T cells and T cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis

Journal of Investigative Dermatology

Volumn 113, Issue 4, 1999, Pages 628-634

  Akdis, Cezmi A ^a   Akdis, Mübeccel ^a   Simon, Dagmar ^b   Dibbert, Birgit ^a   Weber, Martina ^a   Gratzl, Stephanie ^a   Kreyden, Oliver ^c,d   Disch, Rainer ^b   Wüthrich, Brunello ^d   Blaser, Kurt ^a   Simon, Hans Uwe ^a  

^a SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

^b Clin for Dermatol and Allerg   (Switzerland)

^c High Altitude Clinic Davos Wolfgang   (Switzerland)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Atopic dermatitis; Cytokines; Immunoglobulin E; Superantigen; T cells

Indexed keywords

CD23 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 5;

ANTIGEN EXPRESSION; ARTICLE; ATOPIC DERMATITIS; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LYMPHOCYTE ACTIVATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SKIN BIOPSY; T LYMPHOCYTE SUBPOPULATION;

EID: 0032869237     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1999.00720.x     Document Type: Article

References (50)

1. Abernathy-Carver KJ, Sampson HA, Picker LJ, Leung DYM: Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen. J Clin Invest 95:913-918, 1995
2. Agner T: Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. Acta Derm Venereol (Stockh) 71:296-300, 1991
3. 2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro. J Clin Invest 98:1676-1683, 1996
4. - memory T cells. J Immunol 159:4611-4619, 1997
5. Akdis CA, Blesken T, Akdis M, Wüthrich B, Blaser K: The role of IL-10 in specific immunotherapy. J Clin Invest 102:98-106, 1998
6. + T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis. J Immunol 163:466-475, 1999
7. Aman MJ, Tayebi N, Obiri NI, Puri RK, Modi WS, Leonard WJ: cDNA cloning and characterization of the human interleukin 13 receptor alpha chain. J Biol Chem 271:29265-29270, 1996
8. Bousquet J, Chanez P, Lacoste JY, et al: Eosinophilic inflammation in asthma. N Engl J Med 323:1033-1039, 1990
9. + T cell profile from Th2-dominant type to Th1-dominant type after varicella-zoster virus infection in atopic dermatitis. J Allergy Clin Immunol 100:274-282, 1997
10. Grünig G, Warnock M, Wakil AE, et al: Requirement of IL-13 independently of IL-4 in experimental asthma. Science 282:2261-2263, 1998
11. Hamid Q, Boguniewicz M, Leung DYM: Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest 94:870-876, 1994
12. Hanifin JM, Rajka G: Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 92:44-47, 1980
13. Herz U, Schnoy N, Borelli S, et al: A hu-SCID mouse model for allergic immune responses: Bacterial superantigen enhances skin inflammation and suppresses IgE production. J Invest Dermatol 110:224-231, 1998
14. Jujo K, Renz H, Abe J, Gelfand EW, Leung DYM: Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis. J Allergy Clin Inmunol 90:323-331, 1992
15. + T cells: modulation by interleukin-4 and interleukin-12. Eur J Immunol 26:571-577, 1996
16. Kägi MK, Wüthrich B, Montano E, Barandun J, Blaser K, Walker C: Differential cytokine profiles in peripheral blood supernatants and skin biopsies from patients with different forms of atopic dermatitis, psoriasis and normal individuals. Int Arch Allergy Immunol 103:332-340, 1994
17. Kapp A, Piskorski A, Schöpf E: Elevated levels of interleukin 2 receptor in sera of patients with atopic dermatitis. Br J Dermatol 119:707-710, 1988
18. Koblenzer C: Stress and the skin: psychosomatic concepts in dermatology. Arch Dermatol 119:501-512, 1983
19. Kotzin BL, Leung DYM, Kappler J, Marrack P: Superantigens and human disease. Adv Immunol 54:99-166, 1993
20. Le Gros G, Ben Sason SZ, Seder R, Finkelman FD, Paul WE: Generation of IL-4 producing cells in vivo and in vitro: IL-2 and IL-4 are required for the in vitro generation of IL-4 producing cells. J Exp Med 172:921-929, 1990
21. Leung DYM, Gately M, Trumble A, Ferguson-Darnell B, Schlievert PM, Picker LJ: Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. J Exp Med 181:747-753, 1995
22. Leyden JE, Marpies RR, Kligman AM: Staphylococcus aureus in the lesions of atopic dermatitis. Br J Dermatol 90:525-530, 1974
23. Morren MA, Przybilla B, Bamelis M, Heykants B, Reynaers A, Degreef H: Atopic dermatitis: triggering factors. J Am Acad Dermatol 31:467-473, 1994
24. + cells in patients with atopic dermatitis. J Allergy Clin Immunol 99:673-682, 1997
