Reaction mechanism of the HGXPRTase from Plasmodium falciparum: A hybrid potential quantum mechanical/molecular mechanical study

Journal of the American Chemical Society

Volumn 124, Issue 42, 2002, Pages 12432-12438

  Thomas, Aline ^a   Field, Martin J ^a  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID POTENTIAL;

CRYSTALLOGRAPHY; ENZYMES; FREE ENERGY; PROTEINS; QUANTUM THEORY; SUBSTITUTION REACTIONS;

REACTION KINETICS;

HYPOXANTHINE GUANINE XANTHINE PHOSPHORIBOSYLTRANSFERASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; NUCLEOTIDE; PROTEIN; PURINE; PYROPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CRYSTAL STRUCTURE; ENERGY; ENZYME MECHANISM; PARASITE; PLASMODIUM FALCIPARUM; PROTON TRANSPORT; QUANTUM MECHANICS; REACTION ANALYSIS; SYNTHESIS;

ANIMALS; COMPUTER SIMULATION; MODELS, MOLECULAR; PENTOSYLTRANSFERASES; PLASMODIUM FALCIPARUM; QUANTUM THEORY; THERMODYNAMICS;

EID: 0037164091     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0206846     Document Type: Article

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