Mechanisms of allergic skin inflammation

Atopic Dermatitis

Volumn , Issue , 2002, Pages 145-162

  Akdis, Mübeccel ^a   Trautmann, Axel ^a   Blaser, Kurt ^a   Akdis, Cezmi A ^a  

^a SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0038506245     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (83)

1. CA Akdis, M Akdis, A Trautmann, K Blaser. Immune regulation in atopic dermatitis. Current Opin Immunol 12:641-646, 2000.
2. + memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern. IgG4 counter-regulation by CLA~ memory T cells. J Immunol 159: 4611-4619, 1997.
3. LF Santamaria Babi, LJ Picker, MT Perez Soler, K Drzimalla, P Flohr, K Blaser, C Hauser. Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen. J Exp Med 181:1935-1940, 1995.
4. Y Shimada, S Sato, M Hasegawa, TF Tedder, K Takehara. Elevated serum L-selectin levels and abnormal regulation of L-selection expression on leukocytes in atopic dermatitis: soluble L-selectin levels indicate disease severity. J Allergy Clin Immunol 104:163-168, 1999.
5. M Akdis, H-U Simon, L Weigl, O Kreyden, K Blaser, CA Akdis. Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis. J Immunol 163:466-475, 1999.
6. CA Akdis, M Akdis, D Simon, B Dibbert, M Weber, S Gratzl, O Kreyden, R Disch, B Wuthrich, K Blaser, H-U Simon. T cells and T cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis. J Invest Dermatol 113: 628-634, 1999.
7. FC Van Reijsen, CAFM Bruijnzeel-Komen, FS Kalthoff, E Maggi, S Romagnani, JKT Westland, GC Mudde. Skin-derived aero-allergen specific T cell clones of Th2 phenotype in patients with atopic dermatitis. J Allergy Clin Immunol 90:184-193, 1992.
8. VA Varney, QA Hamid, M Gaga, S Ying, M Jacobson, AJ Frew, AB Kay, SR Durham. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 92:644-651, 1993.
9. T Werfel, A Morita, M Grewe, H Renz, U Wahn, J Krutmann, A Kapp. Allergen-specificity of skin-infiltrating T-cells is not restricted to a type 2 cytokine pattern in chronic skin lesions of atopic dermatitis. J Invest Dermatol 107:871-876, 1996.
10. AJ Frew, AB Kay. The relationship between infiltrating CD4+ lymphocytes, activated eosinophils, and the magnitude of the allergen-induced late phase cutaneous reactions in man. J Immunol 141:4158-4164, 1988.
11. KJ Abernathy-Carver, HA Sampson, LJ Picker, DYM Leung. Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen. J Clin Invest 95:913-918, 1995.
12. EY Denkers, P Caspar, A Sher. Toxoplasma gondii possesses a superantigen activity that selectively expands murine T cell receptor V P 5-bearing CD8+ lymphocytes. J Exp Med 180:985-994, 1994.
13. MC Chou, SC Lee, YS Lin, HY Lei. V P 8+ CD4~ CD8~ subpopulation induced by staphylococcal enterotoxin B. Immunol Let 55:85-91, 1997.
14. DA Schmitt, T Bieber, JP Cazenave, D Hanau. Fc receptors of human Langerhans cells. J Invest Dermatol 94:15S-21S, 1990.
15. JE Leyden, RR Marpies, AM Kligman. Staphylococcus aureus in the lesions of atopic dermatitis. Br J Dermatol 90:525-530, 1974.
16. P Strange, L Skov, S Lisby, PL Nielsen, O Baadsgaard. Staphylococcal enterotoxin B applied on intact normal and intact atopic skin induces dermatitis. Arch Dermatol132:27-33, 1996.
17. U Herz, N Schnoy, S Borelli, L Weigl, U Kasbohrer, A Daser, U Wahn, R Kottgen, H Renz. A hu-SCID mouse model for allergic immune responses: bacterial superantigen enhances skin inflammation and supresses IgE production. J Invest Dermatol110:224-231, 1998.
18. DYM Leung, R Harbeck, P Bina, JM Hanifin, RF Reiser, HA Sampson. Presence of IgE antibodies to staphylococcal exotoxins in the skin of patients with atopic dermatitis: evidence for a new group of allergens. J Clin Invest 92:1374-1380, 1993.
