Chymase processes big-endothelin-2 to endothelin-2-(1-31) that induces contractile responses in the isolated monkey trachea

European Journal of Pharmacology

Volumn 358, Issue 3, 1998, Pages 229-233

  Takai, Shinji ^a   Shiota, Naotaka ^a   Jin, Denan ^a   Miyazaki, Mizuo ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Big endothelin 1; Big endothelin 2; Chymase; Constriction; Monkey

Indexed keywords

BIG ENDOTHELIN 1; BIG ENDOTHELIN 2; CHYMASE; CHYMOSTATIN; ENDOTHELIN 1; ENDOTHELIN 2;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; SMOOTH MUSCLE CONTRACTION; TRACHEA MUSCLE;

ANIMALS; CHYMASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELINS; MACACA FASCICULARIS; MUSCLE CONTRACTION; OLIGOPEPTIDES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; TRACHEA;

EID: 0032500803     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00622-0     Document Type: Article

References (10)

1. Emoto, N., Yanagisawa, M., 1995. Endothelin-converting enzyme-2 is a membrane-bound phosphoramidon-sensitive metalloprotease acidic pH optimum. J. Biol. Chem. 270, 15262-15268.
2. Hanson, G.C., Anderson, K.-E., Gyllstedt, E., Hogestatt, E.D., Lindeberg, B.F., 1997. Hydrolysis of big endothelin-1 by a serine protease in the membrane fraction of human lung. Regul. Pept. 68, 63-69.
3. Le Trong, H., Neurath, H., Woodbury, R.G., 1987. Substrate specificity of the chymotrypsin-like protease in secretory granules isolated from rat mast cell. Proc. Natl. Acad. Sci. USA 84, 364-367.
4. Matin, R., Tam, E.K., Nadel, J.A., Caughey, G.H., 1992. Distribution of chymase-containing mast cells in human bronchi. J. Histochem. Cytochem. 40, 781-786.
5. Nakano, A., Kishi, F., Minami, K., Wakabayashi, H., Nakaya, Y., Kido, H., 1997. Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acid-length endothelins by chymase from human mast cells. J. Immunol. 159, 1987-1992.
6. Okunishi, H., Oka, Y., Shiota, N., Kawamoto, T., Song, K., Miyazaki, M., 1993. Marked species-difference in the vascular angiotensin II-forming pathways: Human versus rodents. Jpn. J. Pharmacol. 62, 207-210.
7. Sawamura, T., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T., Kimura, S., 1993. Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane. Biochim. Biophys. Acta 1161, 295-302.
8. Takai, S., Shiota, N., Yamamoto, D., Okunishi, H., Miyazaki, M., 1996. Purification and characterization of angiotensin II-generating chymase from hamster cheek pouch. Life Sci. 58, 591-597.
9. Takai, S., Shiota, N., Kobayashi, S., Matsumura, E., Miyazaki, M., 1997. Induction of chymase that forms angiotensin II in the monkey atherosclerotic aorta. FEBS Lett. 412, 86-90.
10. Urata, H., Kinoshita, A., Misono, K., Bumpus, M., Husain, A., 1990. Identification of highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J. Biol. Chem. 265, 22348-22357.