Human afferent lymph from normal skin contains an increased number of mainly memory/effector CD4+ T cells expressing activation, adhesion and co-stimulatory molecules

European Journal of Immunology

Volumn 30, Issue 2, 2000, Pages 491-497

  Yawalkar, Nikhil ^a,b   Hunger, Robert E ^a   Pichler, Werner J ^a   Braathen, Lasse R ^a   Brand, Christoph U ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Cytokine; Dendritic cell; Skin derived lymph; T cell

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; CD69 ANTIGEN; CELL ADHESION MOLECULE; CYTOKINE; DIPEPTIDYL PEPTIDASE IV; GAMMA INTERFERON; GLYCOPROTEIN GP 39; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 5; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ARTICLE; BLOOD; CELL ADHESION; DENDRITIC CELL; EFFECTOR CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOSURVEILLANCE; LYMPH; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; NORMAL HUMAN; PRIORITY JOURNAL; SKIN; TH1 CELL;

ANTIGENS, CD; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION MOLECULES; HUMANS; IMMUNOLOGIC MEMORY; INTERLEUKINS; LYMPH; LYMPHOCYTE ACTIVATION; SKIN PHYSIOLOGY;

EID: 0033952595     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200002)30:2<491::AID-IMMU491>3.0.CO;2-H     Document Type: Article

References (24)

1. Butcher, E. C. and Picker, L. J., Lymphocyte homing and homeostasis. Science 1996. 272: 60-66.
2. Mackay, C. R., Marston, W. L. and Dudler, L., Naive and memory T cells show distinct pathways of lymphocyte recirculation. J. Exp. Med. 1990. 171: 801-817.
3. Smith, J. B., McIntosh, G. H. and Morris, B., The traffic of cells through tissues: a study of peripheral lymph in sheep. J. Anat. 1970. 107: 87-100.
4. Abitorabi, M. A., Mackay, C. R., Jerome, E. H., Osorio, O., Butcher, E. C. and Erle, D. J., Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph. J. Immunol. 1996. 156: 3111-3117.
5. Sokolowski, J., Jakobsen, E. and Johannessen, J. V., Cells in peripheral leg lymph of normal men. Lymphology 1978. 11: 202-207.
6. Oszewski, W. L., Gzelak, I., Ziolkowska, A. and Engeset, A., Immune cell trafic from blood through the normal human skin to lymphatics. Clin. Dermatol. 1995. 13: 473-483.
7. Brand, C. U., Hunziker, T. and Braathen, L. R., Isolation of human skin-derived lymph: flow and output of cells following sodium lauryl sulphate-induced contact dermatitis. Arch. Dermatol. Res. 1992. 284: 123-126.
8. Brand, C. U., Hunger, R. E., Yawalkar, N., Gerber, H. A., Schaffner, T. and Braathen, L. R., Characterization of human Skin-derived CD1a positive lymph cells. Arch. Dermatol. Res. 1999. 291: 65-72.
9. + dendritic lymph cells. Arch. Dermatol. Res. 1996. 288: 79-84.
10. Bos, J. D., Zonneveld, I., Das, P. K., Krieg, S. R, van der Loos, C. M. and Kapsenberg, M. L., The skin immune system (SIS): distribution and immunophenotype of lymphocyte subpopulations in normal human skin. J. Invest. Dermatol. 1987. 88: 569-573.
11. Hunger, R. E., Yawalkar, N., Braathen, L. R. and Brand, C. U., The HECA-452 epitope is highly expressed on human skin derived lymph cells. Br. J. Dermatol. 1999. 141: 565-569.
12. + T cells contain cells with high levels of lymphocyte function-associated antigen-1 expression, a phenotype of primed cells. J. Immunol. 1993. 150: 429-437.
13. + T cells. J. Exp. Med. 1997. 186: 1407-1418.
14. Banchereau, J., Bazan, F., Blanchard, D., Briere, F., Galizzi, J. P., van Kooten, C., Liu, Y. J., Rousset, F. and Saeland, S., The CD40 antigen and its ligand. Annu. Rev. Immunol. 1994. 12: 881-922.
15. Cella, M., Scheidegger, D., Palmer Lehmann, K., Lane, P., Lanzavecchia, A. and Alber, G., Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhanced T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 1996. 184: 747-752.
16. Ma, X., Aste-Amezage, M., Gri, G., Gerosa, F. and Trinchieri, G., Immunomodulatory functions and molecular regulation of IL-12. In Adorini, L. (Ed.) IL-12 Chem. Immunol. Karger, Basel, 1997. Vol. 68, pp1-22.
17. McDyer, J. F., Goletz, T. J., Thomas, E., June, C. H. and Seder, R. A., CD40 ligand/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and/or CD28-dependent manner. J. Immunol. 1998. 160: 1701-1707.
18. Seitzer, U., Scheel-Toellner, D., Hahn, M., Heinemann, G., Mattern, T., Flad, H. D. and Gerdes, J., Comparative study of CD26 as a Th1-like and CD30 as a potential Th2-like operational marker in leprosy. Adv. Exp. Med. Biol. 1997. 421: 217-221.
19. Bonecchi, R., Bianchi, G., Bordignon, P. P., D'Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S., Allavena, P., Gray, P. A., Mantovani, A. and Sinigaglia, F., Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J. Exp. Med. 1998. 187: 129-134.
20. Ottenhoff, T. H. M., Kumararatne, D. and Casanova, J. L., Novel human immunodeficiencies reveal the essential role of type-1 cytokines in immunity to intracellular bacteria. Immunol. Today 1998. 19: 491-494.
21. Mebius, R. E., Dowbenko, D., Williams, A., Fennie, C., Lasky, L. A. and Watson, S. R., Expression of GlyCAM-1, an endothelial ligand for L-selectin, is affected by afferent lymphatic flow. J. Immunol. 1993. 151: 6769-6776.
22. Duijvestijn, A. M., Schreiber, A. B. and Butcher, E. C., Interferon-gamma regulates an antigen specific for endothelial cells involved in lymphocyte traffic. Proc. Natl. Acad. Sci. USA 1986. 83: 9114-9118.
23. Zanni, M. P., Mauri-Hellweg, D., Brander, C., Wendland, T., Schnyder B., Frei, E., von Greyerz, S., Bircher, A. and Pichler, W. J., Characterization of lidocaine-specific T cells. J. Immunol. 1997. 158: 1139-1148.
24. Yawalkar, N., Egli, F., Brand, C. U., Pichler, W. J. and Braathen, L. R., Antigen-presenting cells and keratinocytes express Interleukin 12 in allergic contact dermatitis. Contact dermatitis (in press).