Differential expression of p53 tumor suppressor protein and IL-2 in activated T cells from elderly humans

Journal of Interferon and Cytokine Research

Volumn 18, Issue 5, 1998, Pages 315-320

  VanAman, Scott E ^a   Whisler, Ronald L ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CYTOKINE; INTERLEUKIN 2; MONOCLONAL ANTIBODY; OKT 3; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN BCL 2; PROTEIN P53; RETINOBLASTOMA PROTEIN;

AGED; AGING; ARTICLE; CELL AGING; CELL GROWTH; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LYMPHOCYTE ACTIVATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; T LYMPHOCYTE ACTIVATION; TUMOR SUPPRESSOR GENE;

EID: 0031958676     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1998.18.315     Document Type: Article

References (42)

1. ATADJA, P.W., STRINGER, K.F., and RIABOWOL, K.T. (1994). Loss of serum response element-binding activity and hyperphosphorylation of serum response factor during cellular aging. Mol. Cell. Biol. 14, 4991-4999.
2. GOODMAN, L., and STEIN, G.H. (1994). Basal and induced amounts of interleukin-6 mRNA decline progressively with age in human fibroblasts. J. Biol. Chem. 269, 19250-19255.
3. CHOW, M., and RUBIN, H. (1996). Evidence for cellular aging in long-term confluent cultures: heritable impairment of proliferation, accumulation of age pigments and their loss in neoplastic transformation. Mech. Ageing Dev. 89, 165-183.
4. GILLIS, S., KOZAK, R., DURANTE, M., and WEKSLER, M.E. (1981). Immunologic studies of aging. Decreased production and response to T cell growth factor by lymphocytes from aged humans. J. Clin. Invest. 67, 937-942.
5. MURASKO, D.M., NELSON, B.J., SILVER, R., MATOUR, D., and KAYE, D. (1986). Immunologic response in an elderly population with a mean age of 85. Am. J. Med. 81, 612-618.
6. NAGEL, J.E., CHOPRA, R.K., CHREST, F.J., McCOY, M.T., SCHNEIDER, E.L., HOLBROOK, N.J., and ADLER, W.H. (1988). Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J. Clin. Invest. 81, 1096-1102.
7. MILLER, R.A. (1991). Aging and immune function. Int. Rev. Cytol. 124, 187-215.
8. SONG, L., KIM, Y.H., CHOPRA, R.K., PROUST, J.J., NAGEL, J.E., NORDIN, A.A., and ADLER, W.H. (1993). Age-related effects in T cell activation and proliferation. Exp. Gerontol. 28, 313-321.
9. HODES, R.J. (1995). Molecular alterations in the aging immune system. J. Exp. Med. 182, 1-3.
10. PAWELEC, G. (1995). Molecular and cell biological studies of ageing and their application to considerations of T lymphocyte immunosenescence. Mech. Ageing Dev. 79, 1-32.
11. MILLER, R.A. (1996). The aging immune system: primer and prospectus. Science 273, 70-74.
12. PAHLAVANI, M.A., and RICHARDSON, A. (1996). The effect of age on the expression of interleukin-2. Mech. Ageing Dev. 89, 125-154.
13. WHISLER, R.L., LIU, B.Q., and CHEN, M. (1996). Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT. Cell Immunol. 169, 185-195.
14. MILLER, R.A., PHILOSOPHE, B., GINIS, I., WEI, G., and JACOBSON, B. (1989). Defective control of cytoplasmic calcium concentration in T lymphocytes from old mice. J. Cell. Physiol. 138, 175-182.
15. MILLER, R.A., FLURKEY, K., and PATEL, H. (1990). Signal transduction pathways in T lymphocytes from old mice. Aging Immunol. Infect. Dis. 2, 97-103.
16. GROSSMANN, A., LEDBETTER, J.A., and RABINOVITCH, P.S. (1990) Aging-related deficiency in intracellular calcium response to anti-CD3 or concanavalin A in murine T-cell subsets. J. Gerontol. Biol. Sci. 45, B81-B86.
17. MILLER, R.A. (1991). Accumulation of hyporesponsive, calcium extruding memory T cells as a key feature of age-dependent immune dysfunction. Clin. Immunol. Immunopathol. 58, 305-317.
18. SHI, J., and MILLER, R.A. (1992). Tyrosine-specific protein phosphorylation in response to anti-CD3 antibody is diminished in old mice. J. Gerontol. Biol. Sci. 47, B147-B153.
19. SHI, J., and MILLER, R.A. (1993). Differential tyrosine-specific protein phosphorylation in mouse T lymphocyte subsets: effect of age. J. Immunol. 151, 730-739.
