Lessons for human diabetes from experimental mouse models

Current Diabetes Reports

Volumn 3, Issue 2, 2003, Pages 168-175

  Kulkarni, Rohit N ^a   Zisman, Ariel ^a  

^a JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADENOVIRUS VECTOR; ADENYLATE KINASE; ADIPONECTIN; AUTOANTIGEN; COMPLEMENTARY DNA; CYTOKINE; DNA VACCINE; GLUTAMATE DECARBOXYLASE; IMMUNOGLOBULIN G1; INSULIN; INSULIN DERIVATIVE; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 10; LEPTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYOSTATIN; PHOSPHATASE; PLASMID VECTOR; PROINSULIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; REGULATOR PROTEIN; ROSIGLITAZONE; SOMATOMEDIN; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TRIACYLGLYCEROL; TROGLITAZONE; TYROSINE; UNCOUPLING PROTEIN 2; UNINDEXED DRUG; HLA ANTIGEN CLASS 2;

ANIMAL MODEL; ANTIGEN EXPRESSION; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; DIABETES MELLITUS; DISEASE MODEL; DOSE RESPONSE; DRUG HALF LIFE; DRUG MEGADOSE; GENE DELIVERY SYSTEM; GENETIC ENGINEERING; GENETIC SUSCEPTIBILITY; GENOTYPE ENVIRONMENT INTERACTION; HEALTH CARE PLANNING; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; MEDICAL RESEARCH; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; STRUCTURE ANALYSIS; T LYMPHOCYTE; ANIMAL; GENE THERAPY; GENETICS; IMMUNOLOGY; METABOLISM; PANCREAS ISLET; PATHOPHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; CYTOKINES; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GENE THERAPY; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNE TOLERANCE; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, TRANSGENIC;

EID: 0037869113     PISSN: 15344827     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11892-003-0041-x     Document Type: Review

References (72)

