Radiosensitization of hypoxic tumor cells by Dodecafluoropentane: A gas-phase perfluorochemical emulsion

Cancer Research

Volumn 62, Issue 13, 2002, Pages 3626-3629

  Koch, Cameron J ^a   Oprysko, Patricia R ^a   Shuman, A Lee ^a   Jenkins, W Timothy ^a   Brandt, Gordon ^a   Evans, Sydney M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 NITRO 1H IMIDAZOL 1 YL) N (2,2,3,3,3 PENTAFLUOROPROPYL)ACETAMIDE; CARBOGEN; ISOFLURANE; PERFLUORO COMPOUND; PERFLUOROPENTANE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CELL SURVIVAL; CONTROLLED STUDY; EMULSION; FEMALE; HYPOXEMIA; HYPOXIC CELL; MORRIS HEPATOMA; NONHUMAN; OXYGEN BREATHING; PRIORITY JOURNAL; RADIATION RESPONSE; RADIOSENSITIZATION; RAT; TUMOR CELL;

ANIMALS; CELL HYPOXIA; FEMALE; FLUOROCARBONS; LIVER NEOPLASMS, EXPERIMENTAL; OXYGEN; RADIATION-SENSITIZING AGENTS; RATS; RATS, INBRED BUF;

EID: 0036645420     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Oxygenation predicts radiation response and survival in patients with cervix cancer
2. Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
3. Expression of hypoxia-inducible factor-1α: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
4. Prognostic value of vascular endothelial growth factor (VEGF) in head and neck squamous cell carcinomas
5. Relevance of oxygen in radiation oncology. Mechanisms of action, correlation to low hemoglobin levels
6. Oxygen-carrying perfluorochemical emulsion as an adjuvant to radiation therapy in mice
7. Perfluorochemical emulsions and radiation therapy
8. A clinical trial of Fluosol DA 20% in advanced squamous cell carcinoma of the head and neck
9. Oxygen transport to tissue by persistent bubbles: Theory and simulations
10. 2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s. c. tumors
11. Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide]: Analysis of drug adducts by fluorescent antibodies vs. bound radioactivity
12. Radiation response and other characteristics of the 9L rat glioma grown as an epigastric tissue isolate
13. Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and the 2-nitroimidazole EF5
14. Cysteine concentrations in rodent tumors: Unexpectedly high values may cause therapy resistance
15. Induction and transplantation of rat hepatomas with different growth rate (including "minimal deviation" hepatomas)
16. The K(m) for radiosensitization of human tumor cells by oxygen is much greater than 3 mmHg and is further increased by elevated levels of cysteine
17. Prediction of hypoxic radioresistance by monoclonal antibody reactive with 2-nitroimidazole adducts
18. Oxygen diffusion and the distribution of radiosensitivity in tumours
19. Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiation therapy
20. The unusual dependence on oxygen concentration of toxicity by SR-4233 [3-amino-1, 2, 4-benzotriazine-1, 4-dioxide]: An hypoxic cell toxin