19. DYM Leung, M Gately, A Trumble, B Ferguson-Darnell, PM Schlievert, LJ Picker.Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. J Exp Med 181:747-753, 1995.
20. K Kang, M Kubin, KD Cooper, SR Lessin, G Trinchieri, AH Rook. IL-12 synthesis by human Langerhans cells. J Immunol 156:1402-1407, 1996.
21. Y-C Lim, L Henault, AJ Wagers, GS Kansas, FW Luscinskas, AH Lichtman. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J Immunol 162:3193-3201, 1999.
22. DYM Leung, RS Cotran, JS Pober. Expression of an endothelial leukocyte adhesion molecule (ELAM-1) in elicited late phase allergic skin reactions. J Clin Invest 87: 1805-1810, 1991.
23. DYM Leung. Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol 105:860-876, 2000.
24. Q Hamid, M Boguniewicz, DYM Leung. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest 94:870-876, 1994.
25. M Grewe, CAFM Bruijnzeel-Koomen, E Schöpf, T Thepen, AG Langeveld-Wildschut, T Ruzicka, J Krutmann. A role for Th1 and Th2 cells in the immunopa-thogenesis of atopic dermatitis. Immunol Today 19:359-361, 1998.
26. T Thepen, EG Langeveld-Wildschut, IC Bihari, DF van Wichen, FC Van Reijsen, GC Mudde, CAFM Bruijnzeel-Koomen. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial Th2 response to a Th1 response in situ: an immunochemical study. J Allergy Clin Immunol 97:828-837, 1996.
27. M Grewe, W Czech, A Morita, T Werfel, M Klammer, A Kapp, T Ruzicka, E Schöpf, J Krutmann. Human eosinophils produce biologically active IL-12: implications for control of T cell responses. J Immunol 161:415-420, 1998.
28. G Müller, J Saloga, T Germann, I Bellinghausen, M Mohamadzadeh, J Knop, AH Enk. Identification and induction of human keratinoctye-derived IL-12. J Clin Invest94:1799-1805, 1994.
29. S Stoll, H Jonuleit, E Schmitt, G Muller, H Yamauchi, M Kurimoto, J Knop, AH Enk. Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development. Eur J Immunol 28:3231-3239, 1998.
30. + T cells expressing activation, adhesion and co-stimulatory molecules. Eur J Immunol 30:491-497, 2000.
31. MR Kehry, LC Yamashita. Low-affinity IgE receptor (CD23) function on mouse B cells: role in IgE-dependent antigen focusing. Proc Natl Acad Sci USA 86:7556-7560, 1989.
32. G Stigl, D Maurer. IgE-mediated allergen presentation via Fc epsilon RI on antigen-presenting cells. Int Arch Allergy Immunol 113:24-29, 1997.
33. J-P Kinet. Atopic allergy and other hypersensitivities. Curr Opin Immunol 11:603-605, 1999.
34. D Maurer, G Stigl. Immunoglobulin E-binding structures on antigen-presenting cells present in skin and blood. J Invest Dermatol 104:707-710, 1995.
35. FL Van der Heijden, RJJ van Neerven, M van Katwijk, JD Bos, ML Kapsenberg. Serum IgE-facilitated allergen presentation in allergic disease. J Immunol 150:3643-3647, 1993.
36. D Maurer, C Ebner, B Reininger, E Fiebiger, D Kraft, JP Kinet, G Stingl. The high affinity IgE receptor (FceRI) mediates IgE-dependent allergen presentation. J Immunol 154:6285-6289, 1995.
37. U Pirron, T Schlunck, JC Prinz, EP Rieber. IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE. Eur J Immunol20:1547-1551, 1990.
38. LF Santamaria, R Bheekha, FC Van Reijsen, MT Perez Soler, M Suter, CAFM Bruijnzeel-Koomen, GC Mudde. Antigen focusing by specific monomeric immunoglobulin E bound to CD23 on Epstein-Barr virus-transformed B cells. Human Immunol 37:23-30, 1993.
39. RJJ van Neerven, T Wikborg, G Lund, B Jacobsen, A Brinch-Nielsen, J Arnved, H Ipsen. Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum IgE- facilitated allergen presentation. J Immunol 163:2944-2952, 1999.
40. G Achatz, L Nitschke, MC Lamers. Effect of transmembrane and cytoplasmic domains of IgE on the IgE response. Science 276:409-411, 1977.
