N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: Structural requirements for potent inhibition of α-chymotrypsin

Journal of Medicinal Chemistry

Volumn 42, Issue 2, 1999, Pages 312-323

  Iijima, Kiyoko ^a   Katada, Jun ^a   Yasuda, Emiko ^a   Uno, Isao ^a   Hayashi, Yoshio ^a  

^a NIPPON STEEL CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMOTRYPSIN A; N [2,2 DIMETHYL 3 (N (4 CYANOBENZOYL)AMINO)NONANOYL]PHENYLALANINE ETHYL ESTER; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; PROTEINASE INHIBITION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CATTLE; CHYMOTRYPSIN; ENZYME REACTIVATORS; HUMANS; HYDRAZINES; HYDROLYSIS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PHENYLALANINE; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPSIN INHIBITORS;

EID: 0032910486     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980562h     Document Type: Article

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