Altering the purine specificity of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus by structure-based point mutations in the enzyme protein

Biochemistry

Volumn 37, Issue 47, 1998, Pages 16612-16619

  Munagala, Narsimha R ^a   Wang, Ching C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASPARTIC ACID; GLUTAMIC ACID; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; PURINE; TYROSINE; XANTHINE;

ARTICLE; ENZYME ACTIVE SITE; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; TRICHOMONAS FOETUS; TRICHOMONIASIS;

5'-GUANYLIC ACID; ADENINE PHOSPHORIBOSYLTRANSFERASE; AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; ASPARAGINE; ASPARTIC ACID; BINDING SITES; CATALYSIS; ENZYME ACTIVATION; GLUTAMIC ACID; GUANINE; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; ISOLEUCINE; LYSINE; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; POINT MUTATION; PURINES; RIBONUCLEOTIDES; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRITRICHOMONAS FOETUS; TYROSINE; XANTHINE;

EID: 0032564435     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9818974     Document Type: Article

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