20. WHISLER, R.L., NEWHOUSE, Y.G., DONNERBERG, R.L., and TOBIN, C.M. (1991). Characterization of intracellular ionized calcium responsiveness and inositol phosphate production among resting and stimulated peripheral blood T cells from elderly humans. Aging Immunol. Infect. Dis. 3, 27-36.
21. MILLER, R.A. (1996). Calcium signals in T lymphocytes from old mice. Life Sci. 59, 469-475.
22. CLARKE, A.R., PURDIE, C.A., HARRISON, D.J., MORRIS, R.G., BIRD, C.C., HOOPER, M.L. and WYLLIE, A.H. (1993). Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849-852.
23. LOWE, S.W., RULEY, H.E., JACKS, T., and HOUSMAN, D.E. (1993). p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74, 957-967.
24. WU, X., and LEVINE, A.J. (1994). p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91, 3602-3606.
25. QIN, X.-Q., LIVTNGSTON, D.M., KAELIN, W.G. Jr., and ADAMS, P.D. (1994). Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91, 10918-10922.
26. CANMAN, C.E., GILMER, T.M., COUTTS, S.B., and KASTAN, M.B. (1995). Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev. 9, 600-611.
27. ULLRICH, S.J., ANDERSON, C.W., MERCER, W.E., and APELLA, E. (1992). The p53 tumor suppressor protein, a modulator of cell proliferation. J. Biol. Chem. 267, 15259-15262.
28. TERADA, N., LUCAS, J.J., and GELFAND, E.W. (1991). Differential regulation of the tumor suppressor molecules, retinoblastoma susceptibility gene product (Rb) and p53, during cell cycle progression of normal human T cells. J. Immunol. 147, 698-704.
29. STAIANO-COICO, L., DARZYNKIEWICZ, Z., HEFTON, J.M., DUTKOWSKI, R., DARLINGTON, G.J., and WEKSLER, M.E. (1983). Increased sensitivity of lymphocytes from people over 65 to cell cycle arrest and chromosomal damage. Science 219, 1335-1337.
30. - T cells with aging. Mech. Ageing Dev. 94, 123-134.
31. PHELOUZAT, M.A., ARBOGAST, A., LAFORGE, T.S., QUADRI, R.A., and PROUST, J.J. (1996). Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence. Mech. Ageing Dev. 88, 25-38.
32. INK4 and telomerase in immortalization of human cells. Oncogene 11, 971-976.
33. MEMON, S.A., MORENO, M.B., PETRAK, D., and ZACHARCHUK, C.M. (1995). Bcl-2 blocks glucocorticoid-but not Fas- or activation-induced apoptosis in a T cell hybridoma. J. Immunol. 155, 4644-4652.
34. OTANI, H., ERDOS, M., and LEONARD, W.J. (1993). Tyrosine kinase(s) regulate apoptosis and bcl-2 expression in a growth factor-dependent cell line. J. Biol. Chem. 268, 22733-22736.
35. LIGTHART, G.J., CORBERAND, J.X., FOURNIER, C., GALANAUD, P., HIJMANS, W., KENNES, B., MULLER-HERMELINK, H.K., and STEINMANN, G.G. (1984). Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech. Ageing Dev. 28, 47-55.
36. WYSOCKI, L.J., and SATO, V.L. (1978). "Panning" for lymphocytes: a method for cell selection. Proc. Natl. Acad. Sci. USA 75, 2844-2848.
37. GRANELLI-PIPERNO, A., KEANE, M., and STEINMAN, R.M. (1989). Growth factor production and requirements during the proliferative response of human T lymphocytes to anti-CD3 monoclonal antibody. J. Immunol. 142, 4138-4143.
38. WHITEHURST, C.E., BOULTON, T.G., COBB, M.H., and GEPPERT, T.D. (1992). Extracellular signal-regulated kinases in T cells. Anti-CD3 and 4B-phorbol 12-myristate 13-acetate-induced phosphorylation and activation. J. Immunol. 148, 3230-3237.
39. LAEMMLI, U.K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
40. AKBAR, A.N., BORTHWICK, N., SALMON, M., GOMBERT, W., BOFILL, M., SHAMSADEEN, N., PILLING, D., PETT, S., GRUNDY, J.E., and JANOSSY, G. (1993). The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. J. Exp. Med. 178, 427-438.
41. CHOPRA, R.K., HOLBROOK, N.J., POWERS, D.C., McCOY, M.T., ADLER, W.H., and NAGEL, J.E. (1991). Interleukin 2, interleukin 2 receptor and interferon-γ synthesis, and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans. Clin. Immunol. Immunopathol. 53, 297-308.
42. MURASKO, D.M., NELSON, B.J., MATOUR, D., GOONEWARDENE, I.M., and KAYE, D. (1991). Heterogeneity of changes in lymphoproliferative ability with increasing age. Exp. Gerontol. 26, 269-279.