CD28 J. Immunol. 152 1994 3740 3747
    • (1994) J. Immunol. , vol.152 , pp. 3740-3747
    • Engwerda, C.R.1    Handweger, B.S.2    Fox, B.S.3
  • 64
    • 0029940382 scopus 로고    scopus 로고
    • An age-related decrease in rescue from T cell death following costimulation mediated CD28
    • C.R. Engwerda B.S. Handweger B.S. Foxs An age-related decrease in rescue from T cell death following costimulation mediated CD28 Cell. Immunol. 25 1996 141 148
    • (1996) Cell. Immunol. , vol.25 , pp. 141-148
    • Engwerda, C.R.1    Handweger, B.S.2    Foxs, B.S.3
  • 67
    • 0028641601 scopus 로고
    • Association of insulin receptor substrate-1 with integrins
    • K. Vuori E. Ruoslahti Association of insulin receptor substrate-1 with integrins Science 266 1994 1576 1578
    • (1994) Science , vol.266 , pp. 1576-1578
    • Vuori, K.1    Ruoslahti, E.2
  • 68
    • 0030453194 scopus 로고    scopus 로고
    • Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors
    • S. Miyamoto H. Teramoto J.S. Gutkind K.M. Yamada Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors J. Cell Biol. 135 1996 1633 1642
    • (1996) J. Cell Biol. , vol.135 , pp. 1633-1642
    • Miyamoto, S.1    Teramoto, H.2    Gutkind, J.S.3    Yamada, K.M.4
  • 69
    • 0031003237 scopus 로고    scopus 로고
    • Cell anchorage permits efficient signal transduction between ras and its downstream kinases
    • T.H. Lin Q. Chen A. Howe R.L. Juliano Cell anchorage permits efficient signal transduction between ras and its downstream kinases J. Biol. Chem. 272 1997 8849 8852
    • (1997) J. Biol. Chem. , vol.272 , pp. 8849-8852
    • Lin, T.H.1    Chen, Q.2    Howe, A.3    Juliano, R.L.4
  • 70
    • 0033555820 scopus 로고    scopus 로고
    • Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro
    • A.W. O'Regan G.L. Chupp J.A. Lowry M. Goetschkes N. Mulligan J.S. Berman Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro J. Immunol. 162 1999 1024 1031
    • (1999) J. Immunol. , vol.162 , pp. 1024-1031
    • O'Regan, A.W.1    Chupp, G.L.2    Lowry, J.A.3    Goetschkes, M.4    Mulligan, N.5    Berman, J.S.6
  • 71
    • 0028970718 scopus 로고
    • Beta 1 integrins signal lipid second messengers required during cell adhesion
    • K.L. Auer B.S. Jacobson Beta 1 integrins signal lipid second messengers required during cell adhesion Mol. Biol. Cell 6 1995 1305 1313
    • (1995) Mol. Biol. Cell , vol.6 , pp. 1305-1313
    • Auer, K.L.1    Jacobson, B.S.2
  • 72
    • 17544364168 scopus 로고    scopus 로고
    • Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization
    • E.A. Clark R.O. Hynes Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization J. Biol. Chem. 271 1996 14814 14818
    • (1996) J. Biol. Chem. , vol.271 , pp. 14814-14818
    • Clark, E.A.1    Hynes, R.O.2
  • 73
    • 0024365697 scopus 로고
    • Immunohistochemical demonstration of age-related deposition of vitronectin (S-protein of complement) and terminal complement complex on dermal elastic fibers
    • K. Dahlback H. Lofberg J. Alumets B. Dahlback Immunohistochemical demonstration of age-related deposition of vitronectin (S-protein of complement) and terminal complement complex on dermal elastic fibers J. Invest. Dermatol. 92 5 1989 727 733
    • (1989) J. Invest. Dermatol. , vol.92 , Issue.5 , pp. 727-733
    • Dahlback, K.1    Lofberg, H.2    Alumets, J.3    Dahlback, B.4
  • 75
    • 0027143673 scopus 로고
    • Quantitative analysis of lymphocyte CD11a using standardized flow cytometry
    • M. Pallis A. Robins R. Powell Quantitative analysis of lymphocyte CD11a using standardized flow cytometry Scand. J. Immunol. 38 1993 559 564
    • (1993) Scand. J. Immunol. , vol.38 , pp. 559-564
    • Pallis, M.1    Robins, A.2    Powell, R.3
  • 77
    • 0028832492 scopus 로고
    • Diminished cell-cell binding by lymphocytes from healthy, elderly humans: evidence for altered activation of LFA-1 function with age
    • D.R. Jackola H.M. Hallgren Diminished cell-cell binding by lymphocytes from healthy, elderly humans: evidence for altered activation of LFA-1 function with age J. Gerontol. A Biol. Sci. Med. Sci. 50 1995 B368 B377
    • (1995) J. Gerontol. A Biol. Sci. Med. Sci. , vol.50 , pp. B368-B377
    • Jackola, D.R.1    Hallgren, H.M.2
  • 78
