Activation of T cells by superantigen: Cytokine production but not apoptosis depends on MEK-1 activity

European Journal of Immunology

Volumn 28, Issue 11, 1998, Pages 3749-3754

  Adler, Barbara ^a   Weber, Georg F ^a   Cantor, Harvey ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DFCI   (United States)

Author keywords

Apoptosis; Interleukin; MEK; Superantigen; T cell development

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYTOKINE; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0031739674     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199811)28:11<3749::AID-IMMU3749>3.0.CO;2-I     Document Type: Article

References (23)

1. Letourneur, F. and Klausner, R. D., Activation of T-cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon. Science 1992. 255: 79-82.
2. Wegener, A.-M. K., Letourneur, R, Hoeveler, A., Brocker, T., Luton, F. and Malissen, B., The T-cell receptor/CD3 complex is composed of at least two autonomous transduction molecules. Cell 1992. 68: 83-95.
3. Weber, G. F. and Cantor, H., Phosphatidylinositol synthesis is a proximal event in intracellular signalling coupled to TCR ligation: Differential induction by conventional antigen and retroviral superantigen. J. Immunol. 1994. 152: 4433-4443.
4. Weber, G. F. and Cantor, H., A signalling pathway coupled to T-cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death. Immunity 1995. 2: 363-372.
5. Alberola-lla, J., Forbush, K. A., Seger, R., Krebs, E. G. and Perlmutter, R. M., Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 1995. 373: 620-623.
6. Swan, K. A., Alberola-lla, J., Gross, J. A., Appleby, M. W., Forbush, K. A., Thomas, J. F. and Perlmutter, R. M., Involvement of p21ras distinguishes positive and negative selection in thymocytes. EMBO J. 1995. 14: 276-285.
7. Franklin, R. A., Tordai, A., Patel, H., Gardner, A. M., Johnson, G. L. and Gelfand, E. W., Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/ MEK/MAPK cascade in human T lymphocytes. J. Clin. Invest. 1994. 93: 2134-2140.
8. Whitehurst, C. E., Boulton, T. G., Cobb, M. H. and Geppert, T. D., Extracellular signal-regulated kinases in T cells. Anti-CD3 and 4 beta-phorbol 12-myristate 13-acetate-induced phosphorylation and activation. J. Immunol. 1992. 148: 3230-3237.
9. Whitehurst, C. E., Owaki, H., Bruder, J. T., Rapp, U. R. and Geppert, T. D., The MEK kinase activity of the catalytic domain of RAF-1 is regulated independently of Ras binding in T cells. J. Biol. Chem. 1995. 270: 5594-5599.
10. Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J. and Saltiel, A. R., A synthetic inhibitor of the mitogenactivated protein kinase cascade. Proc. Natl. Acad. Sci. USA 1995. 92: 7686-7689.
11. Seger, R., Seger, D., Reszka, A. A., Munar, E. S., Eldar-Finkelman, H., Dobrowoloska, G., Jensen, A. M., Campbell, J. S., Fischer, E. H. and Krebs, E. G., Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII. J. Biol. Chem. 1994. 269: 25699-25709.
12. Ucker, D. S., Ashwell, J. D. and Nickas, G., Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation. J. Immunol. 1989. 143: 3461-3469.
13. Frank, S. J., Niklinska, B. B., Orloff, D. G., Mercep, M., Ashwell, J. D. and Klausner, R. D., Structural mutations of the T cell receptor zeta chain and its role in T cell activation. Science 1990. 249: 174-177.
14. Rudd, C. E., Janssen, O., Prasad, K. V., Raab, M., daSilva, A., Telfer, J. C. and Yamamoto, M., src-related protein tyrosine kinases and their surface receptors. Biochim. Biophys. Acta 1993. 1155: 239-266.
15. Negishi, I., Motoyama, N., Nakayama, K., Senju, S., Hatakeyama, S., Zhang, Q., Chan, A. C. and Loh, D. Y., Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 1995. 376: 435-438.
16. Hashimoto, K., Sohn, S. J., Levin, S. D., Tada, T., Perlmutter, R. M. and Nakayama, T., Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection. J. Exp. med. 1996. 184: 931-943.
17. Saijo, K., Park, S. Y., Ishida, Y., Arase, H. and Saito, T., Crucial role of Jak3 in negative selection of self-reactive T cells. J. Exp. Med. 1997. 185: 351-356.
18. Ju, S. T., Panka, D. J., Cui, H., Ettinger, R., el-Khatib, M., Sherr, D. H., Stanger, B. Z. and Marshak-Rothstein, A., Fas (CD95)/FasL interactions required for programmed cell death after T cell activation. Nature 1995. 373: 444-448.
19. DeSilva, D. R., Jones, E. A., Favata, M. F., Jaffee, B. D., Magolda, R. L., Trzaskos, J. M. and Scherle, P. A., Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy. J. Immunol. 1998. 160: 4175-4181.
20. Murphy, K. M., Heimberger, A. B. and Loh, D. Y., Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRIo thymocytes in vivo. Science 1990. 250: 1720-1723.
21. Spinella, D. G., Hansen, T. H., Walsh, W. D., Behlke, M. A., Tillinghast, J. P., Chou, H. S., Whiteley, P. J., Kapp, J. A., Pierce, C. W., Shevach, E. M. and Loh, D. Y., Receptor diversity of insulin-specific T cell lines from C57BL/6 (H-2b) mice. J. Immunol. 1987. 138: 3991-3995.
22. Mage, M. G., McHugh, L. L. and Rothstein, T. L., Mouse lymphocytes with and without surface immunoglobulin. Preparative scale separation in polystyrene tissue culture dishes coated with specifically purified antiimmunoglobulin. J. Immunol. Methods 1977. 15: 47-56.
23. Sgonc, R., Boeck, G., Dietrich, H., Gruber, J., Recheis, H. and Wick, G., Simultaneous determination of cell surface antigens and apoptosis. Trends Genet. 1994. 10: 41-42.