Human eosinophils produce biologically active IL-12: Implications for control of T cell responses

Journal of Immunology

Volumn 161, Issue 1, 1998, Pages 415-420

  Grewe, Markus ^a   Czech, Wolfgang ^b   Morita, Akimichi ^a   Werfel, Thomas ^c   Klammer, Michaela ^a   Kapp, Alexander ^c   Ruzicka, Thomas ^a   Schöpf, Erwin ^b   Krutmann, Jean ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12;

ARTICLE; CELL CULTURE; CELL ISOLATION; CELLULAR IMMUNITY; COLONY FORMING UNIT GM; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EOSINOPHIL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CELL LINE; CELL-FREE SYSTEM; ENZYME-LINKED IMMUNOSORBENT ASSAY; EOSINOPHILS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; RNA, MESSENGER; TH1 CELLS;

EID: 0031830895     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Butterworth, A. E. 1984. Cell-mediated damage to helminths. Adv. Parasitol. 23:143.
2. Gleich, G. J., and C. R. Adolphson. 1986. The eosinophil leukocyte: structure and function. Adv. Immunol. 39:177.
3. Wardlaw, A. J., and A. B. Kay. 1987. The role of the eosinophil in the pathogenesis of asthma. Allergy 42:321.
4. Proost, P., A. Wuyts, and J. van Damme. 1996. The role of chemokines in inflammation. Int. J. Clin. Lab. Res. 26:211.
5. Baggiolini, M., B. Dewald, and B. Moser. 1997. Human chemokines: an update. Annu. Rev. Immunol. 15:675.
6. Silberstein, D. S., W. F. Owen, J. C. Gasson, J. F. DiPersio, D. W. Golde, J. C. Bina, R. Soberman, K. F. Austen, and J. R. David. 1986. Enhancement of human eosinophil cytotoxicity and leukotriene synthesis by biosynthetic (recombinant) granulocyte-macrophage CSF. J. Immunol. 137:3290.
7. Owen, W. F., M. E. Rothenburg, D. S. Silberstein, J. C. Gasson, R. L. Stevens, K. F. Austen, and R. J. Soberman. 1987. Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts. J. Exp. Med. 166:129.
8. Rothenburg, M. F., J. Petersen, R. L. Stevens, D. S. Silberstein, D. T. McKenzie, K. F. Austen, and W. F. Owen. 1989. IL-5-dependent conversion of normodense human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody-dependent cytotoxicity. J. Immunol. 143:2311.
9. Rothenburg, M. E., W. F. Owen, D. S. Silberstein, J. Woods, R. J. Soberman, K. F. Austen, and R. L. Stevens. 1988. Human eosinophils have prolonged survival, enhanced functional properties and become hypodense when exposed to human interleukin-3. J. Clin. Invest. 81:1986.
10. Her, E., J. Frazer, K. F. Austen, and W. F. Owen. 1991. Eosinophil hematopoietins antagonize the programmed cell death of human eosinophils: cytokine and glucocorticoid effects on eosinophils maintained by endothelial cell-conditioned medium. J. Clin. Invest. 88:1982.
11. Schleimer, R. P., S. A. Sterbinsky, J. Kaiser, C. A. Bickel, D. A. Klunk, K. Tomioka, W. Newman, F. W. Luscinskas, M. A. Gimbrone, B. W. McIntyre, and B. S. Bochner. 1992. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium: association with expression of VCAM-1. J. Immunol. 148:1086.
12. Hirai, K., M. Miyamasu, T. Takaishi, and Y. Morita. 1997. Regulation of the function of eosinophils and basophils. Crit. Rev. Immunol. 17:325.
13. Ackerman, S. J. 1993. Characterization and functions of eosinophil granule proteins. In Eosinophils: Biological and Clinical Aspects. S. Makino, and T. Fukuda, eds. CRC Press, Boca Raton, pp. 33-74.
14. Elsner, J., M. Oppermann, W. Czech, G. Dobos, E. Schöpf, J. Norgauer, and A. Kapp. 1994. C3a activates reactive oxygen radical species production and intracellular calcium transients in human eosinophils. Eur. J. Immunol. 24:518.
15. Shult, P. A., F. M. Graziano, and W. W. Busse. 1985. Enhanced eosinophil luminol-dependent chemiluminescence in allergic rhinitis. J. Allergy Clin. Immunol. 77:702.
16. Moqbel, R., S. Ying, J. Barkans, T. M. Newman, P. Kimmit, M. Wakelin, L. Taborda-Barata, Q. Meng, C. J. Corrigan, S. R. Durham, and A. B. Kay. 1995. Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product. J. Immunol. 155:4939.
17. Dubucquoi, S., P. Desreumaux, A. Janin, O. Klein, M. Goldman, J. Tavernier, A. Capron, and M. Capron. 1994. Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion. J. Exp. Med. 179:703.
18. Wynn, T. A., I. P. Oswald, I. A. Eltoum, P. Caspar, C. J. Lowenstein, F. A. Lewis, S. L. James, and A. Sher. 1994. Elevated expression of Th1 cytokines and nitric oxide synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni. J. Immunol. 153:5200.
19. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151.
