Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase

Journal of Medicinal Chemistry

Volumn 40, Issue 14, 1997, Pages 2156-2163

  Niwata, S ^a   Fukami, H ^a   Sumida, M ^a   Ito, A ^a   Kakutani, S ^a   Saitoh, M ^a   Suzuki, K ^a   Imoto, M ^a   Shibata, H ^a   Imajo, S ^a   Kiso, Y ^a   Tanaka, T ^a   Nakazato, H ^a   Ishihara, T ^a   Takai, S ^a   Yamamoto, D ^a   Shiota, N ^a   Miyazaki, M ^a   Okunishi, H ^a   Kinoshita, A ^a   Urata, H ^a   Arakawa, K ^a   more..

^a SUNTORY LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(4 CHLOROPHENYL)SULFONYL] 1 (4 CHLOROPHENYL)IMIDAZOLINE 2,4 DIONE; CHYMASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HYDROPHOBICITY; MOLECULAR INTERACTION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CHYMASES; COMPUTER GRAPHICS; HUMANS; IMIDAZOLES; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONTE CARLO METHOD; MYOCARDIUM; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0030871679     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960793t     Document Type: Article

References (26)