Cystatin and cystatin-derived peptides have antibacterial activity against the pathogen Porphyromonas gingivalis

Biological Chemistry

Volumn 379, Issue 11, 1998, Pages 1371-1375

  Blankenvoorde, Michiel F J ^a   Van't Hof, Wim ^a   Walgreen Weterings, Els ^a   Martijn van Steenbergen, T J ^a   Brand, Henk S ^a   Veerman, Enno C I ^a   Nieuw Amerongen, Arie V ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Antibacterial; Cystatin; Cysteine proteinase; Peptide; Saliva

Indexed keywords

ANTIPAIN; CYSTATIN; CYSTATIN C; CYSTEINE PROTEINASE; LEUPEPTIN; PAPAIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CHICKEN; ENZYME ACTIVITY; GROWTH INHIBITION; NONHUMAN; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; CYSTATINS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PEPTIDES; PORPHYROMONAS GINGIVALIS; PROTEIN STRUCTURE, SECONDARY;

BACTERIA (MICROORGANISMS); GALLUS GALLUS; PORPHYROMONAS GINGIVALIS;

EID: 0031765280     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Agarwala, K.L., Kawabata, S.I., Hirata, M., Miyagi, M., Tsunasawa, S., and iwanaga, S. (1996). A cysteine protease inhibitor stored in the large granules of horseshoe crab hemocytes: purification, cDNA cloning and tissue localization. J. Biochem. 119, 85-94.
2. Aoki, H., Akaike, T., Abe, K., Kuroda, M., Arai, S., Okamura, R.I., Negi, A., and Maeda, H. (1995). Antiviral effects of oryzacystatin, a proteinase inhibitor in rice, against herpes simplex virus type 1 in vitro and In vivo. Antimicrob. Agents Chemother. 39, 846-849.
3. Beck-Sickinger, A.G., Dürr, H., and Jung, G. (1991). Semiautomated T-bag peptide synthesis using 9-fluorenyl-methoxycarbonyl strategy and benzotriazol-1-yl-tetramethyl-uronium tetrafluoroborate activation. Peptide Res. 4, 88-94.
4. Bell, J.E., Cunningham, E., Belt, C., Featherstone, J.D.B., and Bell, J. (1997). Examination of the potential structure of human salivary cystatins based on computer modelling. Arch. Oral. Biol. 42, 761-772.
5. Björck, L., Åkesson, P., Bohus, M., Trojnar, J., Abrahamson, M., Olafsson, I., and Grubb, A. (1989). Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor. Nature 337, 385-386.
6. Björck, L., Grubb, A., and Kjellen, L. (1990). Cystatin C, a proteinase inhibitor, blocks replication of herpes simplex virus. J. Virol. 64, 385-388.
7. Blankenvoorde, M.F.J., Henskens, Y.M.C., Van't Hof, W., Veerman, E.C.I., and Nieuw Amerongen, A.V. (1996). Inhibition of the growth and cysteine proteinase activity of Porphyromonas gingivalis by human salivary cystatin S and chicken cystatin. Biol. Chem. 377, 847-850.
8. Blankenvoorde, M.F.J., Henskens, Y.M.C., Van't Hof, W., Walgreen-Weterings, E., Veerman, E.C.I., and Nieuw Amerongen, A.V. (1997). Antibacterial activity against Porphyromonas gingivalis by cystatins. In: Hopsu-Havu, V.K., Järvinen, M., Kirschke, H., eds, Proteolysis in Cell Functions. (Amsterdam, The Netherlands: IOS Press), pp. 532-539.
9. Blankenvoorde, M.F.J., Brand, H.S., Henskens, Y.M.C., Veerman, E.C.I., and Nieuw Amerongen, A.V. (1998). The role of the proteinase inhibitor cystatin in the control of health and disease. Medical and industrial aspects. In: Michaud, D., ed. Recombinant Protease Inhibitors in Plants. (New York: Academic Press), In press.
10. Bode, W., Engh, R., Musil, D., Thiele, U., Huber, R., Karshikov, A., Brzin, J., Kos, J., and Turk, V. (1988). The 2.0 Å crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases. EMBO J. 7, 2593-2599.
11. Cimerman, N., Kosorok, M.D., Korant, B.D., Turk, B., and Turk, V. (1996). Characterization of cystatin C from bovine parotid glands - cysteine proteinase inhibition and antiviral properties. Biol. Chem. 377, 19-23.
12. Collins, A.R., and Grubb, A. (1991). Inhibitory effects of recpmbinant human cystatin C on human coronaviruses. Antimicrob, Agents Chemother. 35, 2444-2446.
13. Collins, A.R., and Grubb, A. (1998). Cystatin D, a natural salivary cysteine proteinase inhibitor, inhibits coronavirus replication at its physiological concentration. Oral. Microbiol. Immunol. 13, 59-61.