    • 0021365948 scopus 로고
    • Age-associated decline in precursor frequency for different T cell-mediated reactions, with preservation of helper or cytotoxic effect per precursor cells
    • R.A. Miller Age-associated decline in precursor frequency for different T cell-mediated reactions, with preservation of helper or cytotoxic effect per precursor cells J. Immunol. 132 1984 63 68
    • (1984) J. Immunol. , vol.132 , pp. 63-68
    • Miller, R.A.1
  • 80
    • 0017717237 scopus 로고
    • Free radical theory of aging: effect of free-radical-reaction inhibitors on the immune response
    • D. Harman M.L. Heidrick D.E. Eddy Free radical theory of aging: effect of free-radical-reaction inhibitors on the immune response J. Am. Geriatr. Soc. 25 1977 400 407
    • (1977) J. Am. Geriatr. Soc. , vol.25 , pp. 400-407
    • Harman, D.1    Heidrick, M.L.2    Eddy, D.E.3
  • 83
    • 0029837679 scopus 로고    scopus 로고
    • Spectrum of somatic mutation at the hypoxanthine phosphoribosyltransferase (hprt) gene of healthy people
    • K.J. Burkhart-Schultz C.L. Thompson I.M. Jones Spectrum of somatic mutation at the hypoxanthine phosphoribosyltransferase (hprt) gene of healthy people Carcinogenesis 17 1996 1871 1883
    • (1996) Carcinogenesis , vol.17 , pp. 1871-1883
    • Burkhart-Schultz, K.J.1    Thompson, C.L.2    Jones, I.M.3
  • 84
    • 0033543945 scopus 로고    scopus 로고
    • Failure of T lymphocytes from elderly humans to enter the cell cycle is associated with low Cdk6 activity and impaired phosphorylation of Rb protein
    • A. Arbogast S. Boutet M.A. Phelouzat O. Plastre R. Quadri J.J. Proust Failure of T lymphocytes from elderly humans to enter the cell cycle is associated with low Cdk6 activity and impaired phosphorylation of Rb protein Cell. Immunol. 197 1999 46 54
    • (1999) Cell. Immunol. , vol.197 , pp. 46-54
    • Arbogast, A.1    Boutet, S.2    Phelouzat, M.A.3    Plastre, O.4    Quadri, R.5    Proust, J.J.6
  • 85
    • 0031958676 scopus 로고    scopus 로고
    • Differential expression of p53 tumor suppressor protein and IL-2 in activated T cells from elderly humans
    • S.E. VanAman R.L. Whisler Differential expression of p53 tumor suppressor protein and IL-2 in activated T cells from elderly humans J. Interferon Cytokine Res. 18 1998 315 320
    • (1998) J. Interferon Cytokine Res. , vol.18 , pp. 315-320
    • VanAman, S.E.1    Whisler, R.L.2
  • 86
    • 0029968318 scopus 로고    scopus 로고
    • Shortened telomeres in clonally expanded CD28−CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts
    • J. Monteiro F. Batliwalla H. Ostrer P.K. Gregersen Shortened telomeres in clonally expanded CD28−CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts J. Immunol. 156 1996 3587 3590
    • (1996) J. Immunol. , vol.156 , pp. 3587-3590
    • Monteiro, J.1    Batliwalla, F.2    Ostrer, H.3    Gregersen, P.K.4
  • 87
    • 0031463644 scopus 로고    scopus 로고
    • Tales of Tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging
    • N-p. Weng L.D. Palmer B.L. Levine H.C. Lane C.H. June R.J. Hodes Tales of Tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging Immunol. Rev. 160 1997 43 54
    • (1997) Immunol. Rev. , vol.160 , pp. 43-54
    • Weng, N-p.1    Palmer, L.D.2    Levine, B.L.3    Lane, H.C.4    June, C.H.5    Hodes, R.J.6
  • 88
    • 0031837486 scopus 로고    scopus 로고
    • Age-dependent characteristics of protection v. susceptibility to Plasmodium falciparum
    • J.K. Baird Age-dependent characteristics of protection v. susceptibility to Plasmodium falciparum Ann. Trop. Med. Parasitol. 92 1998 367 390
    • (1998) Ann. Trop. Med. Parasitol. , vol.92 , pp. 367-390
    • Baird, J.K.1
  • 89
    • 0033757875 scopus 로고    scopus 로고
    • Impact of age-related immune dysfunction on risk of infections
    • S.C. Castle Impact of age-related immune dysfunction on risk of infections Z. Gerontol. Geriat. 33 2000 341 349
    • (2000) Z. Gerontol. Geriat. , vol.33 , pp. 341-349
    • Castle, S.C.1
  • 90
    • 0004267413 scopus 로고
    • The Immunologic Theory of Aging
    • R.L. Walford The Immunologic Theory of Aging 1969 Munksgaard Copenhagen, Denmark
    • (1969)
    • Walford, R.L.1


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