Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds

Blood

Volumn 97, Issue 1, 2001, Pages 297-304

  Cole, Alexander M ^a   Shi, Jishu ^a   Ceccarelli, Alejandro ^a   Kim, Yong Hwan ^a   Park, Albert ^a   Ganz, Tomas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHELICIDIN; CATHEPSIN G; ELASTASE; LEUKOCYTE ELASTASE; PROTEGRIN; SUPEROXIDE;

ANTIMICROBIAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; COLONY FORMING UNIT; DIFFUSION; ENZYME ACTIVITY; ESCHERICHIA COLI; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; NEUTROPHIL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SKIN INJURY; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STATISTICAL ANALYSIS; WESTERN BLOTTING;

EID: 0035163451     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.1.297     Document Type: Article

References (50)

1. Structure, function, and control of neutrophil proteinases
2. Granules of the human neutrophilic polymorphonuclear leukocyte
3. Putative role of neutrophil elastase in the pathogenesis of emphysema
4. The role of neutrophil elastase in chronic inflammation
5. The pathogenesis of emphysema: The elastase:antielastase hypothesis 30 years later
6. Therapeutic potential of neutrophilelastase inhibition in pulmonary disease
7. Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency
8. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis
9. Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase
10. Normal neutrophil function in cathepsin G-deficient mice
11. Lysis and killing of bacteria by lysosomal proteinases
12. Bactenecins, defense polypeptides of bovine neutrophils, are generated from precursor molecules stored in the large granules
13. Stimulus-induced maturation of probactenecins, precursors of neutrophil antimicrobial polypeptides
14. Proteolytic cleavage by neutrophil elastase converts inactive storage proforms to antibacterial bactenecins
15. Porcine polymorphonuclear leukocytes generate extracellular microbicidal activity by elastase-mediated activation of secreted proprotegrins
16. The role of protegrins and other elastase-activated polypeptides in the bactericidal properties of porcine inflammatory fluids
17. Amino acid sequence of PR-39: Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides
18. Protegrins: Leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins
19. A cDNA derived from pig bone marrow cells predicts a sequence identical to the intestinal antibacterial peptide PR-39
20. A novel cDNA sequence encoding a pig leukocyte antimicrobial peptide with cathelin-like pro-sequence
21. Identification of a new member of the protegrin family by cDNA cloning
22. Prophenin-1, an exceptionally proline-rich antimicrobial peptide from porcine leukocytes
23. Molecular cloning and identification of a novel porcine cathelin-like antibacterial peptide precursor
24. PMAP-37, a novel antibacterial peptide from pig myeloid cells: cDNA cloning, chemical synthesis and activity
25. Effects of pH and salinity on the antimicrobial properties of clavanins
26. Pseudomonas aeruginosa isolates from patients with cystic fibrosis: A class of serum-sensitive, nontypable strains deficient in lipopolysaccharide O side chains
27. Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds
28. Human neutrophil defensins and serpins form complexes and inactivate each other
29. Ultrasensitive assays for endogenous antimicrobial polypeptides
30. Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia
31. PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47 phox
32. The control of neutrophil chemotaxis by inhibitors of cathepsin G and chymotrypsin
33. Effects of a series of chloromethyl ketone protease inhibitors on superoxide release and the glutathione system in human polymorphonuclear leukocytes and alveolar macrophages
34. The polymorphonuclear leukocyte
35. Prophenin-1, an exceptionally proline-rich antimicrobial peptide from porcine leukocytes
36. Identification of a proline-arginine-rich antibacterial peptide from neutrophils that is analogous to PR-39, an antibacterial peptide from the small intestine
37. PMAP-37, a novel antibacterial peptide from pig myeloid cells: cDNA cloning, chemical synthesis and activity
38. Cell surface-bound elastase and cathepsin G on human neutrophils: A novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases
39. Effect of local application of the antimicrobial peptide IB-367 on the incidence and severity of oral mucositis in hamsters
40. FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis
41. Human CAP18: A novel antimicrobial lipopolysaccharide-binding protein
42. hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules
43. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes
44. Molecular cloning of a novel myeloid granule protein
45. Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse
46. Cathelicidins: A novel protein family with a common proregion and a variable C-terminal antimicrobial domain
47. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders
48. Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung
49. Structural characterization of BPI-modulating 15 kDa proteins from rabbit polymorphonuclear leukocytes: Identification of a novel family of leukocyte proteins
50. Posttranslational processing of defensins in immature human myeloid cells