Oral administration of a specific chymase inhibitor, NK3201, inhibits vascular proliferation in grafted vein

Life Sciences

Volumn 69, Issue 15, 2001, Pages 1725-1732

  Takai, Shinji ^a   Jin, Denan ^a   Nishimoto, Masayoshi ^a   Yuda, Atsushi ^a   Sakaguchi, Masato ^a   Kamoshita, Keiichi ^b   Ishida, Koichi ^b   Sukenaga, Yoshikazu ^b   Sasaki, Shinjiro ^a   Miyazaki, Mizuo ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b NIPPON KAYAKU CO LTD   (Japan)

Author keywords

Angiotensin converting enzyme; Chymase; Graft; Inhibitor

Indexed keywords

ACETAMIDE DERIVATIVE; ANGIOTENSIN I; CHYMASE; CHYMASE INHIBITOR; CHYMOSTATIN; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; N [1 BENZYL 2,3 DIOXO 6 (2 PYRIDYLOXY)HEXYL] 2 (5 FORMYLAMINO 1,6 DIHYDRO 6 OXO 2 PHENYL 1 PYRIMIDINYL)ACETAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY BYPASS; ARTERY CONSTRICTION; ARTICLE; COMMON CAROTID ARTERY; CONTROLLED STUDY; DOG; DRUG EFFECT; ENZYME ACTIVITY; IC 50; JUGULAR VEIN; NONHUMAN;

ACETAMIDES; ADMINISTRATION, ORAL; ANGIOTENSIN I; ANIMALS; CAROTID ARTERIES; CELL DIVISION; CHYMASES; CULTURE TECHNIQUES; DOGS; DRUG ANTAGONISM; GRAFT OCCLUSION, VASCULAR; MUSCLE CONTRACTION; PEPTIDYL-DIPEPTIDASE A; PYRIMIDINES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SPECIES SPECIFICITY; VEINS;

EID: 0035979678     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01255-3     Document Type: Article

References (21)

1. Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury
2. Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells
3. The renin-angiotensin system in the heart and vascular wall: New therapeutic aspects
4. Induction of chymase that forms angiotensin II in the monkey atherosclerotic aorta
5. Purification and characterization of angiotensin II-generating chymase from hamster cheek pouch
6. Marked species-difference in the vascular angiotensin II-forming pathways: Humans versus rodents
7. Characterization of chymase from human vascular tissues
8. The proliferative response to vascular injury is suppressed by angiotensin-converting enzyme inhibition
9. Cilazapril inhibits wall thickening of vein bypass graft in the rat
10. Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary angioplasty? Results of the MERCATOR study: A multicenter, randomized, double-blind placebo-controlled trial
11. Effects of angiotensin converting enzyme inhibition with cilazapril on intimal hyperplasia in injured arteries and vascular grafts in the baboon
12. Effect of an angiotensin II receptor antagonist, candesartan cilexetil, on canine intima hyperplasia after balloon injury
13. Inhibition of chymase reduces vascular proliferation in dog grafted veins
14. Characterization of recombinant human chymase expressed in Escherichia coli
15. Effects of daphnodorin A, daphnodorin B and daphnodorin C on human chymase-dependent angiotensin II formation
16. Angiotensin II receptor antagonist, L-158,809, prevents intimal hyperplasia in dog grafted veins
17. Human MCTC type of mast cell granule: The uncommon occurrence of discrete scrolls associated with focal absence of chymase
18. Chymase-dependent angiotensin II formation in human vascular tissue
19. Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase
20. Cleavage of type I pro-collagen by human mast cell chymase initiates collagen fibril formation and generates a unique carboxyl-terminal propeptide
21. Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture