Solid-phase synthesis of bleomycin group antibiotics. Construction of a 108-member deglycobleomycin library

Journal of the American Chemical Society

Volumn 125, Issue 27, 2003, Pages 8218-8227

  Leitheiser, Christopher J ^a   Smith, Kenneth L ^a   Rishel, Michael J ^a   Hashimoto, Shigeki ^a   Konishi, Kazuhide ^a   Thomas, Craig J ^a   Li, Chunhong ^a   McCormick, Michael M ^a   Hecht, Sidney M ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SOLID-PHASE SYNTHESIS;

DNA; MASS SPECTROMETRY; RNA; SYNTHESIS (CHEMICAL);

ANTIBIOTICS;

ANTIBIOTIC AGENT; BLEOMYCIN; BLEOMYCIN DERIVATIVE; DEGLYCOBLEOMYCIN; PLASMID DNA; UNCLASSIFIED DRUG;

ARTICLE; DNA CLEAVAGE; DNA SUPERCOILING; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; SOLID;

AMINO ACIDS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA, SUPERHELICAL; FLUORENES; METHIONINE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0038682513     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja021388w     Document Type: Article

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