Coregulation of glucose uptake and vascular endothelial growth factor (VEGF) in two small-cell lung cancer (SCLC) sublines in vivo and in vitro

Neoplasia

Volumn 3, Issue 1, 2001, Pages 80-87

  Pedersen, Minna W B ^a   Holm, Søren ^a   Lund, Eva L ^a   Højgaard, Liselotte ^a   Kristjansen, Paul E G ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

GLUT 1; HIF 1 ; Hypoxia; Small cell lung cancer; VEGF

Indexed keywords

DEOXYGLUCOSE; HYPOXIA INDUCIBLE FACTOR 1; VASCULOTROPIN;

ARTICLE; GENE EXPRESSION REGULATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; HUMAN; HUMAN CELL; HYPOXIA; LUNG SMALL CELL CANCER; OXYGEN CONSUMPTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TRANSCRIPTION REGULATION; TUMOR XENOGRAFT;

EID: 0035093491     PISSN: 15228002     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.neo.7900133     Document Type: Article

References (36)

1. Growth kinetics and in vivo radiosensitivity in nude mice of two subpopulations derived from a single human small cell carcinoma of the lung
2. Cellular radiosensitivity of small-cell lung cancer cell lines
3. 31P magnetic resonance spectroscopy and biochemical analysis
4. 31P magnetic resonance spectroscopy and biochemical analysis in vivo and in vitro
5. Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer
6. Intratumoral pharmacokinetic analysis by 19-F magnetic resonance spectroscopy and cytostatic in vivo activity of Gemcitabine in two small cell lung cancer xenografts
7. Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 μl resolution
8. Pathophysiology of human tumor xenografts. Aspects of metabolism, physiology, and pharmacokinetics in heterotransplanted human lung and colon tumors
9. Suppression of tumor growth disruption of hypoxia-inducible transcription
10. The ability of hypoxia to modify the gene expression of thymidylate synthase in tumour cells in vivo
11. Direct comparison of GAPDH, beta-actin, cyclophilin, and 28S rRNA as internal standards for quantifying RNA levels under hypoxia
12. Mechanism of stimulation of glucose transport in response to inhibition of oxidative phosphorylation: Analysis with myc-tagged Glut1
13. Over-expression of facilitative glucose transporter genes in human cancer
14. Increases in mRNA levels of glucose transporters types 1 and 3 in Ehrlich ascites tumor cells during tumor development
15. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
16. Accelerated image reconstruction using ordered subsets of projection data
17. Deregulated simultaneous expression of multiple glucose transporter isoforms in malignant cells and tissues
18. Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers
19. Enhanced expression of glucose transporter GLUT3 in tumorigenic HeLa cell hybrids associated with tumor suppressor dysfunction
20. Expression of glucose transporters in human pancreatic tumors compared with increased FDG accumulation in PET study
21. Intratumoral distribution of tritiated-FDG in breast carcinoma: Correlation between Glut-1 expression and FDG uptake
22. Mechanisms related to [F-18] fluorodeoxyglucose uptake of human colon cancers transplanted in nude mice
23. The importance of glucose transport activity as the rate-limiting step of 2-deoxyglucose uptake in tumor cells in vitro
24. Glut-1 and hexokinase expression: Relationship with 2-fluoro-2-deoxy-D-glucose uptake in A431 and T47D cells in culture
25. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
26. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
27. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
28. Hypoxia-inducible factor-1 alpha is regulated at the post-mRNA level
29. 2-dependent degradation domain via the ubiquitin-proteasome pathway
30. Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway
31. Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
32. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
33. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells
34. Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
35. Dual control of glut1 glucose transporter gene expression by hypoxia and by inhibition of oxidative phosphorylation
36. Induction of GLUT1 mRNA in response to inhibition of oxidative phosphorylation