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Volumn 9, Issue 2, 2001, Pages 301-315

Non-peptidic inhibitors of human chymase. Synthesis, structure-activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones

(11) Akahoshi, Fumihiko a Ashimori, Atsuyuki a Yoshimura, Takuya a Imada, Teruaki a Nakajima, Masahide a Mitsutomi, Naoko a Kuwahara, Shigeki a Ohtsuka, Tatsuyuki a Fukaya, Chikara a Miyazaki, Mizuo b Nakamura, Norifumi a

a Welfide Corporation (Japan)

b OSAKA MEDICAL COLLEGE (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [5 AMINO 2 (4 FLUOROPHENYL) 6 OXO 1,6 DIHYDRO 1 PYRIMIDINYL] N (1 BENZYL 3,3,3 TRIFLUORO 2 OXOPROPYL)ACETAMIDE; 2 [5 AMINO 6 OXO 2 (3 TOLYL) 1,6 DIHYDRO 1 PYRIMIDINYL] N (1 BENZYL 3,3,3 TRIFLUORO 2 OXOPROPYL)ACETAMIDE; CHYMASE; ENZYME INHIBITOR; PHENYL GROUP; PHENYLALANINE; PROLINE; UNCLASSIFIED DRUG; VALINE;

ANIMAL EXPERIMENT; ARTICLE; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL AVAILABILITY; CATTLE; CHYMASES; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; KETONES; KINETICS; PYRIMIDINES; RATS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035085173 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/S0968-0896(00)00244-3 Document Type: Article

Times cited : (16)

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