1. Mathis D, Vence L, Benoist C: Beta-cell death during progression to diabetes. Nature 2002, 414:792-798.
2. Diabetes Public Health Resource. Atlanta, GA: US Department of Health and Human Resources, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health promotion; 2002.
3. Fagot-Campagna A, Pettitt DJ, Engelgau MM, et al.: Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr 2000, 136:664-672.
4. Saltiel AR, Kahn CR: Insulin signaling and the regulation of glucose and lipid metabolism. Nature 2001, 414:799-806.
5. Elbein SC: Genetics of type 2 diabetes: an overview for the millennium. Diabetes Technol Ther 2000, 2:391-400.
6. Hribal ML, Oriente F, Accili D: Mouse models of insulin resistance. Am J Endocrinol Metab 2002, 282:E977-E981.
7. Adorini L, Gregori S, Harrison LC: Understanding autoimmune diabetes: insights from mouse models. Trends Mol Med 2002, 8:31-38.
8. French MB, Allison J, Cram DS, et al.: Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes 1997, 46:34-39.
9. Pugliese A, Zeller M, Fernandez A Jr, et al.: The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 1997, 15:293-297.
10. Chentoufi AA, Polychronakos C: Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 2002, 51:1383-1390.
11. Duvillie B, Cordonnier N, Deltour L, et al.: Phenotypic alterations in insulin-deficient mutant mice. Proc Natl Acad Sci U S A 1997, 94:5137-5140.
12. Moriyama H, Paronen J, Liu E, et al.: Testing the hypothesis that the insulin 1 gene is essential for diabetogenesis and knockout of insulin 2 gene accelerates diabetes in NOD mice [abstract]. Diabetes Metab Res Rev 2002, 18(suppl 4):S26.
13. Ramsey C, Bukrinsky A, Peltonen L: Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targeting. Hum Mol Genet 2002, 11:397-409.
14. Anderson MS, Venanzi ES, Klein L, et al.: Projection of an immunological self shadow within the thymus by the aire protein. Science 2002, 298:1395-1401.
15. Pugliese A, Diez J: Lymphoid organs contain diverse cells expressing self-molecules. Nat Immunol 2002, 3:335-336.
16. Pugliese A, Brown D, Garza D, et al.: Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs. J Clin Invest 2001, 107:555-564.
17. Raju R, Munn SR, David CS: T cell recognition of human preproinsulin peptides depends on the polymorphism at HLA DQ locus: a study using HLA DQ8 and DQ6 transgenic mice. Hum Immunol 1997, 58:21-29.
18. Wen L, Wong FS, Burkly L, et al.: Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice. J Clin Invest 1998, 102:947-957.
19. Wen L, Wong FS, Tang J, et al.: In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes. J Exp Med 2000, 191:97-104.
20. Wen L, Chen NY, Tang J, et al.: The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model. J Clin Invest 2001, 107:871-880.
21. Corper AL, Stratmann T, Apostolopoulos V, et al.: A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes. Science 2000, 288:505-511.
22. Wen L, Wong FS, Sherwin R, Mora C: Human DQ8 can substitute for murine I-Ag7 in the selection of diabetogenic T cells restricted to I-Ag7. J Immunol 2002, 168:3635-3640.
23. Abraham RS, Wen L, Marietta EV, David CS: Type 1 diabetes-predisposing MHC alleles influence the selection of glutamic acid decarboxylase (GAD) 65-specific T cells in a transgenic model. J Immunol 2001, 166:1370-1379.
24. Kudva YC, Rajagopalan G, Raju R, et al.: Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II. Hum Immunol 2002, 63:987-999.
25. Kudva YC, Deng YJ, Govindarajan R, et al.: HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2. Hum Immunol 2001, 62:1099-1105.
26. Liu E, Moriyama H, Abiru N, et al.: Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23. J Clin Invest 2002, 110:1021-1027.
27. Balasa B, Boehm BO, Fortnagel A, et al.: Vaccination with glutamic acid decarboxylase plasmid DNA protects mice from spontaneous autoimmune diabetes and B7/CD28 costimulation circumvents that protection. Clin Immunol 2001, 99:241-252.
28. Karges W, Pechhold K, Al Dahouk S, et al.: Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice. Diabetes 2002, 51:3237-3244.
29. Bot A, Smith D, But S, et al.: Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice. J Immunol 2001, 167:2950-2955.
30. Effects of insulin in relatives of patients with type 1 diabetes mellitus [no authors listed]. N Engl J Med 2002, 346:1685-1691.
31. Nitta Y, Tashiro F, Tokui M, et al.: Systemic delivery of interleukin 10 by intramuscular injection of expression plasmid DNA prevents autoimmune diabetes in nonobese diabetic mice. Hum Gene Ther 1998, 9:1701-1707.
32. Cameron MJ, Strathdee CA, Holmes KD, et al.: Biolistic-mediated interleukin 4 gene transfer prevents the onset of type 1 diabetes. Hum Gene Ther 2000, 11:1647-1656.
33. Moritani M, Yoshimoto K, Tashiro F, et al.: Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice. Int Immunol 1994, 6:1927-1936.
34. Goudy K, Song S, Wasserfall C, et al.: Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice. Proc Natl Acad Sci U S A 2001, 98:13913-13918.