20. Grewe, M., K. Gyufko, E. Schöpf, and J. Krutmann. 1994. Lesional expression of interferon-γ in atopic eczema. Lancet 343:25.
21. Ohmen, J. D., J. M. Hanifin, B. J. Nickoloff, T. H. Rea, R. Wyzykowski, J. Kim, D. Jullien, T. McHugh, A. S. Nassif, S. C. Chan, and R. L. Modlin. 1995. Over-expression of IL-10 in atopic dermatitis: contrasting cytokine patterns with delayed-type hypersensitivity reactions. J. Immunol. 154:1956.
22. Werfel, T., A. Morita, M. Grewe, H. Renz, U. Wahn, J. Krutmann, and A. Kapp. 1996. Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis. J. Invest. Dermatol. 107:871.
23. Brunda, M. J. Interleukin-12. 1994. J. Leukocyte Biol. 55:280.
24. Germann, T., and E. Rude. 1995. Interleukin-12. Int. Arch. Allergy Immunol. 108:103.
25. Butterworth, A. E., R. F. Sturrock, V. Houba, and P. H. Rees. 1974. Antibody-dependent cell-mediated damage to schistosomula in vitro. Nature 252:503.
26. Butterworth, A. E., R. F. Sturrock, V. Houba, A. A. Mahmoud, A. Sher, and P. H. Rees. 1975. Eosinophils as mediators of antibody-dependent damage to schistosomula. Nature 256:727.
27. Bruynzeel-Koomen, C. A. F. M., D. F. van Wichen, C. J. F. Spry, P. Venge, P. L. B. Bruynzeel. 1988. Active participation of eosinophils in patch test reactions to inhalant allergens in patients with atopic dermatitis. Br. J. Dermatol. 118:229.
28. Kapp, A., M. Danner, T. A. Luger, C. Hauser, and E. Schöpf. 1987. Granulocyte-activating mediators (GRAM): generation by human epidermal cells. Arch. Dermatol. Res. 279:470.
29. Hansel, T. T., J. D. Pound, D. Pilling, G. D. Kitas, M. Salmon, T. A. Gentle, S. S. Lee, and R. A. Thompson. 1989. Purification of human blood eosinophils by negative selection using immunomagnetic beads. J. Immunol. Methods 122:97.
30. Kimura, I., Y. Moritani, and Y. Tanizaki. 1973. Basophils in bronchial asthma with reference to reagin-type allergy. Clin. Allergy 3:195.
31. Peters, M., G. J. Gleich, S. L. Dunnette, and T. Fukuda. 1988. Ultrastructural study of eosinophils from patients with hypereosinophilic syndrome: a morphological basis of hypodense eosinophils. Blood 71:780.
32. Yukawa, T., C. Kroegel, T. Fukuda, K. F. Chung, and P. J. Barnes. 1989. Density heterogeneity of eosinophil leukocytes: induction of hypodense eosinophils by platelet-activating factor. Immunology 68:140.
33. Krutmann, J., I. U. Khan, R. S. Wallis, F. Zhang, E. A. Rich, J. J. Ellner, and C. A. Elmets. 1990. Cell membrane is a major locus for ultraviolet B-induced alterations in accessory cells. J. Clin. Invest. 85:1529.
34. Chomzynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
35. Henninger, H. P., R. Hoffmann, M. Grewe, A. Schulze-Specking, and K. Decker. 1993. Purification and quantitative analysis of nucleic acids by anion-exchange-high-performance liquid chromatography. Biochem. Biophys. Hoppe-Seyler 374: 625.
36. Grewe, M., K. Gyufko, A. Budnik, T. Ruzicka, S. Olaizola-Horn, M. Berneburg, and J. Krutmann. 1996. Interleukin-1 receptors type 1 and type II are differentially regulated in human keratinocytes by ultraviolet B radiation. J. Invest. Dermatol. 107:865.
37. Muller, G., J. Saloga, T. Germann, I. Bellinghausen, M. Mohamadzadeh, J. Knop, and A. H. Enk. 1994. Identification and induction of human keratinocyte-derived IL-12. J. Clin. Invest. 94:1799.
38. Yousefi, S., S. Hemmann, M. Weber, C. Hölzer, K. Hartung, K. Blaser, and H.-U. Simon. 1995. IL-8 is expressed by human peripheral blood eosinophils: evidence for increased secretion in asthma. J. Immunol. 154:5481.
39. Grewe, M., S. Walther, K. Gyufko, W. Czech, E. Schöpf, and J. Krutmann. 1995. Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients. J. Invest. Dermatol. 105:407.
40. Thepen, T., E. G. Langeveld-Wildschut, I. C. Bihari, D. F. van Wichen, F. C. van Reijsen, G. C. Mudde, and C. A. F. M. Bruijnzeel-Koomen. 1996. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial Th2 response in situ: an immunocytochemical study. J. Allergy Clin. Immunol. 97:828.
41. Tripp, C. S., S. F. Wolf, and E. R. Unanue. 1993. Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90:3725.
42. Gazzinelli, R. T., M. Wysocka, S. Hayashi, E. Y. Denkers, S. Hieny, P. Caspar, G. Trinchieri, and A. Sher. 1994. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol. 153:2533.
43. Gazzinelli, R. T., S. Hayashi, M. Wysocka, L. Carrera, R. Kuhn, W. Muller, F. Roberge, G. Trinchieri, and A. Sher. 1994. Role of IL-12 in the initiation of cell-mediated immunity by Toxoplasma gondii and its regulation by IL-10 and nitric oxide. J. Eukaryot. Microbiol. 41:9.