Immune regulation in atopic dermatitis

Current Opinion in Immunology

Volumn 12, Issue 6, 2000, Pages 641-646

  Akdis, Cezmi A ^a   Akdis, Mübeccel ^a   Trautmann, Axel ^a   Blaser, Kurt ^a  

^a SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 5;

APOPTOSIS; ATOPIC DERMATITIS; CELL SURVIVAL; ECZEMA; EFFECTOR CELL; EOSINOPHIL; HUMAN; IMMUNOGLOBULIN PRODUCTION; IMMUNOREGULATION; KERATINOCYTE; LYMPHOCYTE HOMING; MEMORY CELL; NONHUMAN; PATHOGENESIS; REVIEW; T LYMPHOCYTE ACTIVATION;

EID: 0033739005     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00156-4     Document Type: Review

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8. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin homing T cells
9. The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells
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12. Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen
13. + memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern. IgG4 counter-regulation by CLA- memory T cells
14. + T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis
15. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells
16. The orphan chemokine receptor G protein-coupled receptor-2 (CRP-2,CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)
17. Enhanced expression of eotaxin and CCR3 in atopic dermatitis
18. + T cell infiltration with increased IL-16 gene expression in atopic dermatitis
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42. Human afferent lymph from normal skin contains an increased number of mainly memory/effector CD4+ T cells expressing activation, adhesion and co-stimulatory molecules
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51. T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis
52. Transgenic mice expressing I FN-γ in the epidermis have eczema, hair hypopigmentation and hair loss