G-protein diseases furnish a model for the turn-on switch

Nature

Volumn 394, Issue 6688, 1998, Pages 35-38

  Iiri, Taroh ^a,c   Farfel, Zvi ^b   Bourne, Henry R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE;

CHANNEL GATING; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME CONFORMATION; HUMAN; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

GTP-BINDING PROTEINS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; RECEPTORS, CELL SURFACE;

EID: 0032474767     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/27831     Document Type: Review

References (45)

1. Hamm, H. E. The many faces of G protein signaling. J. Biol. Chem. 273, 669-672 (1998).
2. Sprang, S. R. G protein mechanisms: Insights from structural analysis. Annu. Rev. Biochem. 66, 639-678 (1997).
3. Lambright, D. G. et al. The 2.0 Å crystal structure of a heterotrimetric G protein. Nature 379, 311-319 (1996).
4. Baldwin, J. M., Schertler, G. F. & Unger, V. M. An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors. J. Mol. Boil. 272, 144-164 (1997).
5. Hargrave, P. A., Hamm, H. E. & Hofmann, K. P. Interaction of rhodopsin with the G-protein, transducin. Bioessays 15, 43-50 (1993).
6. Fahmy, K., Siebert, F. & Sakmar, T. P. Photoactivated state of rhodopsin and how it can form. Biophys. Chem. 56, 171-181 (1995).
7. Strader, C. D., Fong, T. M., Graziano, M. P. & Tota, M. R. The family of G-protein-coupled receptors. FASEB J. 9, 745-754 (1995).
8. Bourne, H. R. How receptors talk to trimeric G proteins. Curr. Opin. Cell Biol. 134-142 (1997).
9. Bourne, H. R., Sanders, D. A. & McCormick, F. The GTPase superfamily. A conserved switch for diverse cell functions. Nature 348, 125-132 (1990).
10. Bourne, H. R., Sanders, D. A. & McCormick, F. The GTPase superfamily: Conserved structure and molecular mechanism. Nature 349, 117-127 (1991).
11. Bourne, H. R. The arginine finger strikes again. Nature 389, 673-674 (1997).
12. Bohm, A., Gaudet, R. & Sigler, P. B. Structural aspects of heterotrimeric G-protein signaling. Curr. Opin. Biotechnol. 8, 480-487 (1997).
13. Scheffzek, K. et al. The Ras - RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic ras mutants. Science 277, 333-338 (1997).
14. 4. Nature 372, 276-279 (1994).
15. iα1 and the mechanism of GTP hydrolysis. Science 265, 1405-1412 (1994).
16. iα1: stabilization of the transition state for GTP hydrolysis. Cell 89, 251-261 (1997).
17. Lambright, D. G., Noel, J. P., Hamm, H. E. & Sigler, P. B. The 1.8 Å crystal structure of transducin α-GDP: structural determinants for activation of a heterotrimeric G-protein α-subunit. Nature 369, 621-628 (1994).
18. Noel, J. P., Hamm, H. E. & Sigler, P. B. The 2.2 Å crystal structure of transducin α-GTPγS. Nature 366, 654-663 (1993).
19. a protein βγ dimer at 2.1 Å resolution. Nature 379, 369-374 (1996).
20. iα1 induced by GTP hydrolysis. Science 270, 954-960 (1995).
21. 1. Cell 83, 1047-1058 (1995).
22. sα. Science 278, 1943-1947 (1997).
23. Garcia, P. D., Onrust, R., Bell, S. M., Sakmar, T. P. & Bourne, H. R. Transducin-α C-terminal mutations prevent activation by rhodopsin: A new assay using recombinant proteins expressed in cultured cells. EMBO J. 14, 4460-4469 (1995).
24. Onrust, R. et al. Receptor and βγ binding sites in the α subunit of the retinal G protein transducin. Science 275, 381-384 (1997).
25. Hamm, H. E. et al. Site of G protein binding to rhodopsin mapped with synthetic peptides from the α subunit. Science 241, 832-835 (1988).
26. Kawashima, T., Berthet-Colominas, C., Wulff, M., Cusack, S. & Leberman, R. The structure of the Escherichia coli EF-Tu·EF-Ts complex at 2.5 Å resolution. Nature 379, 511-518 (1996).
27. Wang, Y., Jiang, Y., Meyering-Voss, M., Sprinzl, M. & Sigler, P. B. Crystal structure of the EF-Tu·EF-Ts complex from Thermus thermophilus. Nature Struct. Biol. 4, 950-956 (1997).
28. sα in patients with gain and loss of endocrine function. Nature 371, 164-168 (1994).
29. Feig, L. A. & Cooper, G. M. Relationship among guanine nucleotide exchange, GTP hydrolysis, and transofrming potential of mutated ras proteins. Mol. Cell. Biol. 8, 2472-2478 (1988).
30. sα mutant in a patient with Albright hereditrary osteodystrophy uncouples cell surface receptors from adenylyl cyclase. J. Biol. Chem. 269, 25387-25391 (1994).
31. West, R. E., Moss, J., Vaughan, M., Liu, T. & Liu, T. Y. Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine-347 is the ADP-ribose acceptor site. J. Biol. Chem. 260, 14428-14430 (1985).
32. Farrens, D. L., Altenbach, C., Yang, K., Hubbell, W. L. & Khorana,. G. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science 274, 768-770 (1996).
33. 1B receptor-G protein interactions. J. Biol. Chem. 272, 32071-32077 (1997).
34. Mazzoni, M. R. & Hamm, H. E. Interaction of transducin with light-activated rhodopsin protects It from proteolytic digestion by trypsin. J. Biol. Chem. 271, 30034-30040 (1996).
35. oα protein by deletion of the C terminus. J. Biol. Chem. 267, 9998-10002 (1992).
36. Ford, C. E. et al. Molecular basis for interactions of G protein βγ subunits with effectors. Science 280, 1271-1274 (1998).
37. Siffert, W. et al. Association of an allele of a human G-protein β3 subunit gene with hypertension. Nature Genet. 18, 45-48 (1998).
38. Iiri, T. & Bourne, H. R. G proteins propel surprise. Nature Genet. 18, 45-48 (1998).
39. Clapham, D. E. & Neer, E. J. G protein γβ subunits. Annu. Rev. Pharmacol. Toxicol. 37, 167-203 (1997).
40. q/11 and phospholipase C-β1. J. Biol. Chem. 267, 8081-8088 (1992).
41. 5α impairs receptor stimulation. J. Biol. Chem. 271, 19653-19655 (1996).
42. 5α mutant. Proc. Natl Acad. Sci. USA 94, 5656-3661 (1997).
43. βγ sequestration. Mol. Cell. Biol. 16, 6325-6337 (1996).
44. 2+ an the βγ-subunit on the interactions of guanine nucleotides with G proteins. J. Biol. Chem. 262, 762-766 (1987).
45. Sternweis, P. C. The active role of beta gamma in signal transduction. Curr. Opin. Cell Biol. 6, 198-203 (1994).