Definition of the effect and role of the bleomycin A2 valerate substituents: Preorganization of a rigid, compact conformation implicated in sequence-selective DNA cleavage

Journal of the American Chemical Society

Volumn 120, Issue 36, 1998, Pages 9149-9158

  Boger, Dale L ^a   Ramsey, Timothy M ^a   Cai, Hui ^a   Hoehn, Silvia T ^b   Stubbe, JoAnne ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN A2 VALERATE; BLEOMYCIN DERIVATIVE; DEGLYCOBLEOMYCIN A2; DOUBLE STRANDED DNA; METHYL GROUP; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ARTICLE; DNA CLEAVAGE; DRUG CONFORMATION; DRUG SYNTHESIS; HYDROGEN BOND;

EID: 0032538003     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9816640     Document Type: Article

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40. 3 values of 1.3 and 3.7 kcal/mol. respectively.
41. Full characterization of intermediates 9b-e, 10a-e, 11a-e, 12a-e, 14a-e, 15a-e, 17a-e, and 19a-e is provided in Supporting Information.