Nonpeptidic chymase inhibitors: Design and structure-activity relationships of pyrimidinone derivatives based on the predicted binding mode of a peptidic inhibitor

Current Pharmaceutical Design

Volumn 9, Issue 15, 2003, Pages 1191-1199

  Akahoshi, Fumihiko ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [5 AMINO 2 (4 FLUOROPHENYL) 1,6 DIHYDRO 6 OXO 1 PYRIMIDINYL] N [1 [(5 METHOXYCARBONYL 2 BENZOXAZOLYL)CARBONYL] 2 PHENYLETHYL]ACETAMIDE; ACID ANHYDRIDE; BETA LACTAM DERIVATIVE; CEPHALOSPORIN DERIVATIVE; CHYMASE; CHYMASE INHIBITOR; COUMARIN DERIVATIVE; FLUORIDE; HETEROCYCLIC COMPOUND; HYDANTOIN DERIVATIVE; N [1 BENZYL 2,3 DIOXO 6 (2 PYRIDYLOXY)HEXYL] 2 (5 FORMYLAMINO 1,6 DIHYDRO 6 OXO 2 PHENYL 1 PYRIMIDINYL)ACETAMIDE; PYRIMIDINONE DERIVATIVE; QUINAZOLINE DERIVATIVE; SERINE PROTEINASE INHIBITOR; SULFONYL HALIDE; UNCLASSIFIED DRUG; Y 40018; Y 40079;

DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG HALF LIFE; DRUG POTENCY; DRUG SPECIFICITY; DRUG STABILITY; ENZYME MECHANISM; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PREDICTION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHYMASES; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; PEPTIDES; PYRIMIDINONES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038663069     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612033454964     Document Type: Review

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