35. Saeki K, Zhu M, Kubosaki A, et al.: Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion. Diabetes 2002, 51:1842-1850.
36. Matarese G, Sanna V, Lechler RI, et al.: Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes 2002, 51:1356-1361.
37. Beales PE, Pozzilli P: Thiazolidinediones for the prevention of diabetes in the non-obese diabetic (NOD) mouse: implications for human type 1 diabetes. Diabetes Metab Res Rev 2002, 18:114-117.
38. Warram JH, Martin BC, Krolewski AS, et al.: Slow glucose removal rate and hyperinsulinemia are predictors of the risk of type 2 diabetes in offspring of diabetic parents. Ann Intern Med 1990, 113:909-915.
39. Almind K, Doria A, Kahn CR: Putting the genes for type 2 diabetes on the map. Nat Med 2001, 7:277-279.
40. Sethi JK, Hotamisligil GS: The role of TNF alpha in adipocyte metabolism. Semin Cell Dev Biol 1999, 10:19-29.
41. Aguirre V, Uchida T, Yenush L, et al.: The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 2000, 275:9047-9054.
42. Hirosumi J, Tuncman G, Chang L, et al.: A central role for JNK in obesity and insulin resistance. Nature 2002, 420:333-336.
43. Waeber G, Delplanque J, Bonny C, et al.: The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nat Genet 2000, 24:291-295.
44. Araki E, Lipes MA, Patti ME, et al.: Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene. Nature 1994, 372:186-190.
45. Kulkarni RN, Winnay JN, Daniels M, et al.: Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest 1999, 104:R69-R75.
46. Almind K, Bjorbaek C, Vestergaard H, et al.: Amino acid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. Lancet 1993, 342:828-832.
47. Liu SC, Wang Q, Lienhard GE, Keller SR: Insulin receptor substrate 3 is not essential for growth or glucose homeostasis. J Biol Chem 1999, 274:18093-18099.
48. Laustsen PG, Michael MD, Crute BE, et al.: Lipoatrophic diabetes in Irs1 (-/-)/Irs3 (-/-) double knockout mice. Genes Dev 2002, 16:3213-3222.
49. Gavrilova O, Marcus-Samuels B, Leon LR, et al.: Leptin and diabetes in lipoatrophic mice. Nature 2000, 403:850-851.
50. Bjornholm M, He AR, Attersand A, et al.: Absence of functional insulin receptor substrate-3 ( IRS-3) gene in humans. Diabetologia 2002, 45:1697-1702.
51. Yamauchi T, Kamon J, Waki H, et al.: The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001, 7:941-946.
52. Yamauchi T, Kamon J, Waki H, et al.: Globular adiponectin protected ob/ob mice from diabetes and apoE deficient mice from atherosclerosis. J Biol Chem 2003, 278:2461-2468.
53. Kubota N, Terauchi Y, Yamauchi T, et al.: Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 2002, 277:25863-25866.
54. Yamauchi T, Kamon J, Minokoshi Y, et al.: Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002, 8:1288-1295.
55. Ma K, Cabrero A, Saha PK, et al.: Increased beta-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem 2002, 277:34658-34661.
56. Zisman A, Peroni OD, Abel D, et al.: Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med 2000, 6:924-928.
57. Kim JK, Zisman A, Fillmore JJ, et al.: Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. J Clin Invest 2001, 108:153-160.
58. McPherron AC, Lee SJ: Suppression of body fat accumulation in myostatin-deficient mice. J Clin Invest 2002, 109:595-601.
59. Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, et al.: Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci U S A 1998, 95:14938-14943.
60. Shih DQ, Stoffel M: Dissecting the transcriptional network of pancreatic islets during development and differentiation. Proc Natl Acad Sci U S A 2001, 98:14189-14191.
61. Shih DQ, Heimesaat M, Kuwajima S, et al.: Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1a, and Hnf-3b. Proc Natl Acad Sci U S A 2002, 99:3818-3823.
62. Thomas MK, Devon ON, Lee JH, et al.: Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1. J Clin Invest 2001, 108:319-329.
63. Bernassola F, Federici M, Corazzari M, et al.: Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient. FASEB J 2002, 11:1371-1378.
64. Kulkarni RN: Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function. Biochem Soc Trans 2002, 30:317-322.
65. Hill DJ, Duvillie B: Pancreatic development and adult diabetes. Pediatr Res 2000, 48:269-274.
66. Kulkarni RN, Holzenberger M, Shih DQ, et al.: Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet 2002, 31:111-115.
67. Xuan S, Kitamura T, Nakae J, et al.: Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest 2002, 110:1011-1019.
68. Vaessen N, Heutink P, Janssen JA, et al.: A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction. Diabetes 2001, 50:637-642.
69. Boss O, Hagen T, Lowell BB: Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism. Diabetes 2000, 49:143-156.
70. Zhang CY, Baffy G, Perret P, et al.: Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 2002, 105:745-755.
71. Esterbauer H, Schneitler C, Oberkofler H, et al.: A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Genet 2001, 28:178-183.
72. Watanabe H, Katakami C, Miyata S, Negi A: Corneal disorders in KKAy mouse: a type 2 diabetes model. Jpn J Ophthalmol 2002, 46:130-139.