Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with glu at P3 site

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 8, 1998, Pages 919-924

  Eda, Masahiro ^a   Ashimori, Atsuyuki ^a   Akahoshi, Fumihiko ^a   Yoshimura, Takuya ^a   Inoue, Yoshihisa ^a   Fukaya, Chikara ^a   Nakajima, Masahide ^a   Fukuyama, Hajime ^a   Imada, Teruaki ^a   Nakamura, Norifumi ^a  

^a Green Cross Company   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMASE; CHYMOTRYPSIN A; DIFLUOROMETHYLENE KETONE DERIVATIVE; ENZYME INHIBITOR; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG POTENCY; ENZYME BINDING; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATTLE; CHYMASES; CHYMOTRYPSIN; GLUTAMIC ACID; HUMANS; INDICATORS AND REAGENTS; KETONES; KINETICS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MYOCARDIUM; OLIGOPEPTIDES; RATS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17144462307     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00132-2     Document Type: Article

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