An orally active chymase inhibitor, BCEAB, suppresses heart chymase activity in the hamster

Japanese Journal of Pharmacology

Volumn 86, Issue 1, 2001, Pages 124-126

  Takai, S ^a   Jin, D ^a   Sakaguchi, M ^a   Kirimura, K ^a   Miyazaki, M ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Chymase; Inhibitor; Oral administration

Indexed keywords

4 [1 [BIS(4 METHYLPHENYLMETHYL)CARBAMOYL] 3 (2 ETHOXYBENZYL) 4 OXOAZETIDINE 2 YLOXY]BENZOIC ACID; CHYMASE; DIPEPTIDYL CARBOXYPEPTIDASE; ELASTASE; LISINOPRIL; SERINE PROTEINASE INHIBITOR; TRYPTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOG; DRUG INHIBITION; ENZYME ACTIVITY; HAMSTER; HEART CONTRACTION; ISOLATED ARTERY; NONHUMAN;

EID: 0034994411     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.86.124     Document Type: Article

References (11)

1. Characterization of chymase from human vascular tissues
2. Induction of chymase that forms angiotensin II in the monkey atherosclerotic aorta
3. Angiotensin II generation by mast cell alpha- and beta-chymases
4. Purification and characterization of angiotensin II-generating chymase from hamster cheek pouch
5. Angiotensin I conversion by human and rat chymotryptic proteinases
6. Marked species-difference in the vascular angiotensin II-forming pathways: Humans versus rodents
7. Inhibition of chymase reduces vascular proliferation in dog grafted veins
8. Characterization of recombinant human chymase expressed in Escherichia coli
9. Characteristics of monkey tryptase purified from cheek pouch vascular tissues
10. Effect of an angiotensin II receptor antagonist, candesartan cilexetil, on canine intima hyperplasia after balloon injury
11. Angiotensin II receptor antagonist, L-158,809, prevents intimal hyperplasia in dog grafted veins