41. JV Fahy, HE Fleming, HH Wong, JT Liu, JQ Su, J Reinmann, RB Fick, HA Boushey. The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects. Am J Respir Crit Care Med155:1828-1833, 1997.
42. AJ Coyle, K Wagner, C Bertrand, S Tsuyuki, J Bews, C Heusser. Central role of immunoglobulin-E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody. J Exp Med 183:1303-1308, 1996.
43. C Heusser, P Jardieu. Therapeutic potential of anti-IgE antibodies. Curr Opin Immunol 9:805-814, 1997.
44. JM Spergel, E Mizoguchi, H Oettgen, AK Bhan, RS Geha. Roles of Th1 and Th2 cytokines in a murine model of allergic dermatitis. J Clin Invest 103:1103-1111, 1999.
45. LJ Picker, SA Michie, LS Rott, EC Butcher. A Unique phenotype of skin associated lymphocytes in humans: preferential expression of the HECA-452 epitope by benign and malignant T-cells at cutaneous sites. Am J Pathol 136:1053-1061, 1990.
46. LJ Picker, TK Kishimoto, CW Smith, RA Warnock, EC Butcher. ELAM-1 is an adhesion molecule for skin homing T cells. Nature 349:796-799, 1991.
47. LF Santamaria Babi, R Moser, MT Perez Soler, LJ Picker, K Blaser, C Hauser. The migration of skin- homing T cells across cytokine-activated human endothelial cell layers involves interaction of the cutaneous lymphocyte-associated antigen (CLA), the very late antigen-4 (VLA-4) and the lymphocyte function-associated antigen-1 (LFA-1). J Immunol 154:1543-1550, 1995.
48. RC Fuhlbrigge, JD Kieffer, D Armerding, TS Kupper. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin homing T cells. Nature 389: 978-981, 1997.
49. RN Knibbs. The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells. J Cell Biol 133:445-456, 1996.
50. F Austrup, D Vestweber, ELohning Borges, M, R Brauer, U Herz, H Renz, R Hallmann, A Scheffold, A Radbruch, A Hamann. P- and E-selectin mediate recruitment of T helper 1 but not of T helper 2 cells into inflamed tissues. Nature 385:81-84, 1997.
51. AJ Wagers, CM Waters, LM Stoolman, GS Kansas. Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on a1, 3-fucosyltransferase VII gene expression. J Exp Med 188:2225-2231, 1998.
52. JM Blander, I Visintin, CA Janeway Jr., R Medzhitov. a(1,3)-Fucosyltrasferase VII and a(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites. J Immunol 163:3746-3752, 1999.
53. + Th2 cells. Eur J Immunol30:3533-3541, 2000.
54. J Grewe, K Gyufko, K Schopf, J Krutmann. Lesional expression of interferon-Y in atopic eczema. Lancet 343:25-26, 1994.
55. Q Hamid, T Naseer, EM Minshall, YL Song, M Boguniewicz, DYM Leung. In vivo expression of IL-12 and IL-13 in atopic dermatitis. J Allergy Clin Immunol 98:225-231, 1996.
56. J Morales, B Horney, AP Vicari, S Hudak, E Oldham, J Hedrick, R Orosco, NG Copeland, NA Jenkins, L McEvoy, A Zlotnik. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc Natl Acad Sci USA96:14470-14475, 1999.
57. B Horney, W Wang, H Soto, ME Buchanan, A Wiesenborn, D Catron, A Muller, TK McClanahan, M-C Dieu-Nosjean, R Orozco, T Ruzicka, P Lehmann, E Oldham, A Zlotnik. The orphan chemokine receptor G protein-coupled receptor-2 (CRP-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J Immunol 164:3465-3470, 2000.
58. C Vestergaard, H Yoneyama, M Murai, K Nakamura, K Tamaki, Y Terashima, T Imai, O Yoshie, T Irimura, H Mizutani, K Matsushima. Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions. J Clin Invest 104:1097-1105, 1999.
59. N Yawalkar, M Uguccioni, J Scharer, J Braunwalder, S Karlen, B Dewald, LR Braathen, M Baggiolini. Enhanced expression of eotaxin and CCR3 in atopic dermatitis. J Invest Dermatol 113:43-48, 1999.