25. Oehling AG, Akdis CA, Schapowal A, Blaser K, Schmitz M, Simon H-U: Suppression of the immune system by oral glucocorticoid therapy in bronchial asthma. Allergy 52:144-152, 1997
26. Picker LJ, Michie SA, Rott LS, Butcher EC: A Unique phenotype of skin associated lymphocytes in humans: preferential expression of the HECA-452 epitope by benign and malignant T-cells at cutaneous sites. Am J Pathol 136:1053-1061, 1990
27. Picker LJ, Kishimoto TK, Smith CW, Warnock RA, Butcher EC: ELAM-1 is an adhesion molecule for skin homing T cells. Nature 349:796-799, 1991
28. Punnonen J, Aversa G, Cocks BG, et al: Interleukin 13 induces interleukin 4 independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 90:3730-3734, 1993
29. Reinhold U. T cell mediated immunoregulation in atopic dermatitis. In: Wüthrich B (ed.). Highlights in Allergy and Clinical Immunology. Seattle: Hogrefe and Huber, 1992, p 3
30. Rousset F, Robert J, Andary M, et al: Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis. J Allergy Clin Immunol 87:58-69, 1991
31. Rudikoff D, Lebwohl M: Atopic dermatitis. Lancet 351:1715-1721, 1998
32. Ruzicka T, Bieber T, Schöpf E, et al: A short-term trial of tacrolimus ointment for atopic dermatitis. N Engl J Med 337:816-821, 1997
33. Sager N, Feldmann A, Schilling G, Kreitsch P, Neumann C: House dust-mite specific T cells in the skin of subjects with atopic dermatitis: frequency and lymphokine profile in the allergen patch test. J Allergy Clin Immunol 89:801-810, 1992
34. Simon H-U, Yousefi S, Schranz C, Schapowal A, Bachert C, Blaser K: Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol 158:3902-3908, 1997
35. Strange P, Skov L, Lisby S, Nielsen PL, Baadsgaard O: Staphylococcal enterotoxin B applied on intact normal and intact atopic skin induces dermatitis. Arch Dermatol 132:27-33, 1996
36. Tony HP, Shen BJ, Reusch P, Sebald W: Design of human interleukin-4 antagonists inhibiting interleukin-4 dependent and interleukin-13 dependent responses in T-cells and B-cells with high efficiency. Eur J Biochem 225:659-665, 1994
37. + allergen-specific T lymphocytes in atopic dermatitis lesional skin. J Invest Dermatol 97:389-394, 1991
38. Van der Pouw-Kraan TC, Aalberse RC, Aarden LA: IgE production in atopic patients is not related to IL-4 production. Clin Exp Immunol 97:254-259, 1994
39. Van Reijsen FC, Bruijnzeel-Komen CAFM, Kalthoff FS, Maggi E, Romagnani S, Westland JKT, Mudde GC: Skin-derived aero-allergen specific T cell clones of Th2 phenotype in patients with atopic dermatitis. J Allergy Clin Immunol 90:184-193, 1992
40. Varney VA, Hamid QA, Gaga M, et al: Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late phase cutaneous responses. J Clin Invest 92:644-651, 1993
41. Walker C, Kägi MK, Ingold P, Braun P, Blaser K, Bruijnzeel-Koomen CAFM, Wüthrich B: Atopic dermatitis: correlation of peripheral blood T cell activation, eosinophilia and serum factors with clinical severity. Clin Exp Allergy 23:145-153, 1993
42. Wedi B, Raap U, Lewrick H, Kapp A: Delayed eosinophil programmed cell death in vitro: a common feature of inhalant allergy and extrinsic or intrinsic atopic dermatitis. J Allergy Clin Immunol 100:536-543, 1997
43. Werfel T, Morita A, Grewe M, Renz H, Wahn U, Krutmann J, Kapp A: Allergen-specificity of skin-infiltrating T-cells is not restricted to a type 2 cytokine pattern in chronic skin lesions of atopic dermatitis. J Invest Dematol 107:871-876, 1996
44. Williams HC, Burney PG, Hay RJ, et al: The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis. Br J Dermatol 131:383-396, 1994
45. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp KL, Donaldson DD: Interleukin 13: Central mediator of allergic asthma. Science 282:2258-2261, 1998
46. Wüthrich B: Serum IgE in atopic dermatitis. Clin Allergy 8:241-248, 1978
47. Wüthrich B: Atopic dermatitis flare provoked by inhalant allergens. Dermatologica 178:51-53, 1989
48. Yousefi S, Hemmann S, Weber M, Hölzer C, Hartung K, Blaser K, Simon H-U: II.-8 is expressed by human peripheral blood eosinophils. Evidence for increased secretion in asthma. J Immunol 154:5481-5490, 1995
49. Zhang X, Polla B, Hauser C, Zubler RH: T cells from atopic individuals produce an IgE inducing activity incompletely blocked by anti-interleukin-4 antibody. Eur J Immunol 22:829-833, 1992
50. Zurawski G, De Vries JE: Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 15:19-26, 1994