Synthesis, structure - Activity relationships, and pharmacokinetic profiles of nonpeptidic α-keto heterocycles as novel inhibitors of human chymase

Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2001, Pages 1286-1296

  Akahoshi, F ^a   Ashimori, A ^a   Sakashita, H ^a   Yoshimura, T ^a   Eda, M ^a   Imada, T ^a   Nakajima, M ^a   Mitsutomi, N ^a   Kuwahara, S ^a   Ohtsuka, T ^a   Fukaya, C ^c   Miyazaki, M ^b   Nakamura, N ^d  

^a Welfide Corporation   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

^c Welfide Corporation   (Japan)

^d Welfide International Corp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOXAZOLE DERIVATIVE; CARBONYL DERIVATIVE; CHYMASE; CHYMASE INHIBITOR; ENZYME INHIBITOR; HETEROCYCLIC COMPOUND; PROTEINASE; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG; Y 40079;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZOXAZOLES; BIOLOGICAL AVAILABILITY; CHYMASES; HUMANS; HYDROLYSIS; LIVER; MALE; PROTEASE INHIBITORS; PYRIMIDINONES; RATS; RATS, SPRAGUE-DAWLEY; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035848583     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000496v     Document Type: Article

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