14. Cutler, C.W., Kalmar, J.R., and Genco, C.A. (1995). Pathogenic strategies of the oral anaerobe, Porphyromonas gingivalis, Trends Microbiol. 3, 45-50.
15. Eggert, F.-M., Chan, E.C.S., Klitorinos, A., and Flowerdew, G. (1995). Arginine is a common ligand for haemagglutination and protein binding by organisms inhabiting mucosal surfaces. Microb. Ecol. Health Dis. 8, 267-280.
16. Grenier, D. (1992). Effect of protease inhibitors on in vitro growth of Porphyromonas gingivalis. Microb. Ecol. Health Dis. 5, 133-138.
17. Hancock, R.E.W. (1997). Peptide antibiotics. Lancet 349, 418-422.
18. Heimerhorst, E.J., Van't Hof, W., Veerman, E.C.I., Simoons-Smit, I., and Nieuw Amerongen, A.V. (1997). Synthetic histatin ana- logues with broad-spectrum antimicrobial activity. Biochem. J. 326, 39-45.
19. Henskens, Y.M.C., Veerman, E.C.I., and Nieuw Amerongen, A.V. (1996). Cystatins in health and disease. Biol. Chem. 377, 7186.
20. Kondo, H., Ijiri, S., Abe, K., Maeda, H., and Arai, S. (1992). Inhibitory effect of oryzacystatins and a truncation mutant on the replication of poliovirus in infected Vero cells. FEBS Lett. 299, 48-50.
21. Korant, B.D., Brzin, J., and Turk, V. (1985). Cystatin, a protein inhibitor of cysteine proteinases alters viral protein cleavages in infected human cells. Biochem. Biophys. Res. Commun. 127, 1072-1076.
22. Korant, B.D., Towatari, T., Ivanoff, L., Petteway, S., Brzin, J., Lenarčič, B., and Turk, V. (1986). Viral therapy, prospects for protease inhibitors. J. Cell. Biochem. 32, 91-95.
23. Machleidt, W., Thiele, U., Laber, B., Assfalg-Machleidt, I., Esterl, A., Wiegand, G., Kos, J., Turk, V., and Bode, W. (1989). Mechanism of inhibition of papain by chicken egg white cystatin. FEBS Lett. 243, 234-238.
24. Meezaman, D., Charles, P., and Daskal, E. (1994). Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). J. Biol. Chem. 269, 12932-12939.
25. Naito, Y., Sasaki, M., Umemoto, T., Namikawa, I., Sakae, K., Ishihara, Y., Isomura, S., and Suzuki, I. (1995). Bactericidal effect of rat cystatin S on an oral bacterium Porphyromonas gingivalis. Comp. Biochem. Physiol. 120C, 71-75.
26. Potempa, J., Pike, R., and Travis, J. (1994). Host and Porphyromonas gingivalis proteinases in periodontitis: A biochemical model of Infection and tissue destruction. Perspect. Drug. Discov. Design. 2, 445-458.
27. Shah, H.N., and Gharbia, S.E. (1993a). Studies on the physiology and ecology of black-pigmented Gram-negative anaerobes which may be important in disease development. FEMS Immun. Med. Microb. 6, 165-172.
28. Shah, H.N., and Gharbia, S.E. (1993b). Batch culture and physiological properties. In: Shah, H.N., Mayrand, D., Genco, R.J., eds. Biology of the Species Porphyromonas gingivalis. (Boca Raton, FL, USA: CRC Press), pp. 85-103.
29. Stubbs, M.T., Laber, B., Bode, W., Huber, R., Jerala, R., Lenarčič, B., and Turk, V. (1990). The refined 2.4 Å X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction. EMBO J. 9, 1939-1947.
30. Takahashi, M., Tezuka, T., and Katunuma, N. (1994). Inhibition of growth and cysteine proteinase activity of Staphylococcus aureus V8 by phosphorylated cystatin α In skin cornified envelope. FEBS Lett. 355, 275-278.
31. Turk, B., Turk, V., and Turk, D. (1997). Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors. Biol. Chem. 378, 141-150.
32. Umemoto, T., Naito, Y., Li, M., Suzuki, I., and Namikawa, I. (1996). Growth inhibition of a human oral bacterium Porphyromonas gingivalis by rat cysteine proteinase inhibitor cystatin S. Lett. Appl. Microb. 23, 151-153.
33. Van't Hof, W., Driedijk, P.C., Van den Berg, M., Beck-Sickinger, A.G., Jung, G., and Aalberse, R.C. (1991). Epitope mapping of the Dermatophagoides pteronyssinus house dust mite major allergen Der p II using overlapping synthetic peptides. Mol. Immunol. 28, 1225-1232.
34. Weaver, T.R., Bergey, E.J., Levine, M.J., and Bobek, L.A. (1995). Effect of recombinant salivary cystatin on HSV-1 replication. J. Dent. Res. 74, 84. Abstr. 583.