60. + T cell infiltration with increased IL-16 gene expression in atopic dermatitis. J Allergy Clin Immunol 102:645-650, 1998.
61. LF Santamaria Babi, B Moser, MT Perez Soler, R Moser, P Loetscher, B Villiger, K Blaser, C Hauser. The interleukin-8 receptor B and CXC chemokines can mediate transendothelial migration of human skin homing T cells. Eur J Immunol 26:2056-2061, 1996.
62. JM Hanifin, G Rajka. Diagnostic features of atopic dermatitis. Acta Derm Venerol92:44-47, 1980.
63. B Wuthrich. Serum IgE in atopic dermatitis. Clin Allergy 8:241-248, 1978.
64. H-U Simon, K Blaser. Inhibition of programmed eosinophil death: A key pathogenic event for eosinophilia. Immunol Today 16:53-55, 1995.
65. C Scaffidi, S Kirchhof, PH Krammer, ME Peter. Apoptosis signaling in lymphocytes. Curr Opin Immunol 11:277-285, 1999.
66. CB Thompson. Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462, 1995.
67. DR Green, DW Scott. Activation-induced apoptosis in lymphocytes. Curr Opin Immunol 6:476-487, 1994.
68. J Dhein, H Walczak, C Baumler, KM Debatin, PH Krammer. Autocrine T-cell suicide mediated by APO-1(Fas/CD95). Nature 373:438-441, 1995.
69. T Brunner, RJ Mogil, D LaFace, N Jin Yoo, A Mahboubi, F Echeverri, SJ Martin, WR Force, DH Lynch, CF Ware, DR Green. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373:441-444, 1995.
70. J Shyr-Te, DJ Panka, H Cui, R Ettinger, M El-Khatib, DH Sherr, BZ Stanger, A Marshak-Rothstein. Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373:444-448, 1995.
71. M Akdis, A Trautmann, K Blaser, CA Akdis. Life span of skin homing T cells in atopic dermatitis: survival in skin, activation induced apoptosis in peripheral blood. J Allergy Clin Immunol 105:167, 2000.
72. E Rouslahti, MD Pierschbacher. New perspectives in cell adhesion: RDG and inte-grins. Science 238:491-497, 1987.
73. EA Clöark, SJ Brugge. Integrins and signal transduction pathways: the road taken. Science 268:233-238, 1995.
74. KK Wary, F Mainiero, SJ Isakoff, EE Marcantonio, FG Giancotti. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell87:733-743, 1996.
75. GE Hanningan, C Leung-Hagesteijn, L Fitz-Gibbon, MG Coppolino, G Radeva, J Filmus, JC Bell, S Dedhar. Regulation of cell adhesion and anchorage-dependent growth by a new P1-integrin-linked protein kinase. Nature 379:91-96, 1996.
76. SM Frisch, K Vuori, E Rouslahti, PY Chan-Hui. Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 134:793-799, 1996.
77. A Khwaja, P Rodriguez-Viciana, S Wennstrom, P Warne, J Downward. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J 16:2783-2793, 1997.
78. JG Giri, S Kumaki, M Ahdieh, DJ Friend, A Loomis, K Shanebeck, R Dubose, D Cosman, LS Park, DM Anderson. Identification and cloning of a novel IL-15 binding protein that is structurally related to the a chain of the IL-2 receptor. EMBO J 14: 3654-3663, 1995.
79. WC Li, A Ima, Y Li, XX Zheng, TR Malek, TB Strom. Blocking the common g-chain of cytokine receptors induces T cell apoptosis and long term islet allograft survival. J Immunol 164:1193-1199, 2000.
80. A Trautmann, M Akdis, D Kleeman, F Altznauer, H-U Simon, T Graeve, M Noll, K Blaser, CA Akdis. T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. J Clin Invest 106:25-35, 2000.
81. + T cell subsets against keratinocytes. J Immunol 165:3058-3064, 2000.
82. B Schnyder, K Frutig, D Mauri-Hellweg, A Limat, N Yawalkar, WJ Pichler. T-cell mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reactions. Clin Exp Allergy 28:1412-1417, 1998.
83. JM Carroll, T Crompton, JP Seery, FM Watt. Transgenic mice expressing IFN-γ in the epidermis have eczema, hair hypopigmentation and hair loss. J Invest Dermatol108:412